eIF4EBP1 Protein (His tag)

Catalog No. ABIN7318423

Product Details

Target: eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This eIF4EBP1 protein is labelled with His tag.

Purpose: Recombinant Human 4E-BP1/EIF4EBP1 Protein (His Tag)

Sequence: Met 1-Ile118

Characteristics: Recombinant Human Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Ile118 is expressed with a 6His tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Alternative Name: 4E-BP1/EIF4EBP1 (EIF4EBP1 Products)

Synonyms: 4E-BP1 Protein, 4EBP1 Protein, BP-1 Protein, PHAS-I Protein, 4e-bp1 Protein, AA959816 Protein, 153432_at Protein, 43-BP Protein, 4E-BP Protein, 4EBP Protein, 4e-bp Protein, 4eBP Protein, 4ebp Protein, BcDNA.HL08053 Protein, BcDNA:HL08053 Protein, CG8846 Protein, CT8705 Protein, Dm 4E-BP Protein, Dmel\\CG8846 Protein, Phas1 Protein, Thor/EIF4EBP Protein, anon-WO0172774.158 Protein, d4E-BP Protein, d4E-BP1 Protein, d4EBP Protein, d4e-bp Protein, d4eBP Protein, dthor Protein, eIF4E-BP Protein, l(2)06270 Protein, l(2)k07736 Protein, l(2)k13517 Protein, pp20 Protein, thor Protein, EIF4EBP1 Protein, fc04h09 Protein, wu:fc04h09 Protein, zgc:64137 Protein, eukaryotic translation initiation factor 4E binding protein 1 Protein, CG8846 gene product from transcript CG8846-RA Protein, EIF4EBP1 Protein, Eif4ebp1 Protein, Thor Protein, eif4ebp1 Protein

Background:

Background: Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) is a number of the eIF4E-binding protein family. 4EBP1 regulates eIF4E activity by preventing its assembly into the eIF4F complex. 4EBP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Non-phosphorylated 4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E. 4EBP1 is phosphorylated in response to various signals including insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. 4EBP1 has a role in progression of breast neoplasms through cell signaling.

Synonym: Eukaryotic Translation Initiation Factor 4E-Binding Protein 1, 4E-BP1, eIF4E-Binding Protein 1, Phosphorylated Heat- and Acid-Stable Protein Regulated by Insulin 1, PHAS-I, EIF4EBP1,4E-BP1,4EBP1,BP-1

Molecular Weight: 14.7 kDa

UniProt: Q13541

Pathways: MAPK Signaling, PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Cell Size, BCR Signaling