Cortactin antibody (AA 214-513)

Catalog No. ABIN6139243

This Rabbit Polyclonal antibody specifically detects Cortactin in WB. It exhibits reactivity toward Human.

Quick Overview for Cortactin antibody (AA 214-513) (ABIN6139243)

Target: Cortactin (CTTN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cortactin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Cortactin Antibody

Binding Specificity: AA 214-513

Sequence: EYQGKTEKHE SQKDYVKGFG GKFGVQTDRQ DKCALGWDHQ EKLQLHESQK DYSKGFGGKY GVQKDRMDKN ASTFEDVTQV SSAYQKTVPV EAVTSKTSNI RANFENLAKE KEQEDRRKAE AERAQRMAKE RQEQEEARRK LEEQARAKTQ TPPVSPAPQP TEERLPSSPV YEDAASFKAE LSYRGPVSGT EPEPVYSMEA ADYREASSQQ GLAYATEAVY ESAEAPGHYP AEDSTYDEYE NDLGITAVAL YDYQAAGDDE ISFDPDDIIT NIEMIDDGWW RGVCKGRYGL FPANYVELRQ

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 214-513 of human Cortactin (NP_612632.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Cortactin

Target: Cortactin (CTTN)

Alternative Name: CTTN

Background: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.,CTTN,EMS1,cortactin,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Cell Adhesion,Cytoskeleton,Microfilaments,Actins,CTTN

Molecular Weight: 57 kDa/61 kDa/70 kDa

Gene ID: 2017

UniProt: Q14247

Pathways: MAPK Signaling