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There are no other biomarkers correlated with treatment responses following MEK1 (show MAP2K1 ELISA Kits)/2 inhibition.
MEK2 was essential for the phosphorylation of MKK3 (show MAP2K3 ELISA Kits)/MKK6 (show MAP2K6 ELISA Kits) and p38 MAPK (show MAPK14 ELISA Kits) that directly impacted on cyclin D1 (show CCND1 ELISA Kits) expression.
High MEK2 expression is associated with inflammation.
there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (show ICAM1 ELISA Kits)), ezrin (EZR (show EZR ELISA Kits)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase (show NOS ELISA Kits) 3 (NOS3) gene expressions in metabolic syndrome patients.
The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (show PTPN11 ELISA Kits)) syndrome
Data show that mitogen-activated protein kinase (show MAPK1 ELISA Kits) kinases MEK1 (show MAP2K1 ELISA Kits)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.
the purpose of this paper was to investigate MAPK (show MAPK1 ELISA Kits) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.
at clinically relevant concentrations, cDDP binds to and inhibits MEK1 (show MAP2K1 ELISA Kits)/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1 (show MAP2K1 ELISA Kits)/2
Endocytosis separates EGF (show EGF ELISA Kits) receptors from endogenous fluorescently labeled HRas (show HRAS ELISA Kits) and diminishes receptor signaling to MAP kinases in endosomes.
MEK1 (show MAP2K1 ELISA Kits) levels are upregulated at transcriptional level whereas MEK2 levels are downregulated at posttranslational level.
data suggest that, although short-term suppression of Mek1 (show MAP2K1 ELISA Kits)/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential
Erk5 (show MAPK7 ELISA Kits) MAP kinase (show MAPK1 ELISA Kits) is activated in response to PDGF (show PDGFA ELISA Kits)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (show MAP3K2 ELISA Kits), Mek1 (show MAP2K1 ELISA Kits)/2, Mek5 (show MAP2K5 ELISA Kits), PI3-kinase (show PIK3CA ELISA Kits) and protein kinase C (PKC (show PKC ELISA Kits)).
fluid shear stress induces autocrine TGF-beta (show TGFB1 ELISA Kits)/ALK5 (show TGFBR1 ELISA Kits)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (show MAP2K1 ELISA Kits)/2-mediated signaling.
FGF2 (show FGF2 ELISA Kits) is an extracellular inducer of COUP-TFII (show NR2F2 ELISA Kits) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (show NR2F2 ELISA Kits) expression prior to the onset of osteogenic differentiation
REDD1 (show DDIT4 ELISA Kits) is required for normal insulin (show INS ELISA Kits)-stimulated signaling, and a subtle balance exists between MEK1 (show MAP2K1 ELISA Kits)/2, REDD1 (show DDIT4 ELISA Kits), and mTOR (show FRAP1 ELISA Kits)
MEK1 (show MAP2K1 ELISA Kits) and MEK2 can substitute for each other but a minimum amount of MEK (show MDK ELISA Kits) is critical for placenta development and embryo survival
MK2 (show KCNA2 ELISA Kits)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.
MK2 (show KCNA2 ELISA Kits) attenuates dendritic cell-mediated Th1 (show HAND1 ELISA Kits) differentiation and autoimmune encephalomyelitis.
analysis of p38 (show CRK ELISA Kits)-MK2 (show KCNA2 ELISA Kits)-activated Rsk (show RPS6KA1 ELISA Kits) signaling in toll (show TLR4 ELISA Kits)-like receptor-stimulated dendritic cells
both MEK1 (show MAP2K1 ELISA Kits) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract
the AtMKK2-AtMPK10 (show MAPK10 ELISA Kits) MAPK (show MAPK1 ELISA Kits) module regulates leaf venation complexity by altering polar auxin transport efficiency
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (show MAPK4 ELISA Kits) activation concomitantly with MEKK1 (show MAP3K1 ELISA Kits) and MKK2 phosphorylation.
Ca(2 (show CA2 ELISA Kits)+) signaling occurred upstream of the MEKK1 (show MAP3K1 ELISA Kits)-MKK2 pathway. MEKK1 (show MAP3K1 ELISA Kits) was phosphorylated by calcium/calmodulin-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (show MAP3K1 ELISA Kits).
Data indicate that MEKK2 (show MAP3K2 ELISA Kits) is required for the mekk1 (show MAP3K1 ELISA Kits), mkk1 (show MAP2K1 ELISA Kits) mkk2, and mpk4 (show MAPK4 ELISA Kits) autoimmune phenotypes.
Data suggest that the MEKK1 (show MAP3K1 ELISA Kits)-MKK1 (show MAP2K1 ELISA Kits)/MKK2-MPK4 (show MAPK4 ELISA Kits) kinase cascade negatively regulates MEKK2 (show MAP3K2 ELISA Kits) and activation of MEKK2 (show MAP3K2 ELISA Kits) triggers SUMM2-mediated immune responses.
Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.
double loss-of-function mutant (mkk1 (show MAP2K1 ELISA Kits)/2) of MKK1 (show MAP2K1 ELISA Kits) and MKK2 is shown to have marked phenotypes in development and disease
Activation of MPK4 (show MAPK4 ELISA Kits) by flg22 is impaired in the mkk1 (show MAP2K1 ELISA Kits) mkk2 double mutants, suggesting that MKK1 (show MAP2K1 ELISA Kits) and MKK2 function together with MPK4 (show MAPK4 ELISA Kits) and MEKK1 (show MAP3K1 ELISA Kits) in a MAP kinase (show MAPK1 ELISA Kits) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
ERK activator kinase 2
, MAP kinase kinase 2
, MAPK/ERK kinase 2
, MAPKK 2
, MEK 2
, dual specificity mitogen-activated protein kinase kinase 2
, mitogen-activated protein kinase kinase 2, p45
, MAP kinase/Erk kinase
, mitogen activated protein kinase kinase 2
, protein kinase, mitogen activated, kinase 2, p45
, dual specificity mitogen activated protein kinase kinase 2
, mitogen-activated protein kinase kinase type 2