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Human Monoclonal KLHL21 Primary Antibody for IHC, ELISA - ABIN969246
Otsuki, Ota, Nishikawa, Hayashi, Suzuki, Yamamoto, Wakamatsu, Kimura, Sakamoto, Hatano, Kawai, Ishii, Saito, Kojima, Sugiyama, Ono, Okano, Yoshikawa, Aotsuka, Sasaki, Hattori, Okumura, Nagai, Sugano et al.: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. ... in DNA research : an international journal for rapid publication of reports on genes and genomes 2005
Show all 3 Pubmed References
Data (including data from studies using cells cultured from knockout mice) suggest that Sccro (show DCUN1D1 Antibodies) neddylates Cul3 (show CUL3 Antibodies) with Nedd8 (show NEDD8 Antibodies), promoting Cul3 (show CUL3 Antibodies)/Klhl21 complex formation and localization of Cul3 (show CUL3 Antibodies) during telophase. (Sccro (show DCUN1D1 Antibodies) = squamous cell carcinoma-related oncogene (show DCUN1D2 Antibodies); Cul3 (show CUL3 Antibodies) = cullin 3 (show CUL3 Antibodies); Nedd8 (show NEDD8 Antibodies) = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 = kelch-like protein 21)
data clearly demonstrate that KLHL21 negatively regulates TNFalpha (show TNF Antibodies)-activated NF-kappaB (show NFKB1 Antibodies) signaling via targeting IKKbeta (show IKBKB Antibodies), providing new insight into the mechanisms underlying NF-kappaB (show NFKB1 Antibodies) regulation in cells.
Our study suggests that KLHL21 is a potential target for therapeutic intervention. Our findings also provide novel candidate genes on a genome-wide scale, which may have significant impact on the design and execution of effective therapy of HCC (show FAM126A Antibodies) patients.
KLHL21 localizes to midzone microtubules in anaphase & recruits aurora B (show AURKB Antibodies) & Cul3 (show CUL3 Antibodies) to this region; results suggest that different Cul3 (show CUL3 Antibodies) adaptors nonredundantly regulate aurora B (show AURKB Antibodies) during mitosis, possibly by ubiquitinating different pools of aurora B (show AURKB Antibodies)
Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).
kelch-like protein 21
, kelch-like 21 (Drosophila)
, kelch-like 21