Browse our anti-Leptin Receptor (LEPR) Antibodies

Human Leptin Receptor (LEPR) interaction partners

1. Results show that LEPR rs1137101 allele G was associated with reduced BMI and waist-to-hip ratio; however, it showed a marginal contribution to lower risk of obesity and MetS (show ETV3 Antibodies) in obese patients. These finding suggest that LEPR genetic variant may be useful biomarker of cardiometabolic risk in obese patients.

2. the multivariate analysis showed that only gene polymorphism (GG versus GA +AA) and tumor stage significantly affect survival. LEPR gene variants rs1137101 might be a candidate risk factor for renal cell carcinoma (show MOK Antibodies) in Egypt.

3. find for the first time that there is a significant association between leptin receptor rs1137101 polymorphism and susceptibility to NSTEMI. There is also statistically meaningful association between decrease in serum selenium and increase in serum copper levels with susceptibility to NSTEMI

4. LEPR Lys109Arg (rs1137100) was associated with polycystic ovary syndrome susceptibility and genotype AA was deduced to be a protective factor for polycystic ovary syndrome

5. leptin (show LEP Antibodies), leptin receptor and apelin receptor (show APLNR Antibodies) genes are associated with susceptibility to coronary artery disease and hypertension

6. This study provides evidence that polymorphisms in the LEP (show LEP Antibodies) and LEPR genes are associated with the magnitude of the effects of regular physical activity on glucose and LDL-C levels, respectively. In addition, we found the association of the G allele of the LEPR polymorphism with body mass and BMI

7. No differences in the distribution of prevalence of alleles and LEPR gene Q223R (rs1137101) genotypes in the groups of female patients with the knee joint osteoarthritis of different radiographic stages have been revealed.

8. Study shows that plasma soluble leptin receptor levels are independently associated with pancreatic beta-cell function, but not with insulin (show INS Antibodies) resistance, in patients with type 2 diabetes.

9. The results suggest that LEPR rs1327118 may be associated with elevated blood pressure and HDL (show HSD11B1 Antibodies)-C levels in women with type 2 diabetes mellitus (T2DM), and rs3806318 may be associated with T2DM and elevated blood pressure in men with T2DM.

10. Study demonstrated that in all tested human normal prostate and prostate cancer cell lines (LNCaP, DU145, PC3 (show PCSK1 Antibodies), PrEC, PrSMC and PrSC) transcription variants 4, 5 and 6 of the leptin receptor were not expressed. Leptin receptor transcription variants 1, 2 and 3 showed differential expression, all of them present in the PC3 (show PCSK1 Antibodies), PrEC and PrSC cell lines.

Mouse (Murine) Leptin Receptor (LEPR) interaction partners

1. Expression of IGF-1 (show IGF1 Antibodies) and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model.

2. Data (including data from studies using mutant, transgenic, and knockout mice) suggest that gene targets of leptin/leptin (show LEP Antibodies)-receptor (Lep (show LEP Antibodies)/Lepr) signaling in hypothalamic neurons regulate energy metabolism; Lep (show LEP Antibodies)/Lepr signaling appears to up-regulate expression of Atf3 (activating transcription factor-3 (show ATF3 Antibodies)) in hypothalamic neurons.

3. Study shows that compared to the other mouse lines, db/db mice with dysfunctional leptin (show LEP Antibodies) receptors had a significantly longer tail flick latency after saline and buprenorphine. The results provide novel support for the interpretation that acute thermal nociception is associated with altered leptin (show LEP Antibodies) signaling.

4. The leptin-receptor mice is not a proper model for secondary osteoporosis associated with type 2 diabetes mellitus.

5. Data show that leptin receptor deficient (LeprNULL) mice exhibited increased body weight and food intake.

6. This study reports about bone quality and bone turnover mechanisms in leptin receptor-deficient animals.

7. Neurotensin (show NTS Antibodies)-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors.

8. Suggest that intact endothelial leptin (show LEP Antibodies) signaling limits neointima formation and that obesity represents a state of endothelial leptin (show LEP Antibodies) resistance.

9. Identify Lepr(+) stromal lineage cells as the origin of myofibroblasts in primary myelofibrosis and suggest that targeting PDGFRA (show PDGFRA Antibodies) signalling could be an effective way to treat bone marrow fibrosis.

10. Leptin (show LEP Antibodies) expression is regulated by DNA methylation (show HELLS Antibodies) in adipocytes.

Pig (Porcine) Leptin Receptor (LEPR) interaction partners

1. polymorphisms in the 5' regulatory region of LEPR gene are associated with meat quality traits in Berkshire pigs

2. study has allowed a transcriptional characterization of LEP (show LEP Antibodies) and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function

3. LEPR showed a lower variability than LEP (show LEP Antibodies) in the different analysed populations, especially in the Iberian breed that showed no variability

4. Superactive human leptin (show LEP Antibodies) antagonist reverses leptin (show LEP Antibodies)-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin (show LEP Antibodies) receptors.

5. The presence of leptin (show LEP Antibodies) and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

6. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

7. Data showing changes in expression patterns of LEP (show LEP Antibodies)/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP (show LEP Antibodies)/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.

8. Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin (show LEP Antibodies)

9. Leptin (show LEP Antibodies) and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin (show LEP Antibodies) mRNA expression as well as E and P on leptin (show LEP Antibodies) secretion by those cells obtained in early pregnancy.

10. These data suggest that leptin (show LEP Antibodies) might have a direct effect on porcine follicles and plays an important role in the follicular development.

Cow (Bovine) Leptin Receptor (LEPR) interaction partners

1. Here, the association between DGAT1 (show DGAT1 Antibodies) K232A, SCD1 (show SCD Antibodies) A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1 (show DGAT1 Antibodies), SCD1 (show SCD Antibodies), and LEPR polymorphisms were GC/GC (show GC Antibodies), C, and C, respectively.

2. I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression

3. The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.

4. SNP LEP (show LEP Antibodies) significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only

5. The use of leptin (show LEP Antibodies), leptin receptor, and DGAT1 (show DGAT1 Antibodies) polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.

6. The leptin (show LEP Antibodies) and receptor gene markers would be useful for marker-assisted selection.

7. The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.

8. The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.

9. the possible involvement of locally produced leptin (show LEP Antibodies)/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.

10. findings indicate that acetate and butyrate enhance leptin (show LEP Antibodies) expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries

Rhesus Monkey Leptin Receptor (LEPR) interaction partners

1. A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).