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Polymorphisms of the OSMR rs2292016 locus are related to the development and outcome of DCM.
Missense mutatios were found in exon 10 of the oncostatin-M specific receptor beta subunit (OSMR) gene in all of the six patients from family 1, and in exon 14 of the OSMR gene in all of the four patients from family 2.
The PLAC1 (show PLAC1 Proteins) expression has been demonstrated for the first time in cervical cancers. This preliminary study has further revealed a complex relationship between PLAC1 (show PLAC1 Proteins) expression, cervical cancer histologic type, p53 (show TP53 Proteins), and HPV type that requires further investigation.
OSMR-beta deficiency in macrophages improved high-fat diet-induced atherogenesis and plaque vulnerability
OSM and OSMR are highly expressed in inflammatory bowel disease intestinal mucosa compared to control mucosa. Intestinal stromal cells express abundant OSMR.
OSM:OSMR interactions are able to induce EMT (show ITK Proteins), increased cancer stem cell-like properties and enhanced lung colonisation in SCC (show CYP11A1 Proteins) cells
the RET (show RET Proteins) p.S891A mutation combined with OSMR p.G513D may underlie a novel phenotype manifesting as familial medullary thyroid carcinoma and cutaneous amyloidosis
this study offers new findings on the molecular genetics and disease relevance of mutations in OSMR in Familial primary localized cutaneous amyloidosis.
Oncostatin M (show OSM Proteins) and interleukin-31 (show IL31 Proteins): Cytokines, receptors, signal transduction and physiology.
primary localized cutaneous amyloidosis has a missense mutation in oncostatin M receptor beta
Osmr expression in healthy mouse colon tissue was detected in endothelial and stromal cells. In agreement with observations of increased OSMR expression in inflamed colon tissue, the number of cells expressing Osmr was markedly increased in the lamina propria of mice with colitis.
In astrocytes but not microglia, phosphorylation of STAT1 (show STAT1 Proteins) and STAT3 (show STAT3 Proteins) occurred in response to OSM (show OSM Proteins), whereas both microglia and astrocytes responded to hyper-IL-6 (IL-6 (show IL6 Proteins) linked to the soluble IL-6 (show IL6 Proteins) receptor).
OSM (show OSM Proteins) signaling via OSMR in synovial fibroblasts has the potential to contribute significantly to joint destruction in inflammatory arthritis.
defects in OSM (show OSM Proteins) signaling promote the deterioration of high-fat diet-induced obesity and related metabolic disorders
Data indicate that OSM (show OSM Proteins) receptor beta subunit (show POLG Proteins)-deficient (OSMRbeta(-/-)) mice exhibited phenotypic changes in adipose tissue macrophages (ATMs) to M1, increased proinflammatory cytokines in the adipose tissue, and systemic insulin (show INS Proteins) resistance.
These data indicate that the transient RANKL (show TNFSF11 Proteins) induction by intermittent PTH (show PTH Proteins) administration, which is associated with its anabolic action, is changed to a prolonged induction in OSMR-deficient osteoblasts, resulting in bone destruction.
Bone formation can be stimulated independently of bone resorption and provide new insights into OSMR signaling.
Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons.
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
IL-31 receptor subunit beta
, IL-31R subunit beta
, interleukin-31 receptor subunit beta
, oncostatin-M specific receptor beta subunit
, oncostatin-M-specific receptor subunit beta
, oncostatin receptor
, oncostatin-M specific receptor subunit beta
, oncostatin M specific receptor