Browse our anti-MAPK4 (MAPK4) Antibodies

Human Mitogen-Activated Protein Kinase 4 (MAPK4) interaction partners

1. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.

2. Data defined a novel MK5 interaction motif (FRIEDE) within both ERK4 and ERK3 that is essential for binding to the C-terminal region of MK5.

3. Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5. Interaction of ERK4 with MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3.

Mouse (Murine) Mitogen-Activated Protein Kinase 4 (MAPK4) interaction partners

1. Results uncover a unique role for ERK3, dependent on its kinase activity, during T cell development and show that this atypical MAPK is essential to sustain CD4(+) CD8(+) (DP) thymocytes survival during RAG-mediated rearrangements.

2. The atypical MAPK ERK3 is a new and important regulator of T cell receptor-induced T cell activation.

3. Data suggest that ERK3 is crucial for spindle stability and required for the metaphase-anaphase transition in mouse oocyte maturation.

4. Data suggest that Erk4 is dispensable for mouse embryonic development and reveals that Erk3 and Erk4 have acquired specialized functions through evolutionary diversification.

5. a critical role for Erk3 in the establishment of fetal growth potential and pulmonary function in the mouse

6. Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5. Interaction of ERK4 with MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3.

Arabidopsis thaliana Mitogen-Activated Protein Kinase 4 (MAPK4) interaction partners

1. H2S inhibited the opening of stomata under cold stress, which required the participation of MPK4. In conclusion, MPK4 is a downstream component of H2S-related cold-stress resistance, and H2S and MPK4 both regulated the cold response genes and stomatal movement to response the cold stress.

2. Proteome changes associated with MPK4 and MPK6 deficiency in Arabidopsis roots.

3. AvrRpt2 specifically blocks the flagellin-induced activation of MPK4.

4. Data show that MPK4 phosphorylation of MYB75 increases its stability and is essential for light-induced anthocyanin accumulation. Our findings reveal an important role for a MAPK pathway in light signal transduction.

5. ASR3 functions as a transcriptional repressor regulated by microbe-associated molecular patterns-activated MPK4 to fine-tune plant immune gene expression.

6. Mitogen-activated protein kinase 4 is a salicylic acid-independent regulator of growth but not of photosynthesis in Arabidopsis

7. Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 activation concomitantly with MEKK1 and MKK2 phosphorylation.

8. Data indicate that MEKK2 is required for the mekk1, mkk1 mkk2, and mpk4 autoimmune phenotypes.

9. Arabidopsis MPK4 can interact with and be phosphorylated by the cytokinesis-related MAP kinase kinase, AtMKK6.

10. MPK4 activity was found to compromise effector-triggered immunity conditioned by the Toll Interleukin-1 Receptor-nucleotide binding (NB)-Leu-rich repeat (LRR) receptors RPS4 and RPP4 but not by the coiled coil-NB-LRR receptors RPM1 and RPS2.

11. Data suggest that the MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates MEKK2 and activation of MEKK2 triggers SUMM2-mediated immune responses.

12. Findings show that seedling survival of prolonged oxygen deprivation was improved in transgenics that ectopically overexpress MPK3, MPK4 and MPK6.

13. MKS1 function and subcellular location requires an intact N-terminus important for both MPK4 and WRKY33 interactions

14. MPK4 is shown to be involved in the regulation of mitosis/cytokinesis through modulation of the cell division plane and cytokinetic progression.

15. These results indicate that MPK4 is the downstream target of MKK6/ANQ in the regulation of cytokinesis in Arabidopsis and that MPK11 is also involved in cytokinesis.

16. ANP2/ANP3, MPK4, and the MT-associated protein MAP65-1 are involved in microtubule-dependent cell growth mechanisms.

17. Pseudomonas syringae effector protein AvrB interacts with Arabidopsis MPK4 and the HSP90 chaperone, and AvrB induces MPK4 activation in a manner promoted by HSP90

18. The susceptibility of A. thaliana plants to Alternaria brassicicola that induces defensive pathways via EDS1 and PAD4 is reported.

19. MEKK1 is essential for activation of MPK4 and negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are dependent on both RAR1 (resistance protein function) and SID2 (isochorismate synthase)

20. This study demonstrated that analysis of plants carrying T-DNA knockout alleles indicated that MEKK1 is required for flg22-induced activation of MPK4.