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This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1 (show MAP3K1 Proteins)-p38 (show MAPK14 Proteins), disrupts heterochromatin.
ATF-2 is critical for regulation of fat metabolism.
dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
this study demonstrates that CPEB2 (show CPEB2 Proteins) alternative splicing is a major regulator of key cellular pathways linked to anoikis resistance and metastasis.
there is a decrease in epidermal GDNF and GFRalpha-1 protein expression in normal human skin with ageing
Noxin facilitated the expression of Cyclin D1 (show CCND1 Proteins) and Cyclin E1 (show CCNE1 Proteins) through activating P38 (show CRK Proteins)-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer
In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression
In functional dyspepsia patients, duodenal expression of GDNF protein was significantly increased compared with controls. GDNF was localized in enteric glial cells, eosinophils, and epithelial cells.
these observations suggest that CD99 (show CD99 Proteins) is involved in the regulation of CD1a (show CD1A Proteins) transcription and expression by increasing ATF-2.
Suppression of miR-383 may increase the therapeutic potential of human bone-marrow-derived MSCs in treating spinal cord injury via augmentation of GDNF protein levels.
This review provides an overview of the currently known upstream regulators and downstream targets of ATF2. [review]
TNF (show TNF Proteins) induces the binding of ATF2 to the TNF (show TNF Proteins)-responsive element.
Our results suggest that GDNF rs3096140 might be involved in the genetic background of smoking, independent of anxiety characteristics.
adiponectin inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (show PRKAA1 Proteins)/PPARalpha (show PPARA Proteins)/ATF2 pathway.
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (show MAPK14 Proteins), AAT (show SERPINA1A Proteins), signal transducer and activator of transcription 1 (STAT1 (show STAT1 Proteins)) and activating transcription factor2 (ATF2)
increased expression of the gene encoding PKCepsilon (show PRKCE Proteins) and abundance of phosphorylated, transcriptionally active ATF2 were observed in advanced-stage melanomas and correlated with decreased FUK (show FUK Proteins) expression
These data identified a role for ATF2 in regulating melanocyte responses.
suppression of tumorigenesis by JNK (show MAPK8 Proteins) requires ATF2.
Taken together, our observations indicated that SOCS2 (show SOCS2 Proteins) could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (show MAPK14 Proteins) signal pathway.
ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 (show ATF3 Proteins) in M1 macrophages of White adipose tissue.
ATF-2 plays critical roles for proper expression of tyrosine hydroxylase (show TH Proteins) gene and for neurite extension of catecholaminergic neurons, possibly through repressor-like action.
these studies show that the IL-1beta (show IL1B Proteins)-induced increase in intestinal tight junction permeability was regulated by p38 (show CRK Proteins) kinase activation of ATF-2 and by ATF-2 regulation of MLCK (show MYLK Proteins) gene activity
The ATF2 represses renin (show REN Proteins) expression by drifting the transcriptional control of renin (show REN Proteins) gene away from CRE-binding protein (CREB (show CREB1 Proteins)).
ATF2-based luciferase reporter to monitor non-canonical Wnt (show WNT2 Proteins) signaling in Xenopus embryos.
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR of ATF1 (show AFT1 Proteins)/2, and indicates a difference between short and long isoforms.
Ang II (show AGT Proteins) increases endothelial arginase activity/expression through a p38 MAPK (show MAPK14 Proteins)/ATF-2 pathway leading to reduced endothelial NO production
Data indicate that Ser738/742-to-glutamate (show GRIN2A Proteins) protein kinase D (show PRKD1 Proteins) mutant increased AngII-induced CREB (show CREB1 Proteins) protein and activating transcription factor 2 phosphorylation, and phospho-CREB (show CREB1 Proteins) binding to the steroidogenic acute regulatory protein (show STAR Proteins) promoter.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro\; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.
, activating transcription factor 2 splice variant ATF2-var2
, cAMP response element-binding protein CRE-BP1
, cAMP responsive element binding protein 2, formerly
, cAMP-dependent transcription factor ATF-2
, cAMP-responsive element-binding protein 2
, cyclic AMP-dependent transcription factor ATF-2
, cyclic AMP-responsive element-binding protein 2
, activating transcription factor-2, isoform A
, activating transcription factor-2, isoform C
, activating transcription factor-2, isoform B
, cyclic AMP response element binding protein 2
, chimerin (chimaerin) 1