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summarize available knowledge of ERp57's functions in subcellular compartments and the roles of dysregulated ERp57 in various diseases.
ERp57 is involved in sperm capacitation and spermatozoa-zona pellucida binding.
Thiol isomerase ERp57 is mobilized to the surface of activated platelets via a process that requires actin polymerization.
Findings suggested that miR (show MLXIP Proteins)-330-5p represents a potential tumor-suppressive miRNA and plays an important role in cutaneous malignant melanoma progression by suppressing TYR (show TYR Proteins) and PDIA3 expression.
Our study found increased expression of ERp57 in chronic hepatitis B -hepatocellular carcinoma (HBV-HCC (show FAM126A Proteins)) genesis. Such altered expression could be related to HBV infection and high ERp57 expression may lead to poor prognosis of HBV-HCC (show FAM126A Proteins) patients.
The interaction of different flavonoids with PDIA3 was investigated by quenching fluorescence analysis and the effects on protein activity were evaluated.
Upregulation of PDIA3 promotes ovarian cancer cell proliferation and migration.
Data show that knockdown of endoplasmic reticulum resident protein 57 (ERP57) expression resulted in increase in shikonin induced apoptosis, and suggest that ERP57 might be a therapeutic option for the treatment of acute myeloid leukemia (show BCL11A Proteins).
Amyotrophic lateral sclerosis-linked PDIA3 mutations disrupt motor neuron connectivity.
These data indicate that the presence of autoantibodies to PDIA3 favors the development of an efficient and specific T-cell response against PDIA3 in colorectal cancer patients.
These results suggest that Tat (show TAT Proteins)-PDIA3 could be used to protect spinal cord neurons from ischemic damage, due to its modulatory action on the oxidative/anti-oxidative balance. Tat (show TAT Proteins)-PDIA3 could be applicable to protects neurons from the ischemic damage induced by thoracoabdominal aorta obstruction.
results demonstrate that the core circadian gene Clock regulates bone formation via transcriptional control of 1,2,5(OH)2D3 receptor PDIA3
These data indicate a synergistic crosstalk between 1alpha,25(OH)2D3 and BMP2 (show BMP2 Proteins) toward osteogenesis and mineral deposition, involving both VDR (show CYP27B1 Proteins) and Pdia3.
ERp57 deficiency causes neuromuscular defects
ERp57 levels are increased in the airway epithelium of asthmatic patients and in mice with allergic airways disease.
Data suggest that regulation of Pdia3 (protein disulfide isomerase associated 3 protein) expression by microRNA-330-5p is important in maintaining hair cycle through regulation of proliferation and migration capability of keratinocytes.
All the growth plate and bone abnormalities, however, become attenuated after the pubertal growth spurt (show BPIFA1 Proteins), when protein synthesis is decelerated and, hence, ERp57 function is less essential.
a Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-driven functional role of ENO1 and PDIA3 in alveolar epithelial cell plasticity in lung injury and repair, is reported.
ERp57 regulates thrombosis via multiple targets.
These data suggest the 25D3 -MARRS receptor/PDIA3/ERp57 may contribute to the length of lifespan in mammals.
PDIA3 may play in the progression of heart failure.
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase\; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
58 kDa glucose-regulated protein
, 58 kDa microsomal protein
, ER protein 57
, ER protein 60
, disulfide isomerase ER-60
, endoplasmic reticulum P58
, endoplasmic reticulum resident protein 57
, endoplasmic reticulum resident protein 60
, glucose regulated protein, 58kDa
, phospholipase C-alpha
, protein disulfide isomerase-associated 3
, protein disulfide-isomerase A3
, glucose regulated protein 58
, endoplasmic reticulum protein
, glucose regulated protein, 58 kDa
, phospholipase C, alpha
, ER-60 protease
, oxidoreductase ERp57
, protein disulfide isomerase associated 3
, glucose regulated protein 58kD
, 1,25D3-MARRS protein
, 1,25D3-membrane-associated, rapid-response steroid-binding protein
, 25D3-MARRS protein
, glucose regulated thiol oxidoreductase protein
, glucose-regulated thiol oxidoreductase 58 kDa protein
, rapid-response steroid-binding protein
, glucose regulated protein
, protein disulfide isomerase family A member 3 S homeolog
, protein disulfide isomerase family A, member 3