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These data imply a complex picture where regulating factors such as OCT4 may interact with other epigenetic mechanisms to regulate USP44 expression in pluripotent stem cells and testes.
USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size
In summary, we report that the combination of USP44 expression and DNA ploidy status might serve as an independent prognostic marker in gastric cancer.
USP44 contributes to N-CoR functions in regulating gene expression and is required for efficient invasiveness of triple-negative breast cancer cells.
USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry
USP44 is epigenetically inactivated in colorectal adenomas, but this alone is not sufficient to cause aneuploidy in colorectal neoplasia.
findings implicate USP44 in negative regulation of the RNF8/RNF168 pathway
Data identify Cdc20, USP44, and Wee1 as relevant Fcp1 targets.
These data are consistent with an important role for USP44 in regulating Cdc20-APC/C activity and suggest that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemias.
a dynamic balance of ubiquitination by the APC and deubiquitination by USP44 contributes to the generation of the switch-like transition controlling anaphase entry
USP44 inhibited chromosome segregation errors independent of its role in the mitotic checkpoint by regulating centrosome separation, positioning, and mitotic spindle geometry.
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004
ubiquitin specific peptidase 44
, ubiquitin thiolesterase 44
, ubiquitin carboxyl-terminal hydrolase 44-like
, Deubiquitinating enzyme 44-A
, Ubiquitin thiolesterase 44-A
, Ubiquitin-specific-processing protease 44-A
, ubiquitin carboxyl-terminal hydrolase 44-A
, ubiquitin thioesterase 44-A
, Deubiquitinating enzyme 44-B
, Ubiquitin thiolesterase 44-B
, Ubiquitin-specific-processing protease 44-B
, ubiquitin carboxyl-terminal hydrolase 44-B
, ubiquitin thioesterase 44-B
, ubiquitin carboxyl-terminal hydrolase 44
, ubiquitin specific peptidase 49
, Deubiquitinating enzyme 44
, Ubiquitin thiolesterase 44
, Ubiquitin-specific-processing protease 44
, ubiquitin thioesterase 44
, deubiquitinating enzyme 44
, ubiquitin specific protease 44
, ubiquitin-specific-processing protease 44
, inactive deubiquitinating enzyme 44
, inactive ubiquitin carboxyl-terminal hydrolase 44
, inactive ubiquitin thioesterase 44
, inactive ubiquitin-specific-processing protease 44
, ubiquitin specific peptidase 49 pseudogene
, Ubiquitin carboxyl-terminal hydrolase 44