STAT5B Products
(Signal Transducer and Activator of Transcription 5B (STAT5B))
Categories
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008].
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Featured STAT5B Categories
STAT5B Antibodies
High quality antibodies with extensive validation data.
STAT5B ELISA Kits
Reliable ELISA kits for a wide range of species.
STAT5B Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended STAT5B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (5)
Cat. No.
ABIN563035
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IP
Validations
- (5)
Cat. No.
ABIN520547
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (5)
Cat. No.
ABIN520546
Quantity
100 μg
Datasheet
Datasheet
Recommended STAT5B ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6959478
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970221
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN1117115
Quantity
96 tests
Datasheet
Datasheet
Recommended STAT5B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125095
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321606
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321604
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our STAT5B products
: "Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells." in: Nature communications, Vol. 8, Issue 1, pp. 1320, (2018) (PubMed).: "TGF-β induces the differentiation of human CXCL13-producing CD4(+) T cells." in: European journal of immunology, Vol. 46, Issue 2, pp. 360-71, (2016) (PubMed).
: "BCR-ABL affects STAT5A and STAT5B differentially." in: PLoS ONE, Vol. 9, Issue 5, pp. e97243, (2015) (PubMed).
: "Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells." in: Molecular & cellular proteomics : MCP, Vol. 14, Issue 6, pp. 1447-63, (2015) (PubMed).
: "Granulocyte colony-stimulating factor potentiates all-trans retinoic acid-induced granulocytic differentiation in acute promyelocytic leukemia cell line HT93A." in: Cancer cell international, Vol. 15, pp. 30, (2015) (PubMed).
: "Effects of Er-Zhi-Wan on microarchitecture and regulation of Wnt/?-catenin signaling pathway in alveolar bone of ovariectomized rats." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 34, Issue 1, pp. 114-9, (2014) (PubMed).
: "Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features." in: PLoS ONE, Vol. 9, Issue 8, pp. e104265, (2014) (PubMed).
: "Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia." in: Blood, Vol. 121, Issue 22, pp. 4541-50, (2013) (PubMed).
: "Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies." in: The Journal of biological chemistry, Vol. 287, Issue 20, pp. 16596-608, (2012) (PubMed).
: "A novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (Stat5) tyrosine phosphorylation and the selective influence of Stat5B over mast cell cytokine production." in: The Journal of biological chemistry, (2011) (PubMed).
Synonyms and alternative names related to STAT5B
signal transducer and activator of transcription 5B (STAT5B), signal transducer and activator of transcription 5B (Stat5b), signal transducer and activator of transcription 5B S homeolog (stat5b.S), signal transducer and activator of transcription 5B (LOC490969), Signal transducer and activator of transcription 5B (sta5b), signal transducer and activator of transcription 5B (LOC100566752), signal transducer and activator of transcription 5B (LOC100052954), STAT5, stat5, STAT5A, STAT5BProtein level used designations for STAT5B
- transcription factor STAT5B
- Signal transducer and activator of transcription 5a
- mammary gland factor STAT5B
- signal transducer and activator of transcription 5A
- Signal transducer and activator of transcription 5B
- signal transducer and activator of transcription 5B
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