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Full name:: Filamin B, beta Proteins (FLNB)

On www.antibodies-online.com are 6 Filamin B, beta (FLNB) Proteins from 4 different suppliers available. Additionally we are shipping Filamin B, beta Antibodies (92) and Filamin B, beta Kits (32) and many more products for this protein. A total of 132 Filamin B, beta products are currently listed.

Synonyms:: ABP-278, ABP-280, AL024016, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP

list all proteins	Gene Name	GeneID	UniProt
	FLNB	2317	O75369
Rat FLNB	FLNB	306204
Mouse FLNB	FLNB	286940
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Human Filamin B, beta (FLNB) interaction partners

In conclusion, the authors identify filamin B as a novel host factor that can interact with core protein to promote hepatitis B virus replication in hepatocytes.
We report the case of a male patient with Larsen syndrome found to be mosaic for a novel point mutation in FLNB in whom it was possible to provide evidence-based personalized counseling on transmission risk to future offspring. Using dideoxy sequencing, a low-level FLNB c.698A>G, encoding p.(Tyr233Cys) mutation was detected in buccal mucosa and fibroblast DNA.
This is the first identified mutation in the dimerization domain of FLNB. This loss-of-function frameshift mutation in FLNB causes autosomal-recessive SCT with rarely reported rib anomalies. This report demonstrates the involvement of rib anomaly in SCT and its causative mutation in the dimerization domain of FLNB.
Our results provide evidence for the involvement of FLNB in the pathogenesis of isolated Congenital talipes equinovarusand have expanded the clinical spectrum of FLNB mutations.
FlnA (show FLNA Proteins) more strongly binds RhoA (show RHOA Proteins), although both filamins overlap with RhoA (show RHOA Proteins) expression in the cell cytoplasm. FlnA (show FLNA Proteins) promotes RhoA (show RHOA Proteins) activation whereas FlnB indirectly inhibits this pathway. Moreover, FlnA (show FLNA Proteins) loss leads to diminished expression of b1-integrin, whereas FlnB loss promotes integrin expression
splicing variants of FLNB are differentially expressed in giant cell tumor cells and may play a role in the proliferation and differentiation of tumor cells.
F-actin clustering through the interaction with the mutant FLNB actin-binding domain may limit the cytoskeletal reorganization, preventing normal skeletal development.
FLNb enhances invasion of cancer cells through phosphorylation of MRLC and FAK (show PTK2 Proteins).
Polymorphism at rs11720285, rs11130605 and rs9809315, all of which are located either 5' of the transcription start site or in intron 1 of the FLNB gene has been identified as significantly associated with BMD (show BEST1 Proteins) in Caucasian women.
study presents two patients with Atelosteogenesis Type I caused by two novel Filamin B (FLNB) mutations affecting the same FLNB residue: c.542G > A, predicting p.Gly181Asp and c.542G > C, predicting p.Gly181Arg

Mouse (Murine) Filamin B, beta (FLNB) interaction partners

These findings indicate that FLNB is involved in attenuation of TGFb/BMP signaling and influences annulus fibrosus cell fate
Fmn1 (show FMN1 Proteins) and FlnB have shared and independent functions.
Filamin a, b-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeleton.
FlnB loss reduced Cdk1 (show CDK1 Proteins) phosphorylation (an inhibitor of G2/M phase progression) and Cdk1 (show CDK1 Proteins) inhibition in chondrocytes mimicked the null FlnB, premature differentiation phenotype, through a beta1-integrin receptor- Pi3k/Akt (show AKT1 Proteins) mediated pathway.
these data demonstrate that coordinated expression of GPIbalpha (show GP1BA Proteins) and filamin (show FLNA Proteins) is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets.
Filamins A and B have a major role in the maintenance of actin-based mechanical linkages that enable endoplasmic spreading and microtubule extension as well as sustained traction forces and mature focal adhesions.
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development
disruption of the ECM (show MMRN1 Proteins)-beta1-integrin-Flnb pathway contributes to defects in vertebral and distal limb development, similar to those seen in the human autosomal recessive SCT (show SECR Proteins) due to Flnb mutations
Flnb represses chondrocyte hypertrophy in a Runx2 (show RUNX2 Proteins)/Smad3 (show SMAD3 Proteins)-dependent manner.
Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synotosis syndrome.

Filamin B, beta (FLNB) Protein Profile

Protein Summary

This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3\; boomerang dysplasia\; autosomal dominant Larsen syndrome\; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Alternative names and synonyms associated with Filamin B, beta (FLNB)

filamin B (FLNB)
filamin B (Flnb)
filamin, beta (Flnb)

ABP-278 protein
ABP-280 protein
AL024016 protein
AOI protein
FH1 protein
FLN-B protein
FLN1L protein
LRS1 protein
SCT protein
TABP protein
TAP protein

Protein level used designations for Filamin B, beta Proteins (FLNB)

ABP-280 homolog , Larsen syndrome 1 (autosomal dominant) , actin binding protein 278 , actin-binding-like protein , beta-filamin , filamin homolog 1 , filamin-3 , filamin-B , thyroid autoantigen , filamin B, beta (actin binding protein 278) , retina filamin , filamin B, beta , filamin-B-like , filamin, beta , ABP-280-like protein , FLN-B , filamin B beta

GENE ID	SPECIES
2317	Homo sapiens
378913	Gallus gallus
460476	Pan troglodytes
484713	Canis lupus familiaris
613533	Bos taurus
702732	Macaca mulatta
100008760	Oryctolagus cuniculus
100394911	Callithrix jacchus
100481308	Ailuropoda melanoleuca
306204	Rattus norvegicus
286940	Mus musculus
100722132	Cavia porcellus
101123330	Ovis aries
100514491	Sus scrofa

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