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Six putative caspase (show CASP3 Proteins) substrates, including five novel proteins (ABCF1 (show ABCF1 Proteins), AKAP1 (show AKAP1 Proteins), CPE (show CPE Proteins), DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10 (show CASP10 Proteins)]
PIST protein, mouse plays an important role in regulating the intracellular sorting/ localization of cadherin 23.
predominantly localized at the trans-Golgi region in round spermatids; male mice in which GOPC has been disrupted are infertile with globozoospermia
Gopc-deficient spermatids fail to assemble the peri (show POSTN Proteins)-nuclear structures in round-headed spermatozoa during spermatogenesis.
The coiled tail of the round-headed spermatozoa appears during epididymal passage in Gopc-deficient mice.
Transmission electron microscope (TEM (show TNMD Proteins)) images of the spermatozoa were studied quantitatively to analyze disorganization processes during epididymal passage in Gopc knockout mice.
PIST, a Golgi-associated PDZ domain-containing protein, interacts with PCDH15 (show PCDH15 Proteins) in the plasma membrane.
CAL (show FBLIM1 Proteins) can regulate the anterograde trafficking, the internalization as well as the signaling of CRFR1 (show CRHR1 Proteins) via modulating the post-translational modifications that the receptor undergoes at the Golgi apparatus.
CAL (show FBLIM1 Proteins) overexpression retards B2AR (show ADRB2 Proteins) expression in Golgi apparatus and reduces the receptor expression in the plasma membrane.
Six out of 65 (9%) BTC patients were positive for the FIG-ROS1 fusion, comprising two out of 14 (14%) gallbladder carcinoma (GBC) patients and four out of 25 (16%) extrahepatic cholangiocarcinoma (ECC) patients.
Our data suggest that PIST contributes to the fine-tuning of b1AR (show ADRB1 Proteins) sorting both during biosynthetic and postendocytic trafficking
None of 268 gliomas analysed showed the FIG-ROS1(L) rearrangement.
Stereochemical preferences modulate affinity and selectivity among CAL (show FBLIM1 Proteins) PDZ domain protein variants that bind CFTR (show CFTR Proteins).
FIG-ROS (show ROS1 Proteins) fusion protein, which is found in a subset of intrahepatic cholangiocarcinoma patients, accelerates cholangiocarcinogenesis.
Data indicate that E3 ubiquitin ligase (show MUL1 Proteins) MARCH2 (show MARCH2 Proteins) co-immunoprecipitated and co-localized with CAL (show FBLIM1 Proteins) and syntaxin 6 (STX6 (show STX6 Proteins)), and show the ubiquitination of CFTR (show CFTR Proteins) by MARCH2 (show MARCH2 Proteins).
The coiled-coil domain of PIST was then purified to homogeneity and crystallized at 293 K. Finally, X-ray diffraction data were collected to a resolution of 4.0 A from a crystal belonging to the hexagonal space group P6(2)22 or P6(4)22.
This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene.
golgi-associated PDZ and coiled-coil motif containing
, golgi associated PDZ and coiled-coil motif containing
, Golgi-associated PDZ and coiled-coil motif-containing protein
, golgi-associated PDZ and coiled-coil motif-containing protein-like
, Golgi-associated PDZ and coiled-coil motif-containing protein-like
, PDZ domain-containing protein PIST
, PDZ protein interacting specifically with TC10
, PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10
, CFTR-associated ligand
, Golgi associated PDZ and coiled-coil motif containing protein
, dJ94G16.2 PIST
, fused in glioblastoma