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anti-Human ERK2 Antibodies:
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Human Polyclonal ERK2 Primary Antibody for WB - ABIN966091
Li, Wysk, Gonzalez, Davis: Genomic loci of human mitogen-activated protein kinases. in Oncogene 1994
Show all 6 Pubmed References
Human Polyclonal ERK2 Primary Antibody for FACS, IHC (p) - ABIN1882175
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... in The Journal of biological chemistry 2004
Show all 5 Pubmed References
Human Monoclonal ERK2 Primary Antibody for ICS - ABIN1176894
Davis: The mitogen-activated protein kinase signal transduction pathway. in The Journal of biological chemistry 1993
Show all 4 Pubmed References
Human Monoclonal ERK2 Primary Antibody for WB - ABIN1882240
Sgouras, Athanasiou, Beal, Fisher, Blair, Mavrothalassitis: ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. in The EMBO journal 1995
Show all 5 Pubmed References
Human Monoclonal ERK2 Primary Antibody for ICC, IHC - ABIN1724654
Hatano, Mori, Oh-hora, Kosugi, Fujikawa, Nakai, Niwa, Miyazaki, Hamaoka, Ogata: Essential role for ERK2 mitogen-activated protein kinase in placental development. in Genes to cells : devoted to molecular & cellular mechanisms 2003
Show all 2 Pubmed References
Human Monoclonal ERK2 Primary Antibody for WB - ABIN533235
Rodriguez-Viciana, Tetsu, Tidyman, Estep, Conger, Cruz, McCormick, Rauen: Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. in Science (New York, N.Y.) 2006
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Human Monoclonal ERK2 Primary Antibody for IHC, ELISA - ABIN966090
Whitehurst, Robinson, Moore, Cobb: The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. in The Journal of biological chemistry 2004
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Human Polyclonal ERK2 Primary Antibody for WB - ABIN5518657
Li, Chen, Zhang, Chen, Nie, Xu, Gong, Shen, Su, Weng, Tan, Zhao, Zeng, Zhou: SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway. in International journal of clinical and experimental pathology 2015
Show all 2 Pubmed References
Human Polyclonal ERK2 Primary Antibody for WB - ABIN3042634
Ma, Wang, Chen, Chen, Wang, Aisa: Icariin and icaritin stimulate the proliferation of SKBr3 cells through the GPER1-mediated modulation of the EGFR-MAPK signaling pathway. in International journal of molecular medicine 2014
Show all 2 Pubmed References
Human Monoclonal ERK2 Primary Antibody for ICS - ABIN1176893
Sivaraman, Wang, Nuovo, Malbon: Hyperexpression of mitogen-activated protein kinase in human breast cancer. in The Journal of clinical investigation 1997
that eukaryotic elongation factor 2 kinase (show EEF2K Antibodies) might inhibit TGF-beta1 (show TGFB1 Antibodies)-induced normal lung fibroblast (NHLF) proliferation and differentiation and activate NHLF cell apoptosis and autophagy through p38 MAPK (show MAPK14 Antibodies) signaling
The activation of p38 (show CRK Antibodies) in response to low doses of ultraviolet radiation was postulated to be protective for p53 (show TP53 Antibodies)-inactive cells. Therefore, MCPIP1 (show ZC3H12A Antibodies) may favor the survival of p53 (show TP53 Antibodies)-defective HaCaT cells by sustaining the activation of p38 (show CRK Antibodies).
the present study demonstrated that scopoletin inhibited MMP1 (show MMP1 Antibodies) and proinflammatory cytokine expression by inhibiting p38 MAPK (show MAPK14 Antibodies) phosphorylation.
High MAPK1 (show MAPK3 Antibodies) expression is associated with Prostate Cancer.
Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis.
MiR (show MLXIP Antibodies)-451, which is down-regulated in human gastric cancer samples, potently modulated multiple metastatic phenotypes including cell migration, invasion, proliferation, and epithelial-mesenchymal transition. These effects were achieved via down-regulation of the miR (show MLXIP Antibodies)-451 target gene, ERK2.
These results demonstrate that betaine acts through ERK1/2-PPARgamma (show PPARG Antibodies) signalling pathway to regulate lipid metabolism in adipogenic-differentiated skeletal muscle cells, which could provide some useful information for controlling muscle lipid accumulation by manipulating ERK1/2 and PPARgamma (show PPARG Antibodies) signalling pathway.
Autophagy protects bone marrow mesenchymal stem cells from palmitate-induced apoptosis through the reactive oxygen speciesJNK/p38 MAPK (show MAPK14 Antibodies) signaling pathways.
The present study demonstrated that the downregulation of filaggrin (show FLG Antibodies) in the epidermis by toluene is mediated by ERK1/2 and STAT3 (show STAT3 Antibodies)-dependent pathways.
The results of the present study suggested that the therapeutic effect of TGP (show TGM4 Antibodies) on psoriasis may be mediated by modulation of the p38 MAPK (show MAPK14 Antibodies)/NFkappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies) signaling pathway. The results of the present study contribute to the understanding of the role of TGP (show TGM4 Antibodies) in the treatment of psoriasis. The present study provides insights suggesting that p38 MAPK (show MAPK14 Antibodies) may be a novel regulatory signaling pathway for the treatment of psoriasis.
