Bcl-2 Protein
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- Target See all Bcl-2 (BCL2) Proteins
- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purpose
- Active Recombinant Human Bcl-2 Protein
- Sequence
- AHAGRTGYDN REIVMKYIHY KLSQRGYEWD AGDVGAAPPG AAPAPGIFSS QPGHTPHPAA SRDPVARTSP LQTPAAPGAA AGPALSPVPP VVHLTLRQAG DDFSRRYRRD FAEMSSQLHL TPFTARGRFA TVVEELFRDG VNWGRIVAFF EFGGVMCVES VNREMSPLVD NIALWMTEYL NRHLHTWIQD NGGWDAFVEL YGPSMRPLFD
- Specificity
- Ala2-Asp211
- Purity
- > 90 % by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- < 1.0 EU/μg of the protein by LAL method.
- Top Product
- Discover our top product BCL2 Protein
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B-Cell CLL/lymphoma 2 (BCL2) (AA 1-239) protein (GST tag)
BCL2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
B-Cell CLL/lymphoma 2 (BCL2) (AA 5-205) protein (His tag)BCL2 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
B-Cell CLL/lymphoma 2 (BCL2) (AA 1-211) protein (His-IF2DI Tag)BCL2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
B-Cell CLL/lymphoma 2 (BCL2) (AA 140-239) protein (GST tag)BCL2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
B-Cell CLL/lymphoma 2 (BCL2) (AA 1-236) protein (Strep Tag)Crystallography grade BCL2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
B-Cell CLL/lymphoma 2 (BCL2) (AA 1-239) protein (Strep Tag)Crystallography grade BCL2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Buffer
- Lyophilized from a 0.22 μm filtered solution of 20 mM HEPES,50 mM KCl, pH 7.5.
- Storage
- -80 °C
- Storage Comment
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This product is stable at ≤ -70° C for up to 1 year from the date of receipt.
For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature.
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- Target
- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
- Alternative Name
- Bcl-2 (BCL2 Products)
- Synonyms
- Bcl-2 Protein, PPP1R50 Protein, bcl-2 Protein, AW986256 Protein, C430015F12Rik Protein, D630044D05Rik Protein, D830018M01Rik Protein, BCL-2 Protein, Bcl2 Protein, BCL2, apoptosis regulator Protein, B cell leukemia/lymphoma 2 Protein, B-cell CLL/lymphoma 2a Protein, B-cell CLL/lymphoma 2 protein Protein, BCL2 Protein, Bcl2 Protein, bcl2a Protein, BCL-2 Protein
- Background
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Description: This protein is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.
Name: BCL2, Bcl-2, PPP1R50, apoptosis regulator Bcl-2,Bcl-2,PPP1R50
- Gene ID
- 596
- UniProt
- P10415
- Pathways
- MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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