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AtMKK6-AtMPK13 module positively regulates lateral root formation.[AtMPK13]
p38delta promotes micro-aggregate transport by phosphorylating SQSTM1, a major scaffold protein that assembles soluble ubiquitylated proteins into micro-aggregates.
Study identified p38alpha and p38delta as critical regulators of ASC oligomerization, inflammasome activation, and IL-1beta secretion in keratinocytes. Furthermore, data suggest that the nature of the mitogen-activated protein kinase regulating inflammasome activity exhibits a certain cell specificity, with p38 playing a predominant role in keratinocytes and Jun N-terminal kinase 1 in cells of myeloid origin.
These observations indicate that p38alpha probably blocks brown adipose tissue thermogenesis through p38delta inhibition.
Mitogen-activated protein kinases p38gamma/p38delta deficiency protects against Candida albicans infection by increasing reactive oxygen species and iNOS enzyme production and thus the antifungal capacity of neutrophils and macrophages.
The knockdown of MAPK13 also blocked the effect of miR23a5p in osteogenic differentiation of bone marrow-derived mesenchymal stem cells.
expression of claudin-11 in cutaneous squamous cell carcinoma cells depended on the activity of p38delta MAPK
Study proposes MAPK p38delta protein as a key factor in breast cancer.
The p38delta mitogen-activated protein kinase was identified as a novel regulator of NLRP3 inflammasome activation in primary human macrophages, and thus, represents a potential target for modulation of atherosclerotic inflammation.
p38delta expression was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. No significant association was found for p38delta between its expression and other clinicopathological parameters. In Eca109 cells, p38delta can promote the cell growth and motility. p38delta overexpression promotes tumorigenesis in nude mice when p38delta was stably over-expressed and p38ga...
MAPK13 gene knockdown using siRNA reduced the aldehyde dehydrogenase high cell population and abrogated the tumor-initiating ability.
p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy
MAPK13 undergoes a larger interlobe configurational rearrangement upon activation compared with MAPK14.
PKCdelta activates a MEKK1/MEK3/p38delta MAPK cascade to increase p53 levels and p53 drives p21(Cip1) gene expression.
esophageal squamous cell carcinoma cell lines which are p38delta-negative grew more quickly than cell lines which express endogenous p38delta.
DNA methylation alterations are widespread in melanoma; epigenetic silencing of MAPK13 contributes to melanoma progression
Data indicate that p38delta mediates oncogene-induced senescence through a p53- and p16(INK4A)-independent mechanism.
GSK3alpha, GSK3beta, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes.
MAPK13 is responsible for IL-13-driven mucus production in human airway epithelial cells.
SEPW1 silencing increases MKK4, which activates p38gamma, p38delta, and JNK2 to phosphorylate p53 on Ser-33 and cause a transient G(1) arrest.
PRMT5 inhibits the PKCdelta- or 12-O-tetradecanoylphorbol-13-acetate-dependent increase in human involucrin expression, and PRMT5 dimethylates proteins in the p38delta complex.
cell-specific p38delta targeting modifies susceptibility to chemical skin carcinogenesis in a context-, stage-, and sex-specific manner.
Results reveal that p38delta contributes both cell-autonomous and paracrine effects during the course of skin tumor formation.
p38gamma and p38delta control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation.
Together, our results establish that p38gamma and p38delta are central to colitis-associated colon cancer formation through regulation of hematopoietic cell response to injury, and validate p38gamma and p38kappa as potential targets for cancer therapy.
p38gamma and p38delta are crucial regulators of inflammatory joint destruction in collagen-induced arthritis.
p27 inhibition of COX-2 expression was specifically due to phosphorylation of transcription factor cAMP response element binding (CREB) phosphorylation mediated by p38beta and p38delta.
Aberrant p38delta-PKD1 signaling in neutrophils may underlie development of acute lung injury and life-threatening acute respiratory distress syndrome.
p38gamma and p38delta kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation
results indicate that p38gamma and p38delta have a role in the suppression of tumor development
Demonstrate roles of the p38alpha/beta/delta isoforms in the regulation of 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation.
Overexpression of the type II transforming growth factor-beta receptor inhibits fibroblasts proliferation and activates extracellular signal regulated kinase and c-Jun N-terminal kinase
MKK3 activation is required for subsequent p38alpha and p38delta MAPK activation and collagen stimulation by TGF-beta1
p38 has a role in mediating induction of VEGF mRNA expression by sodium arsenite
data suggest role for mitogen-activated protein kinase (MAPK) kinase 3 (MKK3)-p38alpha and p38delta MAPK pathway in mediating vascular endothelial growth factor VEGF164 isoform-specific stimulation by transforming growth factor-beta1 in mesangial cells
sapk4 activation mediates apoptosis and neurodegeneration in infantile neuronal ceroid lipofuscinosis
This study constitutes the first analysis addressing the functionality of p38beta, p38gamma and p38delta in satellite cell-dependent adult muscle regeneration and growth.
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene.
MAP kinase 13
, MAPK 13
, MAP kinase p38 delta
, mitogen-activated protein kinase p38 delta
, stress-activated protein kinase 4
, SAPK/Erk/kinase 4
, mitogen activated protein kinase 13
, p38 delta MAP kinase
, mitogen-activated protein kinase 13