Browse our Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) Proteins (PAFAH1B1)

This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.

• platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (Pafah1b1)
• platelet activating factor acetylhydrolase 1b regulatory subunit 1 (PAFAH1B1)
• platelet activating factor acetylhydrolase 1b regulatory subunit 1 L homeolog (pafah1b1.L)
• platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 (Pafah1b1)

• LIS-1 protein
• Lis1 protein
• lis2 protein
• mdcr protein
• mds protein
• Show all synonym aliases
• Mdsh protein
• MMS10-U protein
• Ms10u protein
• pafah protein
• pafah1b1-b protein
• Pafaha protein

LIS-1 , PAF acetylhydrolase 45 kDa subunit , PAF-AH 45 kDa subunit , PAF-AH alpha , PAF-AH beta , PAFAH alpha , lissencephaly-1 protein , platelet-activating factor acetylhydrolase IB subunit alpha , platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta) , platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 , platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa , lissencephaly 1 protein , platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD) , platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa) , chLIS1 , lissencephaly-1 homolog , LIS1 , lissencephaly-1 homolog B , platelet-activating factor acetylhydrolase Ib-alpha subunit , Miller-Dieker syndrome chromosome region , Lissencephaly-1 protein , platelet-activating factor acetylhydrolase isoform Ib alpha subunit , platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 , platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit