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miR-1179 inhibits the growth and invasion of non-small cell lung cancer cells by targeting SPAG5 and inhibiting Akt
Data show that increased expression of SPAG5 in hepatocellular carcinoma (HCC) was closely correlated with poor outcomes, indicating that SPAG5 serves a promising prognostic factor in HCC, and functions as an oncogene via CEP55-mediated PI3K/AKT pathway.
The importance of the SPAG5/AKT-mTOR/Wnt3 axis identified in BUC cell models.
we report the differential SPAG5 expression at both the protein and mRNA levels in Hepatocellular Carcinoma. SPAG5 may be considered a new prognostic marker for Hepatocellular Carcinoma patients, and targeting SPAG5 could provide new treatment strategies for Hepatocellular Carcinoma.
our data provide a novel evidence for the biological and clinical significance of SPAG5 as a potential biomarker, and we demonstrate that SPAG5-b-catenin-SCARA5 might be a novel pathway involved in hepatocellular carcinoma progression.
MSI2 expression is increased in epithelial cells adjacent to breast carcinoma, and increases with increasing proximity.
The authors show that the Astrin-SKAP complex binds synergistically to microtubules with the Ndc80 complex to form an integrated interface.
Data show that aurora-B regulates end-on conversion in human cells and indicate a late role for SPAG5 protein (Astrin)-SKAP complex in the end-on conversion process.
Low SPAG5 expression is associated with low chemotherapy sensitivity in breast cancer.
findings reveal a direct physical link between two important regulators of mitotic progression and demonstrate the critical role of the NuMA-Astrin interaction for accurate cell division.
Mechanistically, Plk1 acts as an upstream kinase for Astrin phosphorylation by Cdk1 and targeting phospho-Astrin to KTs, leading to the recruitment of outer KT components, such as Cenp-E, and the stable attachment of spindles to KTs.
Results showed a progression-driving role of SPAG5 in prostate cancer which can be regulated by miR-539.
Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin have been reported.
SPAG5 upregulation relates to poor prognosis in cervical cancer patients, and SPAG5 is a regulator of mTOR activity during taxol treatment in cervical cancer.
Astrin acts as a mitotic phosphoprotein during the regulation of mitosis.
Study identifies astrin as an essential negative mTORC1 regulator in the cellular stress response. Upon stress, astrin inhibits mTORC1 association and recruits the mTORC1 component raptor to stress granules, thereby preventing mTORC1-hyperactivation-induced apoptosis.
The rsults of this study the increased expression of this gene may play a pathogenic role durin testicular development in subjects with DS and cryptorchidism.
Data show that CLASP1-astrin-Kif2b complex acts as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kinetochore-microtuble attachments.
These findings suggest that the silencing of astrin induce a p53-dependent apoptosis and has an additive effect on paclitaxel treatment.
a model is proposed wherein hNinein regulates the dynamic movement of Astrin throughout the cell cycle and this interaction, in turn, is required for maintenance of centrosome/spindle pole integrity.
cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]
Loss-of-function of Astrin by RNAi and overexpression of the coiled-coil domain results in spindle disorganization, chromosome misalignment and meiosis progression arrest.
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
sperm associated antigen 5
, sperm-associated antigen 5-like
, mitotic spindle associated protein p126
, mitotic spindle coiled-coil related protein
, mitotic spindle-associated protein p126
, sperm-associated antigen 5
, microtubule-associated protein