Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Data (including data from studies using cells cultured from knockout mice) suggest that Sccro (show DCUN1D1 Proteins) neddylates Cul3 (show CUL3 Proteins) with Nedd8 (show NEDD8 Proteins), promoting Cul3 (show CUL3 Proteins)/Klhl21 complex formation and localization of Cul3 (show CUL3 Proteins) during telophase. (Sccro (show DCUN1D1 Proteins) = squamous cell carcinoma-related oncogene (show DCUN1D2 Proteins); Cul3 (show CUL3 Proteins) = cullin 3 (show CUL3 Proteins); Nedd8 (show NEDD8 Proteins) = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 = kelch-like protein 21)
data clearly demonstrate that KLHL21 negatively regulates TNFalpha (show TNF Proteins)-activated NF-kappaB (show NFKB1 Proteins) signaling via targeting IKKbeta (show IKBKB Proteins), providing new insight into the mechanisms underlying NF-kappaB (show NFKB1 Proteins) regulation in cells.
Our study suggests that KLHL21 is a potential target for therapeutic intervention. Our findings also provide novel candidate genes on a genome-wide scale, which may have significant impact on the design and execution of effective therapy of HCC (show FAM126A Proteins) patients.
KLHL21 localizes to midzone microtubules in anaphase & recruits aurora B (show AURKB Proteins) & Cul3 (show CUL3 Proteins) to this region; results suggest that different Cul3 (show CUL3 Proteins) adaptors nonredundantly regulate aurora B (show AURKB Proteins) during mitosis, possibly by ubiquitinating different pools of aurora B (show AURKB Proteins)
Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).
kelch-like protein 21
, kelch-like 21 (Drosophila)
, kelch-like 21