Protein Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Alternative names and synonyms associated with MAP2K2

• mitogen-activated protein kinase kinase 2 (MAP2K2) antibody
• mitogen-activated protein kinase kinase 2 (Map2k2) antibody
• mitogen activated protein kinase kinase 2 (Map2k2) antibody
• MAP kinase kinase 2 (MKK2) antibody
• mitogen-activated protein kinase kinase 2b (map2k2b) antibody

• AA589381 antibody
• ATMKK2 antibody
• CFC4 antibody
• F27B13.50 antibody
• F27B13_50 antibody
• Show all synonym aliases
• MAP KINASE KINASE 1 antibody
• MAP kinase kinase 2 antibody
• MAPKK2 antibody
• MEK2 antibody
• MK1 antibody
• MK2 antibody
• MKK2 antibody
• Prkmk2 antibody
• zgc:172250 antibody

Protein level used designations for MAP2K2

ERK activator kinase 2 , MAP kinase kinase 2 , MAPK/ERK kinase 2 , dual specificity mitogen-activated protein kinase kinase 2 , mitogen-activated protein kinase kinase 2, p45 , MAP kinase/Erk kinase , MAPKK 2 , MEK 2 , mitogen activated protein kinase kinase 2 , protein kinase, mitogen activated, kinase 2, p45 , MEK2 , mitogen-activated protein kinase kinase type 2 , dual specificity mitogen activated protein kinase kinase 2