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anti-Human MIS12 Antibodies:
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Human Polyclonal MIS12 Primary Antibody for IHC, IP - ABIN250751
Maehara, Takahashi, Saitoh: CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses. in Molecular and cellular biology 2010
Show all 2 Pubmed References
Human Polyclonal MIS12 Primary Antibody for IF (p), IHC (p) - ABIN872686
Ogasawara, Cheng, Inoue, Hu, Piao, Yu, Goto, Xu, Zhao, Lei, Yang, Kimura, Umegaki, Shi, Kuzuya: Cathepsin K activity controls cardiotoxin-induced skeletal muscle repair in mice. in Journal of cachexia, sarcopenia and muscle 2017
Whereas CENP-C (show CENPC1 Antibodies) recruits a single MIS12:NDC80 (show NDC80 Antibodies) complex, the authors show here that CENP-T (show CENPT Antibodies) binds one MIS12:NDC80 (show NDC80 Antibodies) and two NDC80 (show NDC80 Antibodies) complexes upon phosphorylation by the mitotic CDK1 (show CDK1 Antibodies):Cyclin B complex at three distinct CENP-T (show CENPT Antibodies) sites.
Mechanisms of mitosis-specific assembly of the checkpoint platform Knl1 (show CASC5 Antibodies)/MIS12/NDC80 (show NDC80 Antibodies) at human kinetochores.
RWD-containing proteins interact with the Mis12 complex to shape KMN network topology, as revealed by structural analysis
Direct binding of Cenp-C (show CENPC1 Antibodies) to the Mis12 complex joins the inner and outer kinetochore.
These findings support a novel role for Hsp90 (show HSP90 Antibodies)-Sgt1 (show SUGT1 Antibodies) chaperones in ensuring the fidelity of Mis12 multiprotein complex assembly.
hMIS12 has a role in mitosis and localizes at kinetochores
These results indicate that a four-subunit Mis12 complex plays an essential role in chromosome segregation in vertebrates and contributes to mitotic kinetochore assembly.
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (By similarity).
, MIS12, MIND kinetochore complex component, homolog
, homolog of yeast Mis12
, protein MIS12 homolog
, MIS12, MIND kinetochore complex component, homolog (S. pombe)
, liver regeneration-related protein LRRG112
, kinetochore protein Mis12