Browse our anti-Leptin Receptor (LEPR) Antibodies

Human Leptin Receptor (LEPR) interaction partners

1. Leptin and SLeptinR[ serum Leptin receptor] are independently and inversely associated with GDM [of gestational diabetes mellitus]. Lower levels of these peptides may play an important role in the pathophysiology of GDM and pre-diabetic state in post-puerperium.

2. Loss-of-function mutation in the LEPR segregated with early-onset severe obesity and hyperphagia in an extended consanguineous family.

3. A significant association between LEPR single nucleoitde polymorphism rs8179183 and overweight/obesity in Chinese Han adolescents.

4. LEP 3'UTR A/C and LEPR K109R polymorphisms were associated with Leptin levels and obesity in Tunisian volunteers.

5. The risk allele (G) of the rs1137100 variant was associated with excess weight in individuals with fat consumption below the median. The risk allele (G) of variant rs1177681 was also associated with excess weight in subjects with a daily frequency of refined cereal consumption above the median.

6. we report several associations between maternal and fetal LEPR common SNPs and gestational glycemic traits. These associations were nominally significant before correction for multiple comparisons.

7. reveal that breast cancer stem cell (BCSC) in triple-negative breast cancer depend on the transcription regulator HN1L for the sustained activation of the LEPR-STAT3 pathway, which makes it a potentially important target for both prognosis and BCSC therapy.

8. LEPR rs1137101 and PPARG-2 rs1801282 had weak and medium negative effects on zBMI, respectively, and may slightly protect against childhood obesity.

9. Study demonstrates that the human LR undergoes regulated intramembrane proteolysis and that the released LR intracellular domain translocates to the mitochondria where it inhibits Parkin-dependent mitophagy.

10. acetaminophen was associated with asthma similarly extent among males and females carrying two common alleles of LEPR polymorphisms.Among those carrying at least one copy of the minor allele of LEPR polymorphisms, the magnitude of association between acetaminophen use and asthma was pronounced among males but not among females

11. this study shows that leptin receptor q223r polymorphism influences neutrophil mobilization after Clostridium difficile infection

12. Here, we present two crystal structures of the human JAK2 FERM and SH2 domains bound to Leptin receptor (LEPR) and Erythropoietin receptor (EPOR), which identify a novel dimeric conformation for JAK2.

13. serum levels increased in systemic lupus erythematosus patients with metabolic syndrome and correlated with carotid intima media thickness values

14. Results show that LEPR rs1137101 allele G was associated with reduced BMI and waist-to-hip ratio; however, it showed a marginal contribution to lower risk of obesity and MetS in obese patients. These finding suggest that LEPR genetic variant may be useful biomarker of cardiometabolic risk in obese patients.

15. the multivariate analysis showed that only gene polymorphism (GG versus GA +AA) and tumor stage significantly affect survival. LEPR gene variants rs1137101 might be a candidate risk factor for renal cell carcinoma in Egypt.

16. find for the first time that there is a significant association between leptin receptor rs1137101 polymorphism and susceptibility to NSTEMI. There is also statistically meaningful association between decrease in serum selenium and increase in serum copper levels with susceptibility to NSTEMI

17. LEPR Lys109Arg (rs1137100) was associated with polycystic ovary syndrome susceptibility and genotype AA was deduced to be a protective factor for polycystic ovary syndrome

18. leptin, leptin receptor and apelin receptor genes are associated with susceptibility to coronary artery disease and hypertension

19. This study provides evidence that polymorphisms in the LEP and LEPR genes are associated with the magnitude of the effects of regular physical activity on glucose and LDL-C levels, respectively. In addition, we found the association of the G allele of the LEPR polymorphism with body mass and BMI

20. No differences in the distribution of prevalence of alleles and LEPR gene Q223R (rs1137101) genotypes in the groups of female patients with the knee joint osteoarthritis of different radiographic stages have been revealed.

Mouse (Murine) Leptin Receptor (LEPR) interaction partners

1. These lines of evidence suggest that downregulation of Ob-R and kisspeptin/GPR54 in the murine hypothalamus may contribute to male hypogonadism caused by high-fat diet-induced obesity.

2. Knockin of Lepr in beta cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia.

3. Abnormal sex hormone levels of Y123F mice were due to not only decreased gonadotropin levels in the central nervous system, but also ovarian hormone synthase abnormalities in the peripheral gonads.

4. Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model.

5. Data (including data from studies using mutant, transgenic, and knockout mice) suggest that gene targets of leptin/leptin-receptor (Lep/Lepr) signaling in hypothalamic neurons regulate energy metabolism; Lep/Lepr signaling appears to up-regulate expression of Atf3 (activating transcription factor-3) in hypothalamic neurons.

