Anti-Parietal Cell ELISA Kit
Reactivity: Human
Colorimetric
Sandwich ELISA
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- Target
- Anti-Parietal Cell
- Reactivity
- Human
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Application
- ELISA
- Analytical Method
- Quantitative
- Characteristics
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ELISA kit for the detection of Parietal Cell in the research laboratory
Alternative Names: Parietal cell ELISA kit - Purification
- Ascites, ammnonium sulphate purified
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- Application Notes
- Optimal conditions to be determined by end-user
- Plate
- Pre-coated
- Assay Procedure
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AntiParietal Cell (H+/K+ATPase) is an indirect solid phase enzyme immunometric assay (ELISA). It is designed for the quantitative measurement of IgG class autoantibodies directed against the a and bsubunits of the Parietal Cell H+/K+ATPase. Preparations of highly purified pig Parietal Cell H+/K+ATPase are coated on microplates. The microplates can be divided into 12 modules of 8 wells each or can be used completely for 96 determinations. Each well can be separated from the module (
- Restrictions
- For Research Use only
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- Storage
- 4 °C
- Storage Comment
- Store at 2-8 °C.
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- Target
- Anti-Parietal Cell
- Target Type
- Antibody
- Background
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Autoantibodies against the H/K ATPase can be detected in 80-90 % of pernicious anemia patients, by indirect immunofluorescence and they are also detected in 20 % of the healthy adult population. ELISA test systems show a sensitivity of about 80 % and specificity of about 90 %. There is an age related increase in the presence of parietal cell autoantibodies in the adult population. A study of the relationship between parietal cell autoantibody and gastric mucosal morphology, indicates these parietal cell positive individuals in a random population may indeed have early type A gastritis. Higher prevalence rates (20-30 %) of parietal cell autoantibodies have been noted in patients with autoimmune endocrine disorders such as thyrotoxicosis, Hashimoto's thyroiditis and insulin-dependent diabetes. Histological examinations of gastric biopsies reveals that the majority of parietal cell autoantibody positive individuals also have a type A gastric lesion.
Synonyms: Parietal cell ELISA kit.
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