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Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK (show PRKAA1 Proteins)/p38 MAPK (show MAPK14 Proteins)-ERK3 (show MAPK4 Proteins)/mTORC1 pathways. ERK3 (show MAPK4 Proteins) is a newfound potential prognostic predictor and a tumor suppressor in ICC.
Study revealed a post-translational regulation of TDP2 (show TDP2 Proteins) activity and discovered a new role of ERK3 (show MAPK4 Proteins) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (show TOP2A Proteins) inhibitors.
MAPK6 could rescue the cell growth induced by miR499a and HBV
ERK3 (show MAPK4 Proteins) regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3 (show NCOA3 Proteins)/SP-1 (show PSG1 Proteins)-mediated VEGFR2 (show KDR Proteins) expression.
These findings further expand distinct roles of cyclin D3 (show CCND3 Proteins) and suggest the potential activity of ERK3 (show MAPK4 Proteins) in cell proliferation.
Cdc14A (show CDC14A Proteins) forms a stable complex with atypical mitogen-activated protein kinase (show MAPK1 Proteins) Erk3 (show MAPK4 Proteins) in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain.
identify the Erk3 (show MAPK4 Proteins) protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK (show MAPK1 Proteins) signaling.
A previously unknown role for ERK3 (show MAPK4 Proteins) in promoting lung cancer cell invasiveness by phosphorylating SRC-3 (show NCOA3 Proteins) and regulating SRC-3 (show NCOA3 Proteins) proinvasive activity by site-specific phosphorylation.
ERK3 (show MAPK4 Proteins) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 (show CDKN1A Proteins) but not that of substrates ubiquitinated on internal lysine residues.
ERK3 (show RYK Proteins) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular-regulated kinase 3 (ERK3 (show RYK Proteins)) specifically interacts with the MAPK-activated protein kinase 5 (MK5 (show MAPKAPK5 Proteins) or PRAK (show MAPKAPK5 Proteins)) in vitro and in vivo.
Results demonstrate a specific interaction between extracellular signal-regulated kinase 3 (ERK3) and mitogen-activated protein kinase-activated protein kinase-5 (MK5 (show MAPKAPK5 Proteins)).
p38gamma (show MAPK12 Proteins) MAP kinase (show MAPK1 Proteins) (SAPK3/p38gamma (show MAPK12 Proteins)) was shown to catalyse phosphorylation of SAP97 (show DLG1 Proteins).
Results show that Cdo (show CDO1 Proteins) is important for full Abl kinase activity, and Abl (show ABL1 Proteins) is necessary for full activation of p38 MAPK (show MAPK14 Proteins), during myogenic differentiation.
Genetic and biochemical evidences not only show that MEK1 (show MAP2K1 Proteins)-MPK6 cascade, AtRBOHD/F-dependent H2O2 and NIA1-dependent NO are all involved in dark-induced stomatal closure in Arabidopsis, also indicate that MEK1 (show MAP2K1 Proteins)-MPK6 cascade functions via working downstream of H2O2 and upstream of NO.
that MPK3/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF expression and freezing tolerance in plants
BASL polarization leads to elevated nuclear MPK6 signaling and lowered SPCH abundance in one of the two daughter cells. Therefore, two daughter cells are differentiated by BASL polarity-mediated differential suppression of SPCH, which may provide developmental plasticity in plant stem cell asymmetric cell division.
results indicated that AIK1-MKK5 (show MAP2K5 Proteins)-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (show MAPK1 Proteins) cascade.
MPK6 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3 (show MAPK3 Proteins)/MPK6 cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
MPK6-mediated regulation of MYB15 plays an important role in cold stress signaling in Arabidopsis.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 (show MAPK3 Proteins) and MPK6 can both interact with SPOROCYTELESS/NOZZLE (SPL (show SGPL1 Proteins)) in vitro and in vivo and can phosphorylate the SPL (show SGPL1 Proteins) protein in vitro.
AIK1-MKK5 (show MAP2K5 Proteins)-MPK6 cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.
, MAP kinase 6
, MAP kinase isoform p97
, MAPK 6
, extracellular signal-regulated kinase 3
, extracellular signal-regulated kinase, p97
, protein kinase, mitogen-activated 5
, protein kinase, mitogen-activated 6
, Erk-3 related
, mitogen activated protein kinase 4
, mitogen activated protein kinase 6
, protein kinase, mitogen activated kinase 4
, extracellular related kinase 3
, mitogen-activated protein kinase 6