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AtMKK6-AtMPK13 module positively regulates lateral root formation.[AtMPK13]
Study proposes MAPK p38delta protein as a key factor in breast cancer.
The p38delta mitogen-activated protein kinase (show MAPK1 Proteins) was identified as a novel regulator of NLRP3 (show NLRP3 Proteins) inflammasome activation in primary human macrophages, and thus, represents a potential target for modulation of atherosclerotic inflammation.
p38delta expression was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. No significant association was found for p38delta between its expression and other clinicopathological parameters. In Eca109 cells, p38delta can promote the cell growth and motility. p38delta overexpression promotes tumorigenesis in nude mice when p38delta was stably over-expressed and p38ga...
MAPK13 gene knockdown using siRNA reduced the aldehyde dehydrogenase high cell population and abrogated the tumor-initiating ability.
p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy
MAPK13 undergoes a larger interlobe configurational rearrangement upon activation compared with MAPK14 (show MAPK14 Proteins).
PKCdelta (show PKCd Proteins) activates a MEKK1 (show MAP3K1 Proteins)/MEK3 (show MAP2K3 Proteins)/p38delta MAPK (show MAPK1 Proteins) cascade to increase p53 (show TP53 Proteins) levels and p53 (show TP53 Proteins) drives p21(Cip1 (show CDKN1A Proteins)) gene expression.
esophageal squamous cell carcinoma cell lines which are p38delta-negative grew more quickly than cell lines which express endogenous p38delta.
DNA methylation alterations are widespread in melanoma; epigenetic silencing of MAPK13 contributes to melanoma progression
Data indicate that p38delta mediates oncogene-induced senescence through a p53- and p16(INK4A)-independent mechanism.
Results reveal that p38delta contributes both cell-autonomous and paracrine effects during the course of skin tumor formation.
p38gamma (show MAPK12 Proteins) and p38delta control heart growth by modulating mTOR (show FRAP1 Proteins) pathway through DEPTOR (show DEPTOR Proteins) phosphorylation and subsequent degradation.
Together, our results establish that p38gamma (show MAPK12 Proteins) and p38delta are central to colitis-associated colon cancer formation through regulation of hematopoietic cell response to injury, and validate p38gamma (show MAPK12 Proteins) and p38kappa as potential targets for cancer therapy.
p38gamma and p38delta are crucial regulators of inflammatory joint destruction in collagen-induced arthritis.
GSK3alpha, GSK3beta, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes.
p27 inhibition of COX-2 expression was specifically due to phosphorylation of transcription factor cAMP response element binding (CREB) phosphorylation mediated by p38beta and p38delta.
Aberrant p38delta-PKD1 (show PKD1 Proteins) signaling in neutrophils may underlie development of acute lung injury and life-threatening acute respiratory distress syndrome.
p38gamma (show MAPK12 Proteins) and p38delta kinases regulate the Toll-like receptor 4 (TLR4 (show TLR4 Proteins))-induced cytokine production by controlling ERK1/2 protein kinase (show CDK7 Proteins) pathway activation
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene.
MAP kinase 13
, MAPK 13
, MAP kinase p38 delta
, mitogen-activated protein kinase p38 delta
, stress-activated protein kinase 4
, SAPK/Erk/kinase 4
, mitogen activated protein kinase 13
, p38 delta MAP kinase
, mitogen-activated protein kinase 13