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Human BCL2 Protein expressed in Wheat germ - ABIN1346542
Su, Guo, Qi: Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. in Biochimica et biophysica acta 2014
High expression of prosurvival BCL2 proteins and inhibition of apoptosis and autophagy prolongs Sertoli survival upon exposure to stress stimuli.
on the basis of data obtained during the study, it can be concluded that these polyphenols have the potential to be used as lead molecules for BCL-2 inhibition.
Tumor cell hypoxia induced Bcl-2/Twist1 (show TWIST1 Proteins) complex formation, promoting tumor cell invasion in oral squamous cell carcinoma.
Bcl-2 rs1800477A/G polymorphism may be related to the occurrence of colorectal cancer(CRC (show CALR Proteins)), and GG genotype could be a risk factor of poor prognosis in CRC (show CALR Proteins).
BTK (show BTK Proteins)-mediated signaling was found to be highly attenuated accompanied by a shift in PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and apoptosis regulation-associated genes/proteins. Cytotoxicity studies using the AKT (show AKT1 Proteins) inhibitor, MK2206+/-ibrutinib, and the Bcl-2-specific inhibitor, venetoclax+/-ibrutinib, demonstrated synergistic loss of cell viability
immunohistochemically defined cell remains a useful tool for predicting prognosis in diffuse large B-cell lymphoma when performed under optimized standardized conditions and that BCL2 expression may help to identify elderly patients at risk for relapse and who could potentially respond to anti-BCL2 targeted agents. . the coexpression of MYC (show MYC Proteins) and BCL2 does not appear to predict worse survival
OHPg/PR-B (show PGR Proteins) through Beclin-1 (show BECN1 Proteins) and Bcl2 evoke autophagy-senescence transition in breast cancer cells
our data present preliminary evidence that inherited abnormalities in the intrinsic apoptosis pathway, related to BAX (show BAX Proteins) G(-248)A and BCL2 C(-717)A SNPs, are associated with treatment response and act as independent prognostic factors in DLBCL.
BCL-2 expression is associated with oxidative stress and total antioxidant status in pediatric acute lymphoblastic leukemia.
A significant correlation between changes in the levels of expression and methylation was detected for the three apoptosis-regulatory genes (APAF1 (show APAF1 Proteins), DAPK1 (show DAPK1 Proteins), and BCL2). The results suggest that methylation play an important role in the regulation of the apoptosis system genes in breast cancer.
The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2, Mcl1 (show MCL1 Proteins), and BCL2A1 (show BCL2A1 Proteins), rather than by a single anti-apoptotic protein.
Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging.
Bcl2 is the autophagy-related target of miR (show MLXIP Proteins)-449a.
anti-apoptotic molecules BclxL (show BCL2L1 Proteins) and Bcl-2 and the pro-apoptotic factors BAD and BID (show BID Proteins) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (show FASL Proteins).
Acute ethanol exposure induced autophagy-mediated heart toxicity and injury mainly through the ROS (show ROS1 Proteins)-JNK (show MAPK8 Proteins)-Bcl-2 signaling pathway.
Th17 cells are resistant to glucocorticoid-induced apoptosis and cytokine suppression, at least in part due to high levels of BCL-2. These findings support a role of Th17 cells in glucocorticoid-resistant inflammatory conditions such as certain endotypes of asthma.
E2 protects skeletal myoblasts against apoptosis induced by H2 O2 modulating p53 (show TP53 Proteins) and FoxO (show FOXO3 Proteins) transcription factors and then their target genes Bcl-2, Bim (show BCL2L11 Proteins), Puma (show BBC3 Proteins), PERP (show PERP Proteins), and MDM2 (show MDM2 Proteins), without affecting Noxa (show PMAIP1 Proteins) gene.
Bcl-2 expression has a significant impact on the mineralogical content of enamel crystals of tooth structure
The results suggest that CARP (show ANKRD1 Proteins) can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 gene expression.
This study provides evidence from transgenic mouse models that Crebbp (show CREBBP Proteins) deletion results in deficits in B-cell development and can cooperate with Bcl2 overexpression to promote B-cell lymphoma.
These results suggest a role for mitochondrial p53 (show TP53 Proteins) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (show BAX Proteins) and Bcl2.
Zebrafish gene expressions of P53 (show TP53 Proteins), Bcl-2, Bax (show BAX Proteins) and caspase-3 (show CASP3 Proteins) were elevated after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (show S1PR1 Proteins), and ICAM1 (show ICAM1 Proteins) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 (show TP53 Proteins) expression.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (show NOTCH1 Proteins) and fish bcl-2, indicating synergy between the Notch (show NOTCH1 Proteins) pathway and the bcl2-mediated antiapoptotic pathway.
Over-expression of STC-1 (show STC1 Proteins) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (show CASP3 Proteins) production in the damaged cells. Findings from this study suggest that STC-1 (show STC1 Proteins) plays a protective role in intestinal cells through an antioxidant mechanism.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (show BAX Proteins) expression.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
role of vascular endothelial growth factor receptor-1 (show FLT1 Proteins) in Bcl-2 expression
apoptosis-inducing factor (show AIFM1 Proteins) was expressed in luminal alveolar cells and, in concert with a change in bax (show BAX Proteins) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax (show BAX Proteins), Bcl-2, caspase-3 (show CASP3 Proteins) and-7 cannot be used as a reliable apoptosis detection method.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
bcl-2 and bax (show BAX Proteins) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (show BAX Proteins)]
excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (show CASP3 Proteins) expression as well as low Bcl-2 expression.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (show BAX Proteins) and decreasing expression of bcl2.
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (show BAX Proteins).
Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (show TP53 Proteins) and decrease in the antiapoptotic BCl2 proteins.
Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (show CASP3 Proteins).
Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
apoptosis regulator Bcl-2
, protein phosphatase 1, regulatory subunit 50
, B cell lymphoma 2 associated oncogene
, B-cell leukemia/lymphoma 2
, Bcl2-like protein
, BCL2B-cell CLL/lymphoma 2
, B-cell lymphoma protein 2
, B-cell CLL/lymphoma 2
, LOW QUALITY PROTEIN: apoptosis regulator Bcl-2
, Apoptosis regulator Bcl-2