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anti-Human MAPRE1 Antibodies:
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Human Monoclonal MAPRE1 Primary Antibody for ELISA - ABIN524855
Nogueira da Costa, Mijal, Keen, Findlay, Wild: Proteomic analysis of the effects of the immunomodulatory mycotoxin deoxynivalenol. in Proteomics 2011
Bacillus Monoclonal MAPRE1 Primary Antibody for ICC, IF - ABIN533443
Komarova, Lansbergen, Galjart, Grosveld, Borisy, Akhmanova: EB1 and EB3 control CLIP dissociation from the ends of growing microtubules. in Molecular biology of the cell 2005
studies emphasize the importance of studying combinatorial expression of EB1 and ATIP3 genes and proteins rather than each biomarker alone. A population of highly aggressive breast tumors expressing high-EB1/low-ATIP3 may be considered for the development of new molecular therapies.
STIM1-EB1 interaction shapes the kinetics and amplitude of local store-operated Ca(2+) entry.
finding that CLIP-170 has multiple non-CAP-Gly EB1-binding modules may explain why autoinhibition of CLIP-170 GAP-Gly domains does not fully abrogate its microtubule plus-end localization. This work expands our understanding of EB1-binding motifs and their multivalent networks.
Developed a photo-inactivated EB1 variant (pi-EB1) by inserting a blue-light-sensitive protein-protein interaction module between the microtubule-binding and +TIP-binding domains of EB1. Blue-light-mediated pi-EB1 photodissociation results in rapid +TIP complex disassembly, and acutely and reversibly attenuates microtubule growth independent of microtubule end association of the microtubule polymerase CKAP5.
EB1 and dynein mediate migration in 3D by promoting microtubule dynamics, through the activity of RhoA, in microtubule-rich pseudopodial dendritic protrusions that drive cell migration in 3D
End-binding protein 1 (EB1) depletion results in a significant reduction of spindle and kinetochore-associated protein 1 (Ska1) recruitment onto microtubules and defects in mitotic chromosome alignment.
The cytotoxicity induced by EB1 gene knockdown was due to the activation and generation of reactive oxygen species by p38 mitogen-activated protein kinase..this signaling cascade, however not nuclear factor-kappaB-mediated signaling, induced the expression of cyclooxygenase-2, a key effector of apoptotic death.
ASK1- induced phosphorylation of EB1 not only increases its plus end-tracking ability, but also promotes its recruitment of CLIP170 and p150glued to astral microtubules.
A novel EB1 acetylation site regulates the dynamic structure of microtubules.
increased peripheral EB1 distribution is a critical component of the Rac1-mediated pathway and peripheral cytoskeletal remodeling essential for agonist-induced endothelial cell barrier enhancement.
In addition, EB1 phosphorylation at Y247 by Src enhances the rate of microtubule catastrophe and significantly stimulates cell migration. These findings thus demonstrate that the Src-EB1 axis plays a crucial role in regulating the crosstalk between microtubules and focal adhesions to promote cell migration.
EB1 and EB3 thus affect multiple interphase processes and have a major impact on microtubule minus end organization.
noncentrosomal MTs regulate autophagy through a cross-talk between CAMSAP2 and EB1
results suggest that EB1 cooperates with CDK5RAP2 and perhaps other SXIP-containing +TIPs in tracking growing microtubule tips.
data provide unique structural information on the interaction of EB1 with growing microtubule ends
EB1, as a microtubule plus-end tracking protein (+TIP), is a potential candidate to bridge the gap between microtubule and actomyosin dynamics.
EB1 overexpression is an early event in oral tumorigenesis and cytoplasmic EB1 accumulation is associated with poor prognosis and tumor recurrence in oral squamous cell carcinoma patients
We propose a novel mechanism by which ATIP3-EB1 interaction indirectly reduces the kinetics of EB1 exchange on its recognition site, thereby accounting for negative regulation of microtubule dynamic instability
MAPRE1 can contribute to the detection of early-stage colorectal cancer and adenomas together with other biomarkers
The authors show that the microtubule binding protein EB1 (end-binding protein 1), a key regulator of microtubule dynamics, can bind directly to filamentous actin (F-actin) F-actin.
Crosstalk between EB1 protein and Ankyrin-G is decisive for axon initial segment assembly.
We describe here a novel function for tau as a direct regulator of eb1 and eb2 proteins in differentiating neuronal cells
Data indicate that cortactin as an Src-dependent interacting partner of EB1.
Data indicate that EB1(MAPRE1) is up-regulated in osteoblasts and is required for bone cell differentiation.
MAP1B interacts directly with EB1 and EB3 (EBs), two core 'microtubule plus-end tracking proteins' ( TIPs), and sequesters them in the cytosol of developing neuronal cells.
the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability.
Detyrosination regulates CAP-Gly proteins interaction with alpha-tubulin, but not with EB1.
End binding protein 1 is required for single-cell polarization and directional cell motility.
These findings support a model where EB1 protein links microtubules to actin protrusion and cell polarity through signaling pathways involving PKC.
results show an evolutionarily conserved pathway for microtubule capture, and suggest that mDia functions as a scaffold protein for EB1 and APC to stabilize microtubules and promote cell migration.
An EB1 mutant lacking the C-terminal tail could also fully rescue CLIP dissociation kinetics, but could only partially restore CLIP accumulation at the tips, suggesting that the interaction of CLIPs with the EB tails contributes to CLIP localization.
Localization of EB1 at the centriole/basal body is required for primary cilia assembly in fibroblasts.
EB1 was highly expressed in Sertoli cells and located along microtubule bundles in Sertoli cell processes,indicating a requirement of proper microtubule arrays for Sertoli cell plasticity and function.
Results suggest that EB1 favours the lateral association of free tubulin at microtubule-sheet edges, thereby stimulating nucleation, sheet growth and closure.
Results suggest that EB1 is necessary for the early stages of muscle differentiation.
EB1 coordinates melanoma cell migration through regulating the balance between lamellipodial and filopodial protrusion.
The authors identified a CLASP1/CD2AP/EB1-containing protein complex that surrounds the Theileria annulata schizont throughout the host cell cycle. This complex also includes the schizont membrane protein Ta-p104 together with a novel secreted Theileria annulata protein (encoded by TA20980), which they term microtubule and SH3 domain-interacting protein (TaMISHIP).
The authors show that the protective caps at microtubule ends are formed by the extended binding regions of EB proteins.
EB1-tubulin interactions are mediated in part by the same tubulin acidic tails utilized by other MAPs
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.
APC-binding protein EB1
, adenomatous polyposis coli-binding protein EB1
, end-binding protein 1
, microtubule-associated protein RP/EB family member 1
, adenomatosis polyposis coli binding protein Eb1
, microtubule-associated protein, RP/EB family, member 1
, microtubule-associated protein, RP/EB family, member 1, like