Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human EIF4EBP1 Protein expressed in Escherichia coli (E. coli) - ABIN2001934
Hara, Maruki, Long, Yoshino, Oshiro, Hidayat, Tokunaga, Avruch, Yonezawa: Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. in Cell 2002
Show all 4 Pubmed References
Numerous protein kinases can be responsible for mTOR (show FRAP1 Proteins) independent 4E-BP1 phosphorylation in cancer. (Review)
PI3K (show PIK3CA Proteins) kinase activity is necessary for maintaining 4E-BP1 stability. Our results also suggest 4E-BP1 a novel biological role of regulating cell cycle G2 checkpoint in responding to IR stress in association with controlling CHK2 (show CHEK2 Proteins) phosphorylation
Findings suggest that mitotic CDK1 (show CDK1 Proteins)-directed phosphorylation of delta-4E-BP1 may yield a gain of function, distinct from translation regulation, that may be important in tumorigenesis and mitotic centrosome function.
p4EBP1 was independently predictive for pathologic complete response in PIK3CA (show PIK3CA Proteins) wild-type tumors.
Data show that 4EGI-1 compound induced apoptosis in nasopharyngeal carcinoma cells through the death receptor 5 (DR5 (show TNFRSF10B Proteins)) on 4E-BP1 dephosphorylation exerting positive influence on their anti-tumor activities.
There were significantly higher expressions of p-eIF4E (show EIF4E Proteins) and p-4EBP-1 proteins in the cases with lymph node metastasis than in those without lymph node metastasis.
4E-BP1 has tumor suppressor activity by inhibiting eIF4E (show EIF4E Proteins) and, thus, blocking mRNA translation and proliferation. This is corroborated by elevated levels of phosphorylated and hence inactive 4E-BP1, which are detected in various cancers
Rotterlin inhibits mTORC1 and 4EBP1 activity in melanoma cells, inhibiting protein synthesis and promoting cell death.
Inhibition of mTORC1-mediated 4EBP1 phosphorylation leads to decreased expression of c-MYC (show MYC Proteins) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 Proteins) family member PUMA (show BBC3 Proteins), whereas inhibition of mTORC2 (show CRTC2 Proteins) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (show EGR1 Proteins)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (show BCL2L11 Proteins) locus encoding BIM (show BCL2L11 Proteins).
p-4E-BP1 is more highly expressed in early gastric cancers than in advanced ones, and has limited potential as an independent prognostic biomarker in patients with gastric cancer.
our results show that the phosphorylation of 4E-BP1 promotes translation at the onset of meiosis to support the spindle assembly and suggest an important role of CDK1 (show CDK1 Proteins) and mTOR (show FRAP1 Proteins) kinases in this process
Lack of Def6 (show DEF6 Proteins) results in deregulation of Bcl6 (show BCL6 Proteins) protein synthesis in T cells as a result of enhanced activation of the mTORC1-4E-BP-eIF4E (show EIF4E Proteins) axis.
decreasing cap-dependent translation by expressing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) prevents neuronal misplacement and soma enlargement, while partially rescuing dendritic hypertrophy induced by hyperactive mTORC1.
we show that simultaneous inhibition of mTOR (show FRAP1 Proteins) signaling to both S6K1 (show RPS6KB1 Proteins) and 4E-BP1 is sufficient to reduce AKT (show AKT1 Proteins)-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin
4E-BP1 is a gender-specific suppressor of obesity that regulates insulin (show INS Proteins) sensitivity and energy metabolism.
The authors now show that West Nile virus growth and protein expression are dependent on mTORC1 mediated-regulation of the eukaryotic translation initiation factor 4E-binding protein/eukaryotic translation initiation factor 4E-binding protein (4EBP/eIF4E (show EIF4E Proteins)) interaction and eukaryotic initiation factor (show EIF4G1 Proteins) 4F (eIF4F (show EIF4A2 Proteins)) complex formation to support viral growth and viral protein expression.
p-mTOR (show FRAP1 Proteins), p-4EBP1, HIF-1alpha (show HIF1A Proteins) and VEGF (show VEGFA Proteins) together are involved in the pathogenesis of asthma.
Thus, translational control by 4E-BP1 downstream of mTOR (show FRAP1 Proteins) effects the expression of neuroligin 1 (show NLGN1 Proteins) and excitatory synaptic transmission in the spinal cord, and thereby contributes to enhanced mechanical nociception.
The findings support a model whereby elevated 4E-BP1 expression observed in the retina of diabetic rodents is the result of O-GlcNAcylation of 4E-BP1 within its PEST motif.
The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.
Here, the authors show that cell autonomous insulin (show INS Proteins) signaling within the Drosophila CM9 motor neuron regulates the release of neurotransmitter via alteration of the synaptic vesicle fusion machinery. This effect of insulin (show INS Proteins) utilizes the FOXO-dependent regulation of the thor gene, which encodes the Drosophila homologue of the eif-4e binding protein (4eBP).
GCN2 and ATF4 are important regulators of 4E-BP transcription during normal drosophila development and aging.
longevity assurance mutants of chico, the Drosophila insulin receptor (show INSR Proteins) substrate homolog, require Drosophila d4eBP to slow aging.
These results indicate that the Ccr4-Not complex controls expression of 4E-BP at multiple levels and adjusts the magnitude of the total effect.
eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E (show EIF4E Proteins) to repress translation.
PcG proteins can directly modulate cell growth in Drosophila, in part by regulating Thor expression
These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging.
Induction of 4EBP likely leads to growth inhibition by Dfoxo, whereas activation of InR (show INSR Proteins) provides a novel transcriptionally induced feedback control mechanism.
S6 kinase (dS6K) and a single 4E-BP (d4E-BP) are phosphorylated via the insulin and target of rapamycin (TOR) signaling pathways.
Drosophila 4E-BP activity becomes critical for survival under dietary restriction and oxidative stress, and is linked to life span.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR (show FRAP1 Proteins)-RPS6K-RPS6 (show RPS6 Proteins)-EIF4EBP1 signal transduction pathway.
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
eIF4E-binding protein 1
, eukaryotic translation initiation factor 4E-binding protein 1
, phosphorylated heat- and acid-stable protein regulated by insulin 1
, Eif4e-binding protein
, eIF-4E-binding protein
, eif4e-binding protein 4EBP
, eukaryotic initiation factor 4E binding protein
, eukaryotic initiation factor 4E-binding protein
, eukaryotic translation initiation factor 4E binding protein
, eukaryotic translation initiation factor 4E-binding protein
, insulin-stimulated eIF-4E binding protein
, lethal (2) 06270
, eukaryotic translation initiation factor 4E binding protein 1
, translation initiation factor 4E binding protein 1