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p38alpha (show MAPK14 Proteins) and ATF2 expression play a crucial role in the malignant phenotypes of ovarian tumor cells and are a markers of poor prognosis in patients with ovarian serous adenocarcinomas.
activation of JNK (show MAPK8 Proteins) was found to be dependent on muscarinic acid receptor induced Ca(2 (show CA2 Proteins)+)/CAMKII (show CAMK2G Proteins) as well as ROS (show ROS1 Proteins). JNK (show MAPK8 Proteins) dependent phosphorylation of ATF2/c-Jun (show JUN Proteins) transcription factors resulted in TGF-beta (show TGFB1 Proteins) transcription and its signaling.
ATF2 regulated by miR (show MLXIP Proteins)-204 might also play an important role in the regulation of malignant behavior of glioblastoma.
We further demonstrated the suppressive function of lncRNA#32 in hepatitis B virus and hepatitis C virus infection. lncRNA#32 bound to activating transcription factor 2 (ATF2) and regulated ISG expression. Our results reveal a role for lncRNA#32 in host antiviral responses.
Results show that ATF2 is highly expressed in renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) tissues and promotes RCC (show XRCC1 Proteins) cell proliferation, migration and invasion. The study suggests that ATF2 exerts an oncogenic role in RCC (show XRCC1 Proteins).
These findings point to an oncogenic function for ATF2 in melanoma development that appears to be independent of its transcriptional activity.
this study demonstrates that CPEB2 (show CPEB2 Proteins) alternative splicing is a major regulator of key cellular pathways linked to anoikis resistance and metastasis.
Noxin facilitated the expression of Cyclin D1 (show CCND1 Proteins) and Cyclin E1 (show CCNE1 Proteins) through activating P38 (show CRK Proteins)-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer
these observations suggest that CD99 (show CD99 Proteins) is involved in the regulation of CD1a (show CD1A Proteins) transcription and expression by increasing ATF-2.
This review provides an overview of the currently known upstream regulators and downstream targets of ATF2. [review]
This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1 (show MAP3K1 Proteins)-p38 (show MAPK14 Proteins), disrupts heterochromatin.
ATF-2 is critical for regulation of fat metabolism.
dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR of ATF1 (show AFT1 Proteins)/2, and indicates a difference between short and long isoforms.
Ang II (show AGT Proteins) increases endothelial arginase activity/expression through a p38 MAPK (show MAPK14 Proteins)/ATF-2 pathway leading to reduced endothelial NO production
Data indicate that Ser738/742-to-glutamate (show GRIN2A Proteins) protein kinase D (show PRKD1 Proteins) mutant increased AngII-induced CREB (show CREB1 Proteins) protein and activating transcription factor 2 phosphorylation, and phospho-CREB (show CREB1 Proteins) binding to the steroidogenic acute regulatory protein (show STAR Proteins) promoter.
adiponectin inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (show PRKAA1 Proteins)/PPARalpha (show PPARA Proteins)/ATF2 pathway.
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (show MAPK14 Proteins), AAT (show SERPINA1A Proteins), signal transducer and activator of transcription 1 (STAT1 (show STAT1 Proteins)) and activating transcription factor2 (ATF2)
increased expression of the gene encoding PKCepsilon (show PRKCE Proteins) and abundance of phosphorylated, transcriptionally active ATF2 were observed in advanced-stage melanomas and correlated with decreased FUK (show FUK Proteins) expression
These data identified a role for ATF2 in regulating melanocyte responses.
suppression of tumorigenesis by JNK (show MAPK8 Proteins) requires ATF2.
Taken together, our observations indicated that SOCS2 (show SOCS2 Proteins) could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (show MAPK14 Proteins) signal pathway.
ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 (show ATF3 Proteins) in M1 macrophages of White adipose tissue.
ATF-2 plays critical roles for proper expression of tyrosine hydroxylase (show TH Proteins) gene and for neurite extension of catecholaminergic neurons, possibly through repressor-like action.
these studies show that the IL-1beta (show IL1B Proteins)-induced increase in intestinal tight junction permeability was regulated by p38 (show CRK Proteins) kinase activation of ATF-2 and by ATF-2 regulation of MLCK (show MYLK Proteins) gene activity
ATF2-based luciferase reporter to monitor non-canonical Wnt (show WNT2 Proteins) signaling in Xenopus embryos.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro\; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.
, activating transcription factor 2 splice variant ATF2-var2
, cAMP response element-binding protein CRE-BP1
, cAMP responsive element binding protein 2, formerly
, cAMP-dependent transcription factor ATF-2
, cAMP-responsive element-binding protein 2
, cyclic AMP-dependent transcription factor ATF-2
, cyclic AMP-responsive element-binding protein 2
, activating transcription factor-2, isoform A
, activating transcription factor-2, isoform C
, activating transcription factor-2, isoform B
, cyclic AMP response element binding protein 2
, chimerin (chimaerin) 1