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Oncostatin M Receptor Protein (OSMR) (AA 28-740) (Fc Tag)

OSMR Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Catalog No. ABIN7504493
  • Target See all Oncostatin M Receptor (OSMR) Proteins
    Oncostatin M Receptor (OSMR)
    Protein Type
    Recombinant
    Protein Characteristics
    AA 28-740
    Origin
    • 14
    • 6
    • 2
    • 1
    • 1
    Human
    Source
    • 10
    • 6
    • 4
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Oncostatin M Receptor protein is labelled with Fc Tag.
    Purpose
    Human OSMR Protein
    Sequence
    Glu28-Met740
    Characteristics
    Recombinant Human OSMR Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Glu28-Met740.
    Purity
    > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1EU per μg by the LAL method.
    Top Product
    Discover our top product OSMR Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Supplied as 0.22 μm filtered solution in PBS ( pH 7.4).
    Storage
    -80 °C
    Storage Comment
    Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Oncostatin M Receptor (OSMR)
    Alternative Name
    OSMR (OSMR Products)
    Synonyms
    OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein
    Background
    OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.
    Molecular Weight
    107.06 kDa. Due to glycosylation, the protein migrates to 120-140 kDa based on Tris-Bis PAGE result.
    Pathways
    JAK-STAT Signaling, Growth Factor Binding
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