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anti-Human Cortactin Antibodies:
anti-Mouse (Murine) Cortactin Antibodies:
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Human Polyclonal Cortactin Primary Antibody for WB - ABIN541129
Buday, Downward: Roles of cortactin in tumor pathogenesis. in Biochimica et biophysica acta 2007
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Human Monoclonal Cortactin Primary Antibody for IHC, ELISA - ABIN965945
Fransen, Hiddink, Koelen, van Dis, Drenthen, van Binsbergen, van Woerkum: The development of a minimal intervention strategy to address overweight and obesity in adult primary care patients in The Netherlands. in Family practice 2008
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Human Monoclonal Cortactin Primary Antibody for IHC, ELISA - ABIN969073
Li, Lin, Liu, Xie: [Expression and clinical significance of EMS1 gene in gastric carcinoma]. in Ai zheng = Aizheng = Chinese journal of cancer 2008
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Human Cortactin Primary Antibody for IHC - ABIN965920
Luo, Pan, Mines, Watson, Zhang, Fan: CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis. in The Journal of biological chemistry 2006
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Human Polyclonal Cortactin Primary Antibody for IHC - ABIN965921
Salomon, Ficarro, Brill, Brinker, Phung, Ericson, Sauer, Brock, Horn, Schultz, Peters: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. in Proceedings of the National Academy of Sciences of the United States of America 2003
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Mouse (Murine) Polyclonal Cortactin Primary Antibody for ELISA, WB - ABIN257687
Paradis, Islam, Tucker, Tao, Koubi, Gendron: Tubedown associates with cortactin and controls permeability of retinal endothelial cells to albumin. in Journal of cell science 2008
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Human Monoclonal Cortactin Primary Antibody for ELISA, WB - ABIN1742565
Lai, Szczodrak, Oelkers, Ladwein, Acconcia, Benesch, Auinger, Faix, Small, Polo, Stradal, Rottner: Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases. in Molecular biology of the cell 2009
Human Polyclonal Cortactin Primary Antibody for IHC - ABIN965922
Li, Liu, Zhan: Tyrosine phosphorylation of cortactin is required for H2O2-mediated injury of human endothelial cells. in The Journal of biological chemistry 2001
Human Polyclonal Cortactin Primary Antibody for IHC, WB - ABIN362960
Head, Jiang, Li, Zorn, Schaefer, Parsons, Weed: Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. in Molecular biology of the cell 2003
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Oxidized ATM can phosphorylate cortactin at serine 113, playing a critical role in promoting breast tumor cell mobility and invasion via actin polymerization.
Data indicate that the interaction of cortactin and formin-like 2 (FMNL2) could promote the invadopodia formation and matrix degradation.
Cortactin (CTTN) silencing in megakaryocyte (MK) phenocopies histone deacetylase 6 (HDAC6) inactivation and knockdown leads to a strong proplatelet formation (PPF) defect.
Cortactin expression in carcinoma cells and its known involvement in the EGFR pathway suggest a role for this protein as a target for laryngeal squamous cell carcinoma therapy.
Cortactin depletion in HMEC-1 cells results in increased stress fibre contractility and endothelial barrier destabilisation. Secretion of the barrier-stabilising hormone adrenomedullin, which activates Rap1 and counteracts actomyosin contractility, was reduced in supernatants of cortactin-depleted endothelium. Cortactin acts in controlling actomyosin contractility with consequences for endothelial barrier integrity.
Data show that cortactin-mediated p21Cip1 nuclear export and degradation facilitating MCP1-induced human aortic smooth muscle cell (HASMC) proliferation.
Mena(INV) promotes invadopodium maturation by inhibiting normal dephosphorylation of cortactin at tyrosine 421 by the phosphatase PTP1B.
CTTN expression increases EGFR protein levels and enhances the activation of the MAPK signaling pathway. CTTN expression also inhibits the ubiquitin-mediated degradation of EGFR by suppressing the coupling of c-Cbl with EGFR.
the study revealed that PTBP1 facilitates colorectal cancer migration and invasion activities by inclusion of cortactin exon 11
Overall, the authors find that p27 directly promotes cell invasion by facilitating invadopodia turnover via the Rac1/PAK1/Cortactin pathway.
Tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA antagonist SRGAP1 to relax adherens junctions in response to HGF.
cortactin binds to E-cadherin, and that a posttranslational modification of cortactin, RhoA-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1) at S298, impairs adherens junction assembly and supports their dissolution.
Unique role for PBF in regulating CTTN function to promote endocrine cell invasion and migration.
AMPK phosphorylation of cortactin followed by SIRT1 deacetylation modulates the interaction of cortactin and cortical-actin in response to shear stress. Functionally, this AMPK/SIRT1 coregulated cortactin-F-actin dynamics is required for endothelial nitric oxide synthase subcellular translocation/activation and is atheroprotective.
These data suggest a model in which cortactin promotes exosome secretion by stabilizing cortical actin-rich multivesicular late endosome docking sites.
Cortactin may have an important role in the development of oral tumors in human
a dynamic TIP150-cortactin interaction orchestrates directional cell migration via coupling dynamic microtubule plus ends to the cortical cytoskeleton.
Study showed that dynamin 2 and cortactin participate in the formation of F-actin bundles, which stabilize filopodia in migrating cancer cells.
Amplification of 11q13 resulting in overexpression of CTTN/CCND1 was the most prominent finding, which was observed in 13 of 19 ESCC cases.
The cortactin Tyr421 residue is required to promote cell proliferation both in vitro and in vivo.
this paper shows that cortactin deficiency causes increased RhoA/ROCK1-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe dextran sulfate sodium-induced colitis
Secretion of the barrier-stabilising hormone adrenomedullin, which activates Rap1 and counteracts actomyosin contractility, was reduced in plasma from cortactin-deficient mice. Cortactin plays a role in controlling actomyosin contractility with consequences for endothelial barrier integrity.
These findings suggest that the patterning of podosomes into a sealing zone involves the dynamic interaction between cofilin, CTTN, and the microtubule + ends.
Cortactin may have an important role in the development of oral tumors in mice
findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin independently of its role in oxidant stress responses.
association of cortactin with Pfn-1 is regulated by c-Abl-mediated cortactin phosphorylation
Cell proliferation, migration and invasion were inhibited by genetic knockdown of EMS1.
our findings suggest that after GnRHa activation, src activity leads to tyrosine phosphorylation of cortactin, which facilitates its association with Arp3 to engage the actin cytoskeleton.
GIT1-cortactin association through GIT1-Spa homology domain is required for cortactin localization to the leading edge and is essential for endothelial cell directional migration and tumor angiogenesis.
Data indicate that cortactin as an Src-dependent interacting partner of EB1.
Introduction of three 4-R-hydroxyproline residues stabilizes the SH3m-cortactin binding of HPK1 peptide.
mXinalpha together with cortactin is able to modulate the p120-catenin activity for shape change and adhesion at the intercalated discs.
the formation of lamellipodia is mediated by a complex of cortactin, CD2AP, and actin capping protein
FAK-mediated focal adhesion remodeling may occur through the formation of a FAK-cortactin signaling complex.
ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation.
we demonstrate that cell spreading promotes the association of cortactin and FAK and that tyrosine phosphorylation of cortactin disrupts this interaction, which may explain how it inhibits cell spreading.
LPS modulation of cortactin stability is coordinately regulated by stress kinases and the ubiquitin-proteasomal network.
MLCK is essential for the translocation and association of cortactin and p47phox.
Cortactin is crucial for orchestrating the molecular events leading to proper endothelial barrier function and leukocyte recruitment in vivo.
our data suggest that cortactin and Arp2/3 mediated actin polymerization is implicated in the cell movement during gastrulation and perhaps the development of the central neural system as well.
These findings suggest that this common cortactin variant may functionally contribute to ALI predisposition by impeding endothelial wound healing.
Demonstrate a novel regulation and role for cortactin in FVIIa/TF-mediated endothelial cell migration that occurs through a PAR2 and RhoA dependent mechanism.
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
, oncogene EMS1
, src substrate cortactin
, mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)
, cortactin isoform B
, src substrate protein p85
, Src substrate cortactin
, src substrate cortactin-like