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High incidence of activating STAT5B mutations in CD4 (show CD4 Proteins)-positive T-cell large granular lymphocyte leukemia.
STAT5 signaling drives antigen restimulation-induced T cell death in effector memory T cells
Data show that BACH2 (show BACH2 Proteins) and STAT5B are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence.
The findings, specifically frequent mutations of STAT5B, PIK3CD, and the histone methyltransferase SETD2, may help guide translational efforts to target hepatosplenic T-cell lymphoma
This is the first report of a survival disadvantage of EBV+ patients with CLL, and the first time that STAT5b expression is correlated with survival. The correlation of STAT5 (show STAT5A Proteins) expression with the presence of the virus, along with our survival correlations defines a subgroup of patients with CLL that may benefit from anti-STAT (show STAT1 Proteins) agents.
STAT5 (show STAT5A Proteins) signaling axis drives abnormal cell proliferation in autosomal dominant polycystic kidney disease.
p65 (show GORASP1 Proteins) activation triggered by TCR signaling could promote SNRPA (show SNRPA Proteins) transcription and 3' UTR shortening of STAT5B. Thus we propose that the alternative polyadenylation switching of STAT5B induced by TCR activation is mediated by SNRPA (show SNRPA Proteins).
this study shows that musculin (show MSC Proteins) inhibits human T-helper 17 cell response to interleukin 2 (show IL2 Proteins) by controlling STAT5B activity
Molecular interactions of EphA4 (show EPHA4 Proteins), growth hormone receptor (show GHR Proteins), Jak2 (show JAK2 Proteins), and STAT5B have been described.
All merkel cell carcinoma (MCC (show MCC Proteins)) cases with a good outcome expressed pSTAT5B, whereas all MCC (show MCC Proteins) cases with a poor outcome did not express pSTAT5B; hence, pSTAT5B expression may be an indicator of positive prognosis in patients with MCC (show MCC Proteins).
STAT5B is a crucial regulator of RICD in memory T cells in mice
Our work is the first to report that an active form of Stat5b restored DCs tolerogenic functions that re-educated Tregs to re-establish and to sustain long-term protective immune response against diabetes in NOD mice.
Instead, we find that STAT5B is dominant over STAT5A (show STAT5A Proteins) in CD4 (show CD4 Proteins)(+) 'helper' T cells for both effector and regulatory (Treg) responses and, therefore, uniquely necessary for immunological tolerance.
These studies establish the importance of STAT5 (show STAT5A Proteins) in macrophages during ductal morphogenesis in the mammary gland and demonstrate that altering STAT5 (show STAT5A Proteins) function in macrophages can affect the development of tissue-specific disease.
Data indicate that 89% of signal transducer and activator of transcription 5 (show STAT5A Proteins) (Stat5b)-CA mice in which the T2/Onc transposon had been mobilized died of progenitor B-cell acute lymphoblastic leukemia (B-ALL) by 3 months of age.
STAT5B and MOF (show KAT8 Proteins) work as negative regulators in adipogenesis.
Strong selective advantage for leukemic transformation in the background of Stat5 (show STAT5A Proteins) deficient hematopoiesis was permissive for faster initiation of Myc (show MYC Proteins)-induced transformation to B (show TDO2 Proteins)-ALL.
liver STAT5b activation/masculinization occurred at puberty and suppression/feminization occurred during aging and in mutant mice with defects in growth hormone signaling.
Loss of STAT5b had no effect on either sex.
SNPs in JAK2 (show JAK2 Proteins) and STAT5B are associated with mastitis susceptibility in Chinese Holstein cattle
This study suggests that growth hormone (show GH1 Proteins) inhibits the differentiation of bovine preadipocytes to adipocytes through STAT5b-dependent inhibition of C/EBPalpha (show CEBPA Proteins) and PPARgamma (show PPARG Proteins) expression.
These results suggested that the SNPs in CD4 (show CD4 Proteins) and STAT5b may be potential genetic markers for SCS (show TWIST1 Proteins) and milk/protein (show CSN2 Proteins) yields selecting and warrant further functional research.
This study indicates that CISH (show CISH Proteins) functions as a conserved in vivo target and regulator of STAT5 in the control of embryonic hematopoiesis.
study demonstrates that STAT5 in basophils is activated through both the IL-3 (show IL-3 Proteins) and the FcepsilonRI (show FCER1G Proteins) signaling pathway
Studies demonstrate a conserved role for SOCS1 (show SOCS1 Proteins) in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2 (show JAK2 Proteins)-Stat5 pathway.
The stat5.1 gene lies next to the stat3 (show STAT3 Proteins) gene.
A study of the polymorphisms of STAT5b is presented, and the use of radiation hybrid mapping to localize the gene to chromosome 12 is presented.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
transcription factor STAT5B
, Signal transducer and activator of transcription 5a
, mammary gland factor STAT5B
, signal transducer and activator of transcription 5B
, signal transducer and activator of transcription 5A
, Signal transducer and activator of transcription 5B