Browse our anti-Leptin Receptor (LEPR) Antibodies

Human Leptin Receptor (LEPR) interaction partners

1. Skeletal muscle leptin (show LEP Antibodies) receptors are up-regulated in response to severe energy deficit.

2. The leptin receptor polymorphism seems to affect neuroendocrine regulation of energy balance among adolescents with obesity.

3. Elevated serum leptin (show LEP Antibodies) level could be a predictor for arterial stiffness in hypertension patients.

4. LEP (show LEP Antibodies) and LEPR single-nucleotide polymorphisms are not associated with genetic susceptibility to systemic lupus erythematosus.

5. Studied adiponectin (ADIPOQ), leptin (LEP (show LEP Antibodies)), leptin receptor (LEPR), and resistin (RETN (show RETN Antibodies)) single nucleotide polymorphisms and their association in obesity. Results showed that ADIPOQ 4522CLEP (show LEP Antibodies) 2548GRETN (show RETN Antibodies) 420C

6. Study found an association between LEPR expression and malignant behavior of upper tract urothelial carcinoma. High LEPR expression is independently associated with poor recurrence-free and progression-free survival.

7. Mendelian randomization study estimating the causal effect of leptin (show LEP Antibodies) on Alzheimer disease (AD) did not find an effect of genetically predicted circulating leptin (show LEP Antibodies) and sOB-R levels on AD. As such, this study suggests that leptin (show LEP Antibodies) is unlikely to be a major contributor to AD, although the wide confidence intervals preclude a definitive assessment.

8. Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin (show INS Antibodies) Resistance in Spanish Female Obese Children.

9. Leptin (show LEP Antibodies), and leptin receptor polymorphisms and breast cancer risk in a Chinese cohort of women.

10. We demonstrate that leptin (show LEP Antibodies) stimulates the phosphorylation of STAT3 (show STAT3 Antibodies) in LEPRb-transfected non-cancer stem cells (CSCs) compared with non-transfected non-CSCs. The increased expression of LEPRb and STAT3 (show STAT3 Antibodies) activation recapitulated the phosphorylation status of STAT3 (show STAT3 Antibodies) in CSCs. Our data demonstrate that LEPRb-induced STAT3 (show STAT3 Antibodies) activation is essential for the induction and maintenance of triple-negative breast cancer CSCs.

Mouse (Murine) Leptin Receptor (LEPR) interaction partners

1. Data (including data from studies using mutant, transgenic, and knockout mice) suggest that gene targets of leptin/leptin (show LEP Antibodies)-receptor (Lep (show LEP Antibodies)/Lepr) signaling in hypothalamic neurons regulate energy metabolism; Lep (show LEP Antibodies)/Lepr signaling appears to up-regulate expression of Atf3 (activating transcription factor-3 (show ATF3 Antibodies)) in hypothalamic neurons.

2. Study shows that compared to the other mouse lines, db/db mice with dysfunctional leptin (show LEP Antibodies) receptors had a significantly longer tail flick latency after saline and buprenorphine. The results provide novel support for the interpretation that acute thermal nociception is associated with altered leptin (show LEP Antibodies) signaling.

3. The leptin-receptor mice is not a proper model for secondary osteoporosis associated with type 2 diabetes mellitus.

4. Data show that leptin receptor deficient (LeprNULL) mice exhibited increased body weight and food intake.

5. This study reports about bone quality and bone turnover mechanisms in leptin receptor-deficient animals.

6. Neurotensin (show NTS Antibodies)-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors.

7. Suggest that intact endothelial leptin (show LEP Antibodies) signaling limits neointima formation and that obesity represents a state of endothelial leptin (show LEP Antibodies) resistance.

8. Identify Lepr(+) stromal lineage cells as the origin of myofibroblasts in primary myelofibrosis and suggest that targeting PDGFRA (show PDGFRA Antibodies) signalling could be an effective way to treat bone marrow fibrosis.

9. Leptin (show LEP Antibodies) expression is regulated by DNA methylation (show HELLS Antibodies) in adipocytes.

10. Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1 (show PRDM1 Antibodies)).

Pig (Porcine) Leptin Receptor (LEPR) interaction partners

1. polymorphisms in the 5' regulatory region of LEPR gene are associated with meat quality traits in Berkshire pigs

2. study has allowed a transcriptional characterization of LEP (show LEP Antibodies) and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function

3. LEPR showed a lower variability than LEP (show LEP Antibodies) in the different analysed populations, especially in the Iberian breed that showed no variability

4. Superactive human leptin (show LEP Antibodies) antagonist reverses leptin (show LEP Antibodies)-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin (show LEP Antibodies) receptors.

5. The presence of leptin (show LEP Antibodies) and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

6. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

7. Data showing changes in expression patterns of LEP (show LEP Antibodies)/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP (show LEP Antibodies)/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.

8. Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin (show LEP Antibodies)

9. Leptin (show LEP Antibodies) and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin (show LEP Antibodies) mRNA expression as well as E and P on leptin (show LEP Antibodies) secretion by those cells obtained in early pregnancy.

10. These data suggest that leptin (show LEP Antibodies) might have a direct effect on porcine follicles and plays an important role in the follicular development.

Cow (Bovine) Leptin Receptor (LEPR) interaction partners

1. Here, the association between DGAT1 (show DGAT1 Antibodies) K232A, SCD1 (show SCD Antibodies) A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1 (show DGAT1 Antibodies), SCD1 (show SCD Antibodies), and LEPR polymorphisms were GC/GC (show GC Antibodies), C, and C, respectively.

2. I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression

3. The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.

4. SNP LEP (show LEP Antibodies) significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only

5. The use of leptin (show LEP Antibodies), leptin receptor, and DGAT1 (show DGAT1 Antibodies) polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.

6. The leptin (show LEP Antibodies) and receptor gene markers would be useful for marker-assisted selection.

7. The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.

8. The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.

9. the possible involvement of locally produced leptin (show LEP Antibodies)/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.

10. findings indicate that acetate and butyrate enhance leptin (show LEP Antibodies) expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries

Rhesus Monkey Leptin Receptor (LEPR) interaction partners

1. A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).