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anti-Human GJA1 Antibodies:
anti-Rat (Rattus) GJA1 Antibodies:
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Chicken Monoclonal GJA1 Primary Antibody for IHC (f), IF - ABIN967718
Giepmans, Hengeveld, Postma, Moolenaar: Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. in The Journal of biological chemistry 2001
Show all 5 Pubmed References
Chicken Monoclonal GJA1 Primary Antibody for IHC (f), IF - ABIN967717
Loo, Berestecky, Kanemitsu, Lau: pp60src-mediated phosphorylation of connexin 43, a gap junction protein. in The Journal of biological chemistry 1995
Show all 5 Pubmed References
Human Polyclonal GJA1 Primary Antibody for IHC - ABIN965918
Solan, Fry, TenBroek, Lampe: Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation. in Journal of cell science 2003
Show all 4 Pubmed References
Human Polyclonal GJA1 Primary Antibody for IHC (p), WB - ABIN388369
Li, Zhang, Jiao, Zou: Knockdown of microRNA-181 by lentivirus mediated siRNA expression vector decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction. in Microvascular research 2009
Show all 9 Pubmed References
Human Polyclonal GJA1 Primary Antibody for ICC, IHC (fro) - ABIN5518645
Peng, Dai, Ji, Dai: The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol. in European journal of pharmacology 2010
Show all 3 Pubmed References
Human Polyclonal GJA1 Primary Antibody for IHC (p), WB - ABIN3043758
Li, Tang, Liang, Li, Wang, Song, Zheng, Xi, Zhang, Hescheler, Zhu: Coculture of embryonic ventricular myocytes and mouse embryonic stem cell enhance intercellular signaling by upregulation of connexin43. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2013
Show all 3 Pubmed References
Human GJA1 Primary Antibody for IHC - ABIN965917
Matsushita, Kurihara, Watanabe, Okada, Sakai, Amano: Alterations of phosphorylation state of connexin 43 during hypoxia and reoxygenation are associated with cardiac function. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006
Show all 2 Pubmed References
Dog (Canine) Polyclonal GJA1 Primary Antibody for IF (p), IHC (p) - ABIN671451
Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014
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Chicken Polyclonal GJA1 Primary Antibody for WB - ABIN2473077
Donovan: Indomethacin, ketoprofen and corpus luteum regression in the guinea-pig. in British journal of pharmacology 1975
Show all 3 Pubmed References
Bird (Avian) Polyclonal GJA1 Primary Antibody for WB - ABIN152643
Sahin, Akdemir, Tuzcu, Sahin, Onderci, Ozercan, Ilhan, Kilic, Seren, Kucuk: Genistein suppresses spontaneous oviduct tumorigenesis in quail. in Nutrition and cancer 2010
The observations identify a novel strategy of prostate cancer cell diapedesis, which depends on the activation of intercellular Cx43/ERK1 (show MAPK3 Antibodies)/ERK2 (show MAPK1 Antibodies)/Cx43 signaling axis at the interfaces between Cx43-high prostate cancer and endothelial cells.
we present an overview of the key phosphatases known to interact with Cx43 or modulators of Cx43, as well as some possible therapeutic targets to regulate phosphatase activity in the heart.
many of the known non-canonical roles of Cx43 can be attributed to the recently identified six endogenous Cx43 truncated isoforms which are produced by internal translation. In general, alternative translation is a new leading edge for proteome expansion and therapeutic drug development.
Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics.
the complex regulatory and signalling networks controlled by the Cx43 CT, including the extensive protein interactome that underlies both gap junction channel-dependent and -independent functions.
Cx43 role in the regulation of the metastatic potential and migration of prostate cancer cells
Results showed that connexin 43 enhanced oxaliplatin cytotoxicity through gap junctional communication function and high concentration of oxaliplatin inhibited connexin 43 expression to counteract its cytotoxicity
Connexin 43 expression was significantly reduced or lost in prostate cancer tissues, which was associated with advanced clinicopathological features and poor biochemical recurrence-free survival of patients after radical prostatectomy
To match the stimulatory effect on acid uptake, cell-to-cell coupling in NHDF-Ad and CCD (show RUNX2 Antibodies)-112-CoN (show DISP1 Antibodies) cells was strengthened with TGFbeta1 (show TGFB1 Antibodies).Importantly, the activities of stromal AE2 (show SLC4A2 Antibodies) and connexin-43 do not place an energetic burden on cancer cells, allowing resources to be diverted for other activities
Study highlights the role of polyamines in the regulation of connexin 43 (Cx43) gap junctions. The study found that polyamines augment cell-to-cell communication and prevent uncoupling of Cx43 gap junctions induced by acidification and high [Ca2 (show CA2 Antibodies)+]i.
