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anti-Human ERK2 Antibodies:
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Human Polyclonal ERK2 Primary Antibody for WB - ABIN966091
Li, Wysk, Gonzalez, Davis: Genomic loci of human mitogen-activated protein kinases. in Oncogene 1994
Show all 6 Pubmed References
Human Polyclonal ERK2 Primary Antibody for FACS, IHC (p) - ABIN1882175
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... in The Journal of biological chemistry 2004
Show all 5 Pubmed References
Human Monoclonal ERK2 Primary Antibody for ICS - ABIN1176894
Davis: The mitogen-activated protein kinase signal transduction pathway. in The Journal of biological chemistry 1993
Show all 4 Pubmed References
Human Monoclonal ERK2 Primary Antibody for WB - ABIN1882240
Sgouras, Athanasiou, Beal, Fisher, Blair, Mavrothalassitis: ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. in The EMBO journal 1995
Show all 5 Pubmed References
Human Polyclonal ERK2 Primary Antibody for WB - ABIN3042634
Li, Chen, Zhang, Chen, Nie, Xu, Gong, Shen, Su, Weng, Tan, Zhao, Zeng, Zhou: SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway. in International journal of clinical and experimental pathology 2015
Show all 2 Pubmed References
Human Monoclonal ERK2 Primary Antibody for IHC, ELISA - ABIN966090
Whitehurst, Robinson, Moore, Cobb: The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. in The Journal of biological chemistry 2004
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Human Monoclonal ERK2 Primary Antibody for ICC, IHC - ABIN1724654
Hatano, Mori, Oh-hora, Kosugi, Fujikawa, Nakai, Niwa, Miyazaki, Hamaoka, Ogata: Essential role for ERK2 mitogen-activated protein kinase in placental development. in Genes to cells : devoted to molecular & cellular mechanisms 2003
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Human Monoclonal ERK2 Primary Antibody for WB - ABIN533235
Rodriguez-Viciana, Tetsu, Tidyman, Estep, Conger, Cruz, McCormick, Rauen: Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. in Science (New York, N.Y.) 2006
Show all 2 Pubmed References
Human Polyclonal ERK2 Primary Antibody for WB - ABIN5518657
Ma, Wang, Chen, Chen, Wang, Aisa: Icariin and icaritin stimulate the proliferation of SKBr3 cells through the GPER1-mediated modulation of the EGFR-MAPK signaling pathway. in International journal of molecular medicine 2014
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Dog (Canine) Monoclonal ERK2 Primary Antibody for EIA, WB - ABIN126833
Samuels, Karlo, Faruzzi, Pickering, Herrup, Sweatt, Saitta, Landreth: Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
the MAPKspecific inhibitor SB203580 attenuated the inhibitory effects of 4HPR on the migration of HepG2 cells. Moreover, we also observed that 4HPR inhibited the activation and expression of myosin light chain kinase (MLCK (show MYLK Antibodies)) in HepG2 cells.
Summarizing the obtained results we can postulate p38 (show CRK Antibodies) implication in H2O2-induced senescence of hMESCs, and suggest p38 (show CRK Antibodies) inhibition as a promising approach in prevention of premature senescence.
TGFB1 (show TGFB1 Antibodies)-mediated PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) and p38 MAP kinase (show MAPK14 Antibodies) dependent alternative splicing of fibronectin (show FN1 Antibodies) extra domain A in human podocyte culture has been reported.
These data suggest ebselen may inhibit ROS (show ROS1 Antibodies) production triggered by H. pylori LPS (show IRF6 Antibodies) treatment via GPX2 (show GPX2 Antibodies)/4 instead of TLR4 (show TLR4 Antibodies) signaling and reduce phosphorylation of p38 MAPK (show MAPK14 Antibodies), resulting in altered production of IL8 (show IL8 Antibodies). Ebselen may, therefore, be a potential therapeutic agent to mediate H. pylori LPS (show IRF6 Antibodies)-induced cell damage.
SHP-2 (show PTPN11 Antibodies) may augment the ERK1/2 activity and cell proliferation activity in IL-21 (show IL17C Antibodies) signaling.
intact keratin filaments are regulators for PKB/Akt (show AKT1 Antibodies) and p44 (show GTF2H2 Antibodies)/42 activity, basal and in response to stretch.
High MAPK1 (show MAPK3 Antibodies) expression is associated with gastric cancer.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38 (show CRK Antibodies)/TRAF-6 (show TRAF6 Antibodies)/ERK (show EPHB2 Antibodies) MAP kinases pathways has been reported.
activation-loop phosphorylation does not change the average conformation of p38 (show CRK Antibodies); rather it quenches the loop ps-ns dynamics.
ntermediate Molecular Mass Hyaluronan and CD44 (show CD44 Antibodies) interactions on PMNs potently elicit F-actin cytoskeleton polymerization and p38 (show CRK Antibodies)- and ERK1/2-MAPK phosphorylation to enhance PMN (show TBCE Antibodies) function.
ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in colorectal cancer.
