Synonyms: DKFZp586J1923, Kalikrein, Kallikrein 13, Kallikrein L4, Kallikrein Like 4, Kallikrein like 4 variant included, Kallikrein like gene 4, Kallikrein like protein 4, Kallikrein related peptidase 13, Kallikrein-13, Kallikrein-like protein 4, KLK-L4, KLK13, KLK13_HUMAN, KLKL 4, KLKL 4, KLKL4
Background: Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene. It belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. By genomic sequence analysis, KLK13 gene is mapped in a 300-kb region on chromosome 19q13.3-q13.4. It has been shown that recombinant hK13 produced in yeast can cleave synthetic peptides after the arginine residue and some extracellular matrix components. However, its exact physiological substrates and functions remain obscure. Despite the lack of knowledge on the physiological function of hK13, several studies have demonstrated that hK13 is implicated with cancer of the breast and ovary and it can serve as a favorable prognostic biomarker for these malignancies.
Gene Name: KLK13
Production: Natural and recombinant human KLK13. There is no detectable cross-reactivity with other relevant proteins.
Standard: Expression system for standard: NSO, Immunogen sequence: G17-Q277