M-CSF (show CSF1R Antibodies)-evoked ERK1/2 activation was decreased, whereas AKT (show AKT1 Antibodies) activation was enhanced in SHP2 (show PTPN11 Antibodies)-deficient BMMs. ERK1/2, via its downstream target RSK2 (show RPS6KA3 Antibodies), mediates this negative feedback by negatively regulating phosphorylation of M-CSF (show CSF1R Antibodies) receptor at Tyr721 and, consequently, its binding to p85 (show ECM1 Antibodies) subunit of PI3K and PI3K activation.
ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in colorectal cancer.
MAPKs play a critical role in the control of cellular responses to cytokines and stressors and involved in the LPS (show TLR4 Antibodies)-induced signaling pathway by which iNOS (show NOS2 Antibodies) is expressed.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (show CRK Antibodies) Pathways and the Interaction with Cell-Surface-HSP70 (show HSP70 Antibodies)
persistent distention/stretch on colonic smooth muscle cells could suppress SCF (show KITLG Antibodies) production probably through Ca(2 (show CA2 Antibodies)+) -ERK (show EPHB2 Antibodies)-AP-1 (show JUN Antibodies)-miR (show MLXIP Antibodies)-34c deregulation.
This indicates that TcpC may promote MIP2 (show CXCL2 Antibodies) production in kidney cells through the p38 MAPK (show MAPK14 Antibodies) signaling pathway. Taken together, the data of the present study demonstrated that TcpC can induce MIP2 (show CXCL2 Antibodies) production, which may contribute to the characteristic histological change associated with pyelonephritis.
the hippocampal MAPK oscillation and theta rhythmic oscillations in Nf1 (show NF1 Antibodies) (+/-) mice were disturbed and hinted about a possible mechanism for the brain dysfunction in Nf1 (show NF1 Antibodies) (+/-) mice.
Stress-specific p38 MAPK (show MAPK14 Antibodies) activation is sufficient to drive EGFR (show EGFR Antibodies) endocytosis but not its nuclear translocation
This indicated that RANK might be the binding target of baicalin. In sum, our findings revealed baicalin increased osteoclast maturation and function via p-ERK (show EPHB2 Antibodies)/Mitf (show MITF Antibodies) signalling. In addition, the results suggest that baicalin can potentially be used as a natural product for the treatment of bone fracture
ERK2 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
The present results suggest that demecolcine might contribute to the activation of the Mos (show MOCOS Antibodies)/MAPK pathway and affect spindle structure
MAPK1 upregulated milk protein (show CSN2 Antibodies) synthesis through the Stat5 (show STAT5A Antibodies) and mTOR (show FRAP1 Antibodies) pathways.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Cyclin-dependent kinase (show CDK1 Antibodies) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (show MSLN Antibodies)) and MAPK, and had nearly no effect on kinase activities during maturation.
Thrombospondin 1 (show THBS1 Antibodies), fibronectin (show FN1 Antibodies), and vitronectin (show VTN Antibodies) are differentially dependent upon RAS, ERK1/2, and p38 (show MAPK14 Antibodies) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Antibodies) nuclear accumulation.
Role of CaMKII (show CAMK2G Antibodies) in hydrogen peroxide activation of p38 MAPK (show MAPK14 Antibodies)/heat shock protein 27 pathway and ERK1/2
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
MAPK1 role in the oocyte maturation
Excess PLAC8 promotes an unconventional ERK2-dependent EMT (show ITK Antibodies) in colon cancer.
ERK1/2-Akt1 (show AKT1 Antibodies) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (show SH3GL1 Antibodies) plays an important role in the development of the myeloid cell through activation of the ERK1 (show MAPK3 Antibodies)/ERK2 pathway
ERK1 (show MAPK3 Antibodies) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.
These results demonstrate that induction of Hsp70 (show HSPA1A Antibodies) in response to heat stress is dependent on ERK activation in Pac2 (show PSMG2 Antibodies) cells.
Data define distinct roles for ERK1 (show MAPK3 Antibodies) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
The reciprocal feedback observed between MPF (show MSLN Antibodies) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.
The data suggest a MKK3 * MPK1 * RBK1 phosphorylation cascade that may provide a dynamic module for altering cell expansion.
MKP1 (show DUSP1 Antibodies) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.
MKP1 (show DUSP1 Antibodies) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (show MAPK3 Antibodies)- and MPK6 (show MAPK6 Antibodies)-dependent manner.
Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Agonist stimulation of vascular smooth muscle increases PKC (show FYN Antibodies) activity, which, in turn, increases MKP-1 (show DUSP1 Antibodies) activity and maintains MAPK1 activity at submaximal values.
sub-vasomotor concentration of ET-1 (show EDN1 Antibodies) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Antibodies) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Antibodies) following ETA receptor activation
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (show CSF2 Antibodies) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (show FRAP1 Antibodies) signal transduction cascades.
PGRN (show GRN Antibodies) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (show PPARG Antibodies) phosphorylation.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (show MAPK8 Antibodies)/2 dependent.
The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
, MAP kinase 1
, MAP kinase 2
, MAP kinase isoform p42
, MAPK 2
, extracellular signal-regulated kinase 2
, mitogen-activated protein kinase 2
, protein tyrosine kinase ERK2
, MAPK 1
, mitogen activated protein kinase 1
, extracellular-signal-regulated kinase 2
, mitogen-activated protein kinase 1
, MAP kinase
, mitogen-activated protein kinase 1b
, myelin basic protein kinase-like protein
, mitogen-activated protein kinase 1a
, extracellular signal-regulated kinase-2
, extracellular regulated protein 2