The ELF (show SPTBN1 Antibodies)-EMFs did not affect C2C12 myoblast viability or proliferation rate. Conversely, at ELF (show SPTBN1 Antibodies)-EMF intensity in the mT range, the myogenic process was accelerated, through increased expression of MyoD (show MYOD1 Antibodies), myogenin (show MYOG Antibodies), and connexin 43
These findings suggest that the proteolytic cleavage of the CTD under pathological conditions, such as under the activation of metalloproteinases during tissue injury or inflammation, may account for the deleterious effects of Cx43 in cartilage and bone disorders such as osteoarthritis.
Neonatal hypothyroidism affects germ cell survival and proliferation in prepubertal P mice via impaired testicular glucose homeostasis and decreased expression of connexin 43.
Cdk5 (show CDK5 Antibodies) directly phosphorylates Cx43, which regulates the membrane localization and degradation of Cx43 in neurons.
In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost (show SOST Antibodies)-/-mice, but revealed no cortical abnormalities in single Gja1+/-or Sost (show SOST Antibodies)+/-mice
the presence of the C-terminal domain of Cx43 in osteocytes and other cell types is important to maintain normal structure and mechanical integrity of bone.
The astroglial targeted connexin43 gene knocking-out in APPswe/PS1dE9 mice allowed to diminish gliotransmitter release and to alleviate neuronal damages, reducing oxidative stress and neuritic dystrophies in hippocampal neurons associated to plaques.
Thus we propose that Cx43 might enhance the activation of Nrf2 (show NFE2L2 Antibodies)/ARE pathway by means of inhibiting c-Src (show SRC Antibodies) activity to hinder the nuclear export of Nrf2 (show NFE2L2 Antibodies), and then reduce expression of FN, ICAM-1 (show ICAM1 Antibodies) and TGF-b1, ultimately attenuating renal fibrosis in diabetes.
Upon the induction of autophagy by dexamethasone (Dex), connexin 43 (Cx43) was internalized into autophagosome/autolysosomes and degraded by autophagy.
Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging.
Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.
serpinh1b is molecularly and functionally downstream of cx43. The gene serpinh1b codes for a protein called Hsp47, a molecular chaperone (show HSP90AA1 Antibodies) responsible for proper folding of procollagen molecules.
Hapln1a (show HAPLN1 Antibodies)-ECM (show MMRN1 Antibodies) stabilizes the secreted growth factor (show WNT2 Antibodies) Semaphorin3d (Sema3d (show SEMA3D Antibodies)), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.
Hapln1a (show HAPLN1 Antibodies) has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton
Sema3d (show SEMA3D Antibodies) functions in a common molecular pathway with Cx43 cell proliferation and joint formation
Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL (show COL6A1 Antibodies)) exhibited osteogenic characteristics, in which Cx43 played an important role.
Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.
Data demonstrate a cross-talk between IGF-1R (show IGF1R Antibodies) and AT-1R in AT-II and IGF-1 (show IGF1 Antibodies)-induced Cx43 expression in SV SMCs involving Erk 1 (show MAPK3 Antibodies)/2 and downstream activation of the AP-1 (show JUN Antibodies) transcription factor.
Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45 (show GJC1 Antibodies).
Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.
This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.
Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.
RhoA (show RHOA Antibodies) appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress
Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.
Human TGF-beta1 (show TGFB1 Antibodies) induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells
Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.
intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (show GJB2 Antibodies), Cx32 (show GJB1 Antibodies), and Cx43
CBN (show CALB1 Antibodies) blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.
Results describe the effect of suppression of connexin 43 and E-cadherin (show CDH1 Antibodies) on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
These findings indicated that Cx43/miR (show MYLIP Antibodies)-206 is involved in the pathogenesis of early stage steroid-induced avascular necrosis of the femoral head.
Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.
Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.
In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart
The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.
CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.
Data show that connexin 43 (Cx43) is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.
The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.
we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.
The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 (show CDK4 Antibodies) gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.
Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.
Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.
These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.
Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.
Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.
During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.
, gap junction 43 kDa heart protein
, gap junction alpha-1 protein
, gap junction membrane channel protein alpha 1
, connexin 32
, gap junction beta-1 protein
, gap junction membrane channel protein beta 1
, alpha 1 connexin
, gap junction protein, alpha 1
, short fin protein
, gap junction protein, alpha 1, 43 kD (connexin 43)
, vascular smooth muscle connexin-43
, alpha 1 gap junction protein
, gap junction protein, alpha 1, 43kDa (connexin 43)
, gap junction protein alpha 1
, alpha 3 connexin
, gap junction alpha-3 protein
, gap junction membrane channel protein alpha 3