Browse our Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) Proteins (PAFAH1B1)

Full name:: Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) Proteins (PAFAH1B1)

On www.antibodies-online.com are 17 Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) Proteins from 4 different suppliers available. Additionally we are shipping Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) Antibodies (80) and Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) Kits (10) and many more products for this protein. A total of 114 Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) products are currently listed.

Synonyms:: LIS-1, Lis1, lis2, mdcr, mds, Mdsh, MMS10-U, Ms10u, pafah, pafah1b1-b, Pafaha

list all proteins	Gene Name	GeneID	UniProt
	PAFAH1B1	83572	P63004
	PAFAH1B1	5048	P43034
	PAFAH1B1	18472	P63005
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Human Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) interaction partners

LIS1 promotes dynactin (show DCTN1 Proteins)-dependent tracking of dynein on both growing and shrinking plus ends. LIS1 also increases the frequency and velocity of processive dynein movements that are activated by complex formation with dynactin (show DCTN1 Proteins) and a cargo adaptor.
Microarray analysis after PAFAH1B1 knockdown and its overexpression indicated that the protein maintains Matrix Gla Protein (show MGP Proteins) expression
A novel recurrent LIS1 splice site mutation in classic lissencephaly have been found in two unrelated pediatric patients.
Lis1 has two opposing modes of regulating dynein, being capable of inducing both low and high affinity for the microtubule; study shows that these opposing modes depend on the stoichiometry of Lis1 binding to dynein and that this stoichiometry is regulated by the nucleotide state of dynein's AAA3 domain.
genetic variants in LIS1 may contribute to AML (show RUNX1 Proteins) risk in Chinese population.
Val279Phe gene polymorphisms in PAF-AH (show Lp-PLA2 Proteins) are associated with PAF-AH (show Lp-PLA2 Proteins) activity and PAF (show PAF Proteins) and GMP-140 (show SELP Proteins) levels and may be a risk factor for Henoch-Schonlein purpura with gastrointestinal bleeding
There were no significant associations between R92H and A379V variants of PAF-AH (show Lp-PLA2 Proteins) gene and risk of polycystic ovary syndrome in Chinese women.
results indicate that the NAGK-dynein interaction with the involvements of Lis1 and NudE1 plays an important role in prophase nuclear envelope breakdown (NEB) and metaphase MT-KT attachment during eukaryotic cell division.
Results showed that miR (show MLXIP Proteins)-144 was reduced in cholangiocarcinoma tissues and suggested that miR (show MLXIP Proteins)-144 may be an essential suppresser of cholangiocarcinoma cell proliferation and invasion through targeting LIS1.
LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population.

Xenopus laevis Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) interaction partners

Nudel (show NDEL1 Proteins)/NudE and Lis1 promote dynein and dynactin (show DCTN1 Proteins) interaction in the context of spindle morphogenesis.
Full rescue by the coiled-coil domain requires LIS1 binding, and increasing LIS1 concentration partly rescues aster formation

Cow (Bovine) Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) interaction partners

PAFAH Ib phospholipase A2 (show YWHAZ Proteins) subunits have distinct roles in maintaining Golgi structure and function.
Results suggest that LIS1 is essential to mediate genomic union in a process that involves the dynein-dynactin (show DCTN1 Proteins) complex.

Mouse (Murine) Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) interaction partners

This study examined the effect of Pafah1b1 overexpression on radial migration of cerebral cortical neurons and found that enhanced expression of Pafah1b1 caused over-migration of neurons into the marginal zone, and Pafah1b1-overexpressing neurons that entered the marginal zone were disoriented.
Lis1 dysfunction reduces migration and traction force production in fibroblasts.
findings suggest that Lis1 is required for germinal center (GC) B (show NPR2 Proteins) cell expansion, affinity maturation, and maintaining functional intact GC response, thus ensuring both the quantity and quality of Ab response
Lis1 plays an important role in T cell homeostasis and the generation of memory T lymphocytes.
This study demonstrated that LIS-1 regulate the septohippocampal cholinergic projection developmental.
Lis1 is required for the expansion of FL-HSCs by ensuring their genomic stability and therefore promoting their survival.
Results show that LIS1 acts via the LIS1-NDEL1 (show NDEL1 Proteins)-dynein complex to regulate astral microtubule MT plus-ends dynamics and establish proper contacts of MTs (show NEU2 Proteins) with the cell cortex to ensure precise cell division.
Conditional deletion of Lis1 in the hematopoietic system led to a severe bloodless phenotype, depletion of the stem cell pool and embryonic lethality.
Rab6a mediates LIS1 release from a LIS1-dynein complex followed by dynein activation.
LIS1 plays prominently in filopodia dynamics and dendritic spine turnover.

Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1) Protein Profile

Protein Summary

This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.

Alternative names and synonyms associated with Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1)

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (Pafah1b1)
platelet activating factor acetylhydrolase 1b regulatory subunit 1 (PAFAH1B1)
platelet activating factor acetylhydrolase 1b regulatory subunit 1 L homeolog (pafah1b1.L)
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 (Pafah1b1)

LIS-1 protein
Lis1 protein
lis2 protein
mdcr protein
mds protein
Mdsh protein
MMS10-U protein
Ms10u protein
pafah protein
pafah1b1-b protein
Pafaha protein

Protein level used designations for PAFAH1B1

, , , , , , , , , , , , , , , , , , , , , , , LIS-1 PAF acetylhydrolase 45 kDa subunit PAF-AH 45 kDa subunit PAF-AH alpha PAF-AH beta PAFAH alpha lissencephaly-1 protein platelet-activating factor acetylhydrolase IB subunit alpha platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta) platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa lissencephaly 1 protein platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD) platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa) chLIS1 lissencephaly-1 homolog LIS1 lissencephaly-1 homolog B platelet-activating factor acetylhydrolase Ib-alpha subunit Miller-Dieker syndrome chromosome region Lissencephaly-1 protein platelet-activating factor acetylhydrolase isoform Ib alpha subunit platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit

GENE ID	SPECIES
83572	Rattus norvegicus
5048	Homo sapiens
374224	Gallus gallus
399199	Xenopus laevis
397482	Sus scrofa
282513	Bos taurus
480656	Canis lupus familiaris
100135766	Felis catus
454422	Pan troglodytes
18472	Mus musculus

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