6. Study shows that compared to the other mouse lines, db/db mice with dysfunctional leptin receptors had a significantly longer tail flick latency after saline and buprenorphine. The results provide novel support for the interpretation that acute thermal nociception is associated with altered leptin signaling.

7. The leptin-receptor mice is not a proper model for secondary osteoporosis associated with type 2 diabetes mellitus.

8. Data show that leptin receptor deficient (LeprNULL) mice exhibited increased body weight and food intake.

9. This study reports about bone quality and bone turnover mechanisms in leptin receptor-deficient animals.

10. Neurotensin-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors.

11. Suggest that intact endothelial leptin signaling limits neointima formation and that obesity represents a state of endothelial leptin resistance.

12. Identify Lepr(+) stromal lineage cells as the origin of myofibroblasts in primary myelofibrosis and suggest that targeting PDGFRA signalling could be an effective way to treat bone marrow fibrosis.

13. Leptin expression is regulated by DNA methylation in adipocytes.

14. Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1).

15. LepRb preoptic area neurons are stimulatory glutamatergic neurons, contrary to prevalent models

16. Leptin receptors on agouti-related peptide neurons modulate the onset of puberty and adult fertility.

17. Leptin/LepR signaling regulates adipogenesis and osteogenesis by mesenchymal stromal cells in the bone marrow in response to diet and adiposity.

18. These data show that leptin directly impairs vascular relaxation via a vascular skeletal muscle-LepR-mediated mechanism, suggesting a potential pathogenic role for leptin to increase cardiovascular risk during obesity.

19. These mice showed an increase in FSH levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice.

20. we report that estradiol has minimal direct actions on LepRb cells in the mediodasal hypothalamus and that its anorexigenic effects can occur entirely independently of LepRb-STAT3 signaling in female mice.

Pig (Porcine) Leptin Receptor (LEPR) interaction partners

1. polymorphisms in the 5' regulatory region of LEPR gene are associated with meat quality traits in Berkshire pigs

2. study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function

3. LEPR showed a lower variability than LEP in the different analysed populations, especially in the Iberian breed that showed no variability

4. Superactive human leptin antagonist reverses leptin-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin receptors.

5. The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

6. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

7. Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.

8. Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin

9. Leptin and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.

10. These data suggest that leptin might have a direct effect on porcine follicles and plays an important role in the follicular development.

11. Locally produced leptin plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor gene expression varies in the ovaries of pregnant and cyclic pigs.

12. results suggest the T alleles of both LEP g.1387C>T and LEPR c.1987C>T, which are fixed in the Iberian pigs, would lead to an increase in growth, fatness and saturated fatty acid content in fat, which could be explained by an increased feed intake

13. These results of the current study indicated that the c.2002C>T SNP of LEPR has a strong effect on BF, fat area ratios and LEPC.

14. The differences in luteal function in leptin resistance genotype and lean genotype swine due to leptin receptor polymorphism are reported.

15. Conceptus viability and growth were found to be related to the placental expression of the vascular endothelial growth factor A (VEGFA) and leptin (LEP) genes.

16. A polymorphism in LEPR decreased the yield of premium cuts of meat.

17. 87C>T polymorphism is associated with body weight and back fat thickness

18. The objective of this study was to investigate the effect of FABP3 and LEPR genetic variations as well as their mRNA expression on the intramuscular fat content trait in a three-generation of Korean native pig and Yorkshire crossed animals.

19. These results indicate that both leptin and OB-Rb are synthesized in the porcine hypothalamus and participate in control of reproduction during the oestrous cycle and early pregnancy.

20. Data show that treatment with GH or IGF-I reduced leptin receptor expression, and increased Phosphorylation of ERK1/2 in response to acute leptin.

Cow (Bovine) Leptin Receptor (LEPR) interaction partners

1. Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1, SCD1, and LEPR polymorphisms were GC/GC, C, and C, respectively.

2. I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression

3. The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.

4. SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only

5. The use of leptin, leptin receptor, and DGAT1 polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.

6. The leptin and receptor gene markers would be useful for marker-assisted selection.

7. The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.

8. The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.

9. the possible involvement of locally produced leptin/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.

10. findings indicate that acetate and butyrate enhance leptin expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries

11. leptin receptor is expressed in the bovine corpus luteum and is modulated by leptin.

12. The results demonstrated that each Ob-R isoform mRNA was differentially expressed in various tissues of cattle, which may be involved in the difference of peripheral actions for leptin.

13. Lep may regulate gonadotroph function through autocrine/paracrine pathway in the bovine adenohypophysis.

14. Polymorphism in LEPR did not affect significantly any of the traits studied here: daily milk production, feed intake, and feed conversion, and weekly measures of live weight, BCS, or body energy traits

15. the LEPR gene is a strong candidate gene that affects growth traits in cattle.

Rhesus Monkey Leptin Receptor (LEPR) interaction partners

1. A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).