Centromere B ELISA Kit
Reactivity: Various Species
Colorimetric
Sandwich ELISA
-
- Target
- Centromere B
- Reactivity
- Various Species
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Application
- ELISA
- Analytical Method
- Quantitative
- Characteristics
-
ELISA kit for the detection of Centromere B in the research laboratory
Alternative Names: Centromere B ELISA kit
-
- Application Notes
- Optimal conditions to be determined by end-user
- Plate
- Pre-coated
- Assay Procedure
-
AntiCentromer B is an indirect solid phase enzyme immunometric assay (ELISA). It is designed for the quantitative measurement of IgG class autoantibodies directed against Centromer B. The microplates can be divided into 12 modules of 8 wells each or can be used completely for 96 determinations. Each well can be separated from the module (
- Restrictions
- For Research Use only
-
- Storage
- 4 °C
- Storage Comment
- Store at 2-8 °C.
-
- Target
- Centromere B
- Target Type
- DNA
- Background
-
In patients suffering from CREST syndrome circulating antibodies against the centromere protein B can be detected. Up to 70 % of all CREST patients exhibit anti-centromere B autoantibodies. The determination of anti-centromere B autoantibodies is of prognostic significance in diagnosing Raynaud's phenomenon. Raynaud's phenomenon often comes out as the first symptom of scleroderma and precedes the additional manifestations by several years. Also in patients suffering from primary biliary cirrhosis (PBC) anti-centromere B antibodies can be found. PBC and CREST often overlap. Anti-centromere B are found in about 10-20 % of sera from patients with PBC preferentially identifying those patients with Raynaud's phenomenon and sclerodactyly. Along with other centromere proteins (e.g. CENPA (19 kDa), CENPC (140 kDa)) centromere protein B (80 kDa) belongs to a protein complex of the chromosomal kinetochore, the attachment site of microtuble spindles during cell division.
Synonyms: Centromere B ELISA kit.
-
You are here:
