Anti-alpha-Fodrin IgG/IgA ELISA Kit
Reactivity: Human
Colorimetric
Sandwich ELISA
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- Target
- Anti-alpha-Fodrin IgG/IgA
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Reactivity
- Human
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Application
- ELISA
- Analytical Method
- Quantitative
- Characteristics
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ELISA kit for the detection of Alpha Fodrin in the research laboratory
Alternative Names: Alpha Fodrin ELISA kit
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- Application Notes
- Optimal conditions to be determined by end-user
- Plate
- Pre-coated
- Assay Procedure
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The AntialphaFodrin IgG/IgA is an indirect solid phase enzyme immunometric assay (ELISA). The microplate is coated with human alphaFodrin. And the ELISA is designed for the quantitative measurement of IgG and IgA class autoantibodies directed against alphaFodrin. The microplate can be divided into 12 modules of 8 wells each or can be used completely for 96 determinations. Each well can be separated from the module (
- Restrictions
- For Research Use only
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- Storage
- 4 °C
- Storage Comment
- Store at 2-8 °C.
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- Target
- Anti-alpha-Fodrin IgG/IgA
- Target Type
- Antibody
- Background
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Alpha fodrin is an intracellular, actin-binding, organ-specific protein of the cytoskeleton. It is a dimer composed of an alpha and a beta subunit. The network of actin and fodrin situated below the plasma membrane of secretorial cells, is important for the alignment of secretorial vesicles to the plasma membrane during secretorial processes. During apoptosis the alpha fodrin dimer is cleaved into a 120 kDa breakdown product, which is found abundantly in the salivary gland. This proteolysis of fodrin may be a consequence of protease activation during apoptosis. The cleavage product of 120 kDa alpha fodrin was found to be an important autoantigen in the pathogenesis of organ-specific autoimmune response. Clinical studies have shown, that in patients with Sjögren Syndrome alpha fodrin is involved in the stimulation of peripheral blood Tcells. These findings suggest, that an increase in protease activity and the stimulation of T-cells play an important role in the alpha fodrin proteolysis during the development of primary Sjogren's Syndrome.
Synonyms: Alpha Fodrin ELISA kit.
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