MAPKs play a critical role in the control of cellular responses to cytokines and stressors and involved in the LPS (show TLR4 Antibodies)-induced signaling pathway by which iNOS (show NOS2 Antibodies) is expressed.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (show CRK Antibodies) Pathways and the Interaction with Cell-Surface-HSP70 (show HSP70 Antibodies)
persistent distention/stretch on colonic smooth muscle cells could suppress SCF (show KITLG Antibodies) production probably through Ca(2 (show CA2 Antibodies)+) -ERK (show EPHB2 Antibodies)-AP-1 (show JUN Antibodies)-miR (show MLXIP Antibodies)-34c deregulation.
This indicates that TcpC may promote MIP2 (show CXCL2 Antibodies) production in kidney cells through the p38 MAPK (show MAPK14 Antibodies) signaling pathway. Taken together, the data of the present study demonstrated that TcpC can induce MIP2 (show CXCL2 Antibodies) production, which may contribute to the characteristic histological change associated with pyelonephritis.
the hippocampal MAPK oscillation and theta rhythmic oscillations in Nf1 (show NF1 Antibodies) (+/-) mice were disturbed and hinted about a possible mechanism for the brain dysfunction in Nf1 (show NF1 Antibodies) (+/-) mice.
Stress-specific p38 MAPK (show MAPK14 Antibodies) activation is sufficient to drive EGFR (show EGFR Antibodies) endocytosis but not its nuclear translocation
This indicated that RANK might be the binding target of baicalin. In sum, our findings revealed baicalin increased osteoclast maturation and function via p-ERK (show EPHB2 Antibodies)/Mitf (show MITF Antibodies) signalling. In addition, the results suggest that baicalin can potentially be used as a natural product for the treatment of bone fracture
ERK2 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
Suppressing P38 (show CRK Antibodies) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK (show MAPK8 Antibodies) weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
The present results suggest that demecolcine might contribute to the activation of the Mos (show MOCOS Antibodies)/MAPK pathway and affect spindle structure
MAPK1 upregulated milk protein (show CSN2 Antibodies) synthesis through the Stat5 (show STAT5A Antibodies) and mTOR (show FRAP1 Antibodies) pathways.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Cyclin-dependent kinase (show CDK1 Antibodies) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (show MSLN Antibodies)) and MAPK, and had nearly no effect on kinase activities during maturation.
Thrombospondin 1 (show THBS1 Antibodies), fibronectin (show FN1 Antibodies), and vitronectin (show VTN Antibodies) are differentially dependent upon RAS, ERK1/2, and p38 (show MAPK14 Antibodies) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Antibodies) nuclear accumulation.
Role of CaMKII (show CAMK2G Antibodies) in hydrogen peroxide activation of p38 MAPK (show MAPK14 Antibodies)/heat shock protein 27 (show HSP27 Antibodies) pathway and ERK1/2
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
MAPK1 role in the oocyte maturation
Excess PLAC8 promotes an unconventional ERK2-dependent EMT (show ITK Antibodies) in colon cancer.
ERK1/2-Akt1 (show AKT1 Antibodies) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (show SH3GL1 Antibodies) plays an important role in the development of the myeloid cell through activation of the ERK1 (show MAPK3 Antibodies)/ERK2 pathway
ERK1 (show MAPK3 Antibodies) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.
These results demonstrate that induction of Hsp70 (show HSPA1A Antibodies) in response to heat stress is dependent on ERK activation in Pac2 (show PSMG2 Antibodies) cells.
Data define distinct roles for ERK1 (show MAPK3 Antibodies) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
The reciprocal feedback observed between MPF (show MSLN Antibodies) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.
The data suggest a MKK3 * MPK1 * RBK1 phosphorylation cascade that may provide a dynamic module for altering cell expansion.
MKP1 (show DUSP1 Antibodies) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.
MKP1 (show DUSP1 Antibodies) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (show MAPK3 Antibodies)- and MPK6 (show MAPK6 Antibodies)-dependent manner.
Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Agonist stimulation of vascular smooth muscle increases PKC (show FYN Antibodies) activity, which, in turn, increases MKP-1 (show DUSP1 Antibodies) activity and maintains MAPK1 activity at submaximal values.
sub-vasomotor concentration of ET-1 (show EDN1 Antibodies) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Antibodies) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Antibodies) following ETA receptor activation
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (show CSF2 Antibodies) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (show FRAP1 Antibodies) signal transduction cascades.
PGRN (show GRN Antibodies) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (show PPARG Antibodies) phosphorylation.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (show MAPK8 Antibodies)/2 dependent.
The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
, MAP kinase 1
, MAP kinase 2
, MAP kinase isoform p42
, MAPK 2
, extracellular signal-regulated kinase 2
, mitogen-activated protein kinase 2
, protein tyrosine kinase ERK2
, MAPK 1
, mitogen activated protein kinase 1
, extracellular-signal-regulated kinase 2
, mitogen-activated protein kinase 1
, MAP kinase
, mitogen-activated protein kinase 1b
, myelin basic protein kinase-like protein
, mitogen-activated protein kinase 1a
, extracellular signal-regulated kinase-2
, extracellular regulated protein 2