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LEP 3'UTR A/C and LEPR K109R polymorphisms were associated with Leptin levels and obesity in Tunisian volunteers.
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The risk allele (G) of the rs1137100 variant was associated with excess weight in individuals with fat consumption below the median. The risk allele (G) of variant rs1177681 was also associated with excess weight in subjects with a daily frequency of refined cereal consumption above the median.
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we report several associations between maternal and fetal LEPR common SNPs and gestational glycemic traits. These associations were nominally significant before correction for multiple comparisons.
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reveal that breast cancer stem cell (BCSC) in triple-negative breast cancer depend on the transcription regulator HN1L for the sustained activation of the LEPR-STAT3 pathway, which makes it a potentially important target for both prognosis and BCSC therapy.
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LEPR rs1137101 and PPARG-2 rs1801282 had weak and medium negative effects on zBMI, respectively, and may slightly protect against childhood obesity.
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Study demonstrates that the human LR undergoes regulated intramembrane proteolysis and that the released LR intracellular domain translocates to the mitochondria where it inhibits Parkin-dependent mitophagy.
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acetaminophen was associated with asthma similarly extent among males and females carrying two common alleles of LEPR polymorphisms.Among those carrying at least one copy of the minor allele of LEPR polymorphisms, the magnitude of association between acetaminophen use and asthma was pronounced among males but not among females
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this study shows that leptin receptor q223r polymorphism influences neutrophil mobilization after Clostridium difficile infection
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Here, we present two crystal structures of the human JAK2 FERM and SH2 domains bound to Leptin receptor (LEPR) and Erythropoietin receptor (EPOR), which identify a novel dimeric conformation for JAK2.
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serum levels increased in systemic lupus erythematosus patients with metabolic syndrome and correlated with carotid intima media thickness values
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Results show that LEPR rs1137101 allele G was associated with reduced BMI and waist-to-hip ratio; however, it showed a marginal contribution to lower risk of obesity and MetS in obese patients. These finding suggest that LEPR genetic variant may be useful biomarker of cardiometabolic risk in obese patients.
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the multivariate analysis showed that only gene polymorphism (GG versus GA +AA) and tumor stage significantly affect survival. LEPR gene variants rs1137101 might be a candidate risk factor for renal cell carcinoma in Egypt.
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find for the first time that there is a significant association between leptin receptor rs1137101 polymorphism and susceptibility to NSTEMI. There is also statistically meaningful association between decrease in serum selenium and increase in serum copper levels with susceptibility to NSTEMI
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LEPR Lys109Arg (rs1137100) was associated with polycystic ovary syndrome susceptibility and genotype AA was deduced to be a protective factor for polycystic ovary syndrome
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leptin, leptin receptor and apelin receptor genes are associated with susceptibility to coronary artery disease and hypertension
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This study provides evidence that polymorphisms in the LEP and LEPR genes are associated with the magnitude of the effects of regular physical activity on glucose and LDL-C levels, respectively. In addition, we found the association of the G allele of the LEPR polymorphism with body mass and BMI
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No differences in the distribution of prevalence of alleles and LEPR gene Q223R (rs1137101) genotypes in the groups of female patients with the knee joint osteoarthritis of different radiographic stages have been revealed.
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Study shows that plasma soluble leptin receptor levels are independently associated with pancreatic beta-cell function, but not with insulin resistance, in patients with type 2 diabetes.
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The results suggest that LEPR rs1327118 may be associated with elevated blood pressure and HDL-C levels in women with type 2 diabetes mellitus (T2DM), and rs3806318 may be associated with T2DM and elevated blood pressure in men with T2DM.
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Study demonstrated that in all tested human normal prostate and prostate cancer cell lines (LNCaP, DU145, PC3, PrEC, PrSMC and PrSC) transcription variants 4, 5 and 6 of the leptin receptor were not expressed. Leptin receptor transcription variants 1, 2 and 3 showed differential expression, all of them present in the PC3, PrEC and PrSC cell lines.