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anti-Human Cortactin Antibodies:
anti-Mouse (Murine) Cortactin Antibodies:
anti-Rat (Rattus) Cortactin Antibodies:
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Human Polyclonal Cortactin Primary Antibody for IHC - ABIN965921
Salomon, Ficarro, Brill, Brinker, Phung, Ericson, Sauer, Brock, Horn, Schultz, Peters: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. in Proceedings of the National Academy of Sciences of the United States of America 2003
Show all 2 Pubmed References
Human Monoclonal Cortactin Primary Antibody for IHC, ELISA - ABIN969073
Li, Lin, Liu, Xie: [Expression and clinical significance of EMS1 gene in gastric carcinoma]. in Ai zheng = Aizheng = Chinese journal of cancer 2008
Show all 2 Pubmed References
Human Cortactin Primary Antibody for IHC - ABIN965920
Luo, Pan, Mines, Watson, Zhang, Fan: CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis. in The Journal of biological chemistry 2006
Show all 4 Pubmed References
Human Monoclonal Cortactin Primary Antibody for IHC, ELISA - ABIN965945
Fransen, Hiddink, Koelen, van Dis, Drenthen, van Binsbergen, van Woerkum: The development of a minimal intervention strategy to address overweight and obesity in adult primary care patients in The Netherlands. in Family practice 2008
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Mouse (Murine) Polyclonal Cortactin Primary Antibody for ELISA, WB - ABIN257687
Paradis, Islam, Tucker, Tao, Koubi, Gendron: Tubedown associates with cortactin and controls permeability of retinal endothelial cells to albumin. in Journal of cell science 2008
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Human Monoclonal Cortactin Primary Antibody for ICC, IHC - ABIN1742566
Lai, Szczodrak, Oelkers, Ladwein, Acconcia, Benesch, Auinger, Faix, Small, Polo, Stradal, Rottner: Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases. in Molecular biology of the cell 2009
Human Polyclonal Cortactin Primary Antibody for IHC, WB - ABIN362960
Head, Jiang, Li, Zorn, Schaefer, Parsons, Weed: Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. in Molecular biology of the cell 2003
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Human Polyclonal Cortactin Primary Antibody for IHC - ABIN965922
Li, Liu, Zhan: Tyrosine phosphorylation of cortactin is required for H2O2-mediated injury of human endothelial cells. in The Journal of biological chemistry 2001
Cortactin (CTTN) silencing in megakaryocyte (MK) phenocopies histone deacetylase 6 (HDAC6 (show HDAC6 Antibodies)) inactivation and knockdown leads to a strong proplatelet formation (PPF) defect.
Cortactin expression in carcinoma cells and its known involvement in the EGFR (show EGFR Antibodies) pathway suggest a role for this protein as a target for laryngeal squamous cell carcinoma therapy.
Cortactin depletion in HMEC-1 cells results in increased st (show ADM Antibodies)ress fibre contractili (show RABGEF1 Antibodies)ty and endothelial barrier destabilisation. Secretion of the barrier-stabilising hormone adrenomedullin, which activates Rap1 and counteracts actomyosin contractility, was reduced in supernatants of cortactin-depleted endothelium. Cortactin acts in controlling actomyosin contractility with consequences for endothelial barrier integrity.
Data show that cortactin-mediated p21Cip1 (show CDKN1A Antibodies) nuclear export and degradation facilitating MCP1 (show CCL2 Antibodies)-induced human aortic smooth muscle cell (HASMC) proliferation.
Mena (show EGFR Antibodies)(INV (show INVS Antibodies)) promotes invadopodium maturation by inhibiting normal dephosphorylation of cortactin at tyrosine 421 by the phosphatase PTP1B (show PTPN1 Antibodies).
CTTN expression increases EGFR (show EGFR Antibodies) protein levels and enhances the activation of the MAPK (show MAPK1 Antibodies) signaling pathway. CTTN expression also inhibits the ubiquitin-mediated degradation of EGFR (show EGFR Antibodies) by suppressing the coupling of c-Cbl (show CBL Antibodies) with EGFR (show EGFR Antibodies).
the study revealed that PTBP1 (show PTBP1 Antibodies) facilitates colorectal cancer migration and invasion activities by inclusion of cortactin exon 11
Overall, the authors find that p27 (show PAK2 Antibodies) directly promotes cell invasion by facilitating invadopodia turnover via the Rac1 (show RAC1 Antibodies)/PAK1 (show PAK1 Antibodies)/Cortactin pathway.
Tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA (show RHOA Antibodies) antagonist SRGAP1 (show SRGAP1 Antibodies) to relax adherens junctions in response to HGF (show HGF Antibodies).
cortactin binds to E-cadherin (show CDH1 Antibodies), and that a posttranslational modification of cortactin, RhoA (show RHOA Antibodies)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (show PRKD1 Antibodies)) at S298, impairs adherens junction assembly and supports their dissolution.
this paper shows that cortactin deficiency causes increased RhoA (show RHOA Antibodies)/ROCK1 (show ROCK1 Antibodies)-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe dextran sulfate sodium-induced colitis
Secretion of the barrier-stabilising hormone adrenomedullin (show ADM Antibodies), which activates Rap1 (show TERF2IP Antibodies) and counteracts actomyosin contractility, was reduced in plasma from cortactin-deficient mice. Cortactin plays a role in controlling actomyosin contractility with consequences for endothelial barrier integrity.
These findings suggest that the patterning of podosomes into a sealing zone involves the dynamic interaction between cofilin (show CFL1 Antibodies), CTTN, and the microtubule + ends.
AMPK (show PRKAA1 Antibodies) phosphorylation of cortactin followed by SIRT1 (show SIRT1 Antibodies) deacetylation modulates the interaction of cortactin and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 Antibodies)/SIRT1 (show SIRT1 Antibodies) coregulated cortactin-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 Antibodies) subcellular translocation/activation and is atheroprotective.
Cortactin may have an important role in the development of oral tumors in mice
findings reveal that Keap1 (show KEAP1 Antibodies) regulates cell migration by affecting the subcellular localization and activity of cortactin independently of its role in oxidant stress responses.
association of cortactin with Pfn-1 (show PFN1 Antibodies) is regulated by c-Abl (show ABL1 Antibodies)-mediated cortactin phosphorylation
Cell proliferation, migration and invasion were inhibited by genetic knockdown of EMS1.
our findings suggest that after GnRHa activation, src activity leads to tyrosine phosphorylation of cortactin, which facilitates its association with Arp3 to engage the actin cytoskeleton.
GIT1-cortactin association through GIT1-Spa (show FASL Antibodies) homology domain is required for cortactin localization to the leading edge and is essential for endothelial cell directional migration and tumor angiogenesis.
our data suggest that cortactin and Arp2/3 mediated actin polymerization is implicated in the cell movement during gastrulation and perhaps the development of the central neural system as well.
These findings suggest that this common cortactin variant may functionally contribute to ALI predisposition by impeding endothelial wound healing.
Demonstrate a novel regulation and role for cortactin in FVIIa/TF-mediated endothelial cell migration that occurs through a PAR2 (show F2RL1 Antibodies) and RhoA (show RHOA Antibodies) dependent mechanism.
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
, oncogene EMS1
, src substrate cortactin
, mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)
, cortactin isoform B
, src substrate protein p85
, Src substrate cortactin
, src substrate cortactin-like