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anti-Human MAPK6 Antibodies:
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Rat (Rattus) Monoclonal MAPK6 Primary Antibody for BI, IF - ABIN967749
Clark, Hynes: Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. in The Journal of biological chemistry 1996
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Human Monoclonal MAPK6 Primary Antibody for FACS, ELISA - ABIN966092
Déléris, Rousseau, Coulombe, Rodier, Tanguay, Meloche: Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. in Journal of cellular physiology 2008
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Human Monoclonal MAPK6 Primary Antibody for FACS, ELISA - ABIN969115
Klinger, Turgeon, Lévesque, Wood, Aagaard-Tillery, Meloche: Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. in Proceedings of the National Academy of Sciences of the United States of America 2009
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Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK (show PRKAA1 Antibodies)/p38 MAPK (show MAPK14 Antibodies)-ERK3 (show MAPK4 Antibodies)/mTORC1 pathways. ERK3 (show MAPK4 Antibodies) is a newfound potential prognostic predictor and a tumor suppressor in ICC.
Study revealed a post-translational regulation of TDP2 (show TDP2 Antibodies) activity and discovered a new role of ERK3 (show MAPK4 Antibodies) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (show TOP2A Antibodies) inhibitors.
MAPK6 could rescue the cell growth induced by miR499a and HBV
ERK3 (show MAPK4 Antibodies) regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3 (show NCOA3 Antibodies)/SP-1 (show PSG1 Antibodies)-mediated VEGFR2 (show KDR Antibodies) expression.
These findings further expand distinct roles of cyclin D3 (show CCND3 Antibodies) and suggest the potential activity of ERK3 (show MAPK4 Antibodies) in cell proliferation.
Cdc14A (show CDC14A Antibodies) forms a stable complex with atypical mitogen-activated protein kinase (show MAPK1 Antibodies) Erk3 (show MAPK4 Antibodies) in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain.
identify the Erk3 (show MAPK4 Antibodies) protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK (show MAPK1 Antibodies) signaling.
A previously unknown role for ERK3 (show MAPK4 Antibodies) in promoting lung cancer cell invasiveness by phosphorylating SRC-3 (show NCOA3 Antibodies) and regulating SRC-3 (show NCOA3 Antibodies) proinvasive activity by site-specific phosphorylation.
ERK3 (show MAPK4 Antibodies) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 (show CDKN1A Antibodies) but not that of substrates ubiquitinated on internal lysine residues.
ERK3 (show RYK Antibodies) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular-regulated kinase 3 (ERK3 (show RYK Antibodies)) specifically interacts with the MAPK-activated protein kinase 5 (MK5 (show MAPKAPK5 Antibodies) or PRAK (show MAPKAPK5 Antibodies)) in vitro and in vivo.
Results demonstrate a specific interaction between extracellular signal-regulated kinase 3 (ERK3) and mitogen-activated protein kinase-activated protein kinase-5 (MK5 (show MAPKAPK5 Antibodies)).
p38gamma (show MAPK12 Antibodies) MAP kinase (show MAPK1 Antibodies) (SAPK3/p38gamma (show MAPK12 Antibodies)) was shown to catalyse phosphorylation of SAP97 (show DLG1 Antibodies).
Results show that Cdo (show CDO1 Antibodies) is important for full Abl kinase activity, and Abl (show ABL1 Antibodies) is necessary for full activation of p38 MAPK (show MAPK14 Antibodies), during myogenic differentiation.
Results suggest that these mutants can be used to analyze the specific biological functions of MAP kinase 6 (MPK6).
These data highlight MPK6 and MKP1 (show DUSP1 Antibodies) as components of an L-Glutamate (show GRIN2A Antibodies) pathway linking the auxin response, and cell division for primary root growth.
Genetic and biochemical evidences not only show that MEK1 (show MAP2K1 Antibodies)-MPK6 cascade, AtRBOHD/F-dependent H2O2 and NIA1-dependent NO are all involved in dark-induced stomatal closure in Arabidopsis, also indicate that MEK1 (show MAP2K1 Antibodies)-MPK6 cascade functions via working downstream of H2O2 and upstream of NO.
that MPK3 (show MAPK3 Antibodies)/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF (show CEBPZ Antibodies) expression and freezing tolerance in plants
BASL polarization leads to elevated nuclear MPK6 signaling and lowered SPCH abundance in one of the two daughter cells. Therefore, two daughter cells are differentiated by BASL polarity-mediated differential suppression of SPCH, which may provide developmental plasticity in plant stem cell asymmetric cell division.
results indicated that AIK1-MKK5 (show MAP2K5 Antibodies)-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (show MAPK1 Antibodies) cascade.
MPK6 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3 (show MAPK3 Antibodies)/MPK6 cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
MPK6-mediated regulation of MYB15 plays an important role in cold stress signaling in Arabidopsis.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.
, MAP kinase 6
, MAP kinase isoform p97
, MAPK 6
, extracellular signal-regulated kinase 3
, extracellular signal-regulated kinase, p97
, protein kinase, mitogen-activated 5
, protein kinase, mitogen-activated 6
, Erk-3 related
, mitogen activated protein kinase 4
, mitogen activated protein kinase 6
, protein kinase, mitogen activated kinase 4
, extracellular related kinase 3
, mitogen-activated protein kinase 6