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decreased neuronal cell SKA complex genes' expression levels affect neuronal cell viability and neurite development
study shows that decreased gene and protein expression of SKA2 observed in the prefrontal cortex of suicide victims is specific to suicide, which was not observed in the brain of nonsuicidal patients. It also indicates reduced SKA2 expression in suicide is independent of psychiatric diagnosis, since it is observed in all diagnostic groups studied.
Possible association between SKA2 expression in prefrontal cortex and MDD.
Data show that HOTAIR might act as an endogenous 'sponge' of miR-141, thereby regulating the derepression of SKA2.
The study adds evidence that CREB, a tumor oncogene, promotes renal cell carcinoma proliferation. It probably achieves this by increasing SKA2 expression
Kinetochores mature through Ska1/ska2/Ska3 complex recruitment and this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint.
p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis.
these data establish the importance of SKA2 for cortisol stress responsivity and the development of post-traumatic stress disorder and provide further evidence that SKA2 is a promising biomarker for stress-related disorders including PTSD.
Results suggest that DNA methylation(adj) of SKA2 in blood indexes stress-related psychiatric phenotypes and neurobiology, pointing to its potential value as a biomarker of stress exposure and susceptibility.
DNA methylation of the SKA2 gene has been implicated as a biomarker of suicide risk and posttraumatic stress disorder.
SKA2 is hypothesized to reduce the ability to suppress cortisol following stress.
PRR11-SKA2 bidirectional transcription unit, which is a novel direct target of NF-Y, is essential for the accelerated proliferation and motility of lung cancer cells
SKA2 significantly interacted with anxiety and stress to explain about 80% of suicidal behavior and progression from suicidal ideation to suicide attempt.SKA2 is a novel genetic and epigenetic marker involved in the etiology of suicide, suicidal behaviors
The structure of the Ska core complex is a W-shaped dimer of coiled coils, formed by intertwined interactions between Ska1, Ska2, and Ska3.
Data suggest that Aurora B phosphorylation antagonizes the interaction between the Ska1-3 complex and the KMN network, thereby controlling Ska recruitment to KTs and stabilization of KT-MT attachments.
blocking of miR-301 in A549 cells leads to a decrease in the expression of the host gene, ska2.
These data suggest that the Ska1/Ska2 complex plays a critical role in the maintenance of the metaphase plate and/or spindle checkpoint silencing.
Study discovered that FAM33A is protein partners for GRs and is involved in cell proliferation and GC signalling.
The Skas subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies.
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for ska1 localization (By similarity).
family with sequence similarity 33, member A
, spindle and KT (kinetochore) associated 2
, spindle and kinetochore-associated protein 2
, Protein FAM33A