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High ERK5 expression is associated with malignant pleural mesothelioma.
Small interfering RNA knockdown of MAPK7 demonstrated that MAPK7 regulates a subset of WNK1 (show WNK1 Proteins)-regulated genes and controls the migration and cell proliferation
The data suggest that miR (show MLXIP Proteins)-143 might represent a novel genetic element to enhance production of difficult-to-express proteins in CHO (show COL11A1 Proteins) cells which may be partly mediated by down-regulation of MAPK7.
our findings suggest that rare coding variants in MAPK7 predispose to AIS (show AR Proteins), providing clues to understanding the mechanisms of AIS (show AR Proteins).
ERK5 associates with CKII (show CSNK2A1 Proteins) to play essential roles in GPIb-IX-mediated platelet activation via the PTEN/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway.
For gain and loss of function studies, constitutively active MEK5 (show MAP2K5 Proteins) (CA-MEK5 (show MAP2K5 Proteins)) and ERK5 shRNA lentiviruses were used to activate or knock down extracellular signal-regulated kinase 5 (ERK5). Our results confirmed that low concentrations of H2O2 promoted HUVECs angiogenesis in vitro, and ERK5 is an essential mediator of this process. Therefore, ERK5 may be a potential therapeutic target for promoting angiogenesis
ERK5 expression was increased in 58% of cases and associated with the presence of metastasis and more advanced stages in clear cell renal cell carcinoma (show MOK Proteins) patients. ERK5 may be a new prognostic marker in this type of tumor.
FOXF1 (show FOXF1 Proteins) promotes prostate tumor growth and progression by activating ERK5 signaling
CCh induced TGF-beta1 (show TGFB1 Proteins) self-sustaining signaling loops by potentiating ERK5 signaling and promoted myofibroblast activity. This autocrine signaling mechanism may be an attractive therapeutic target to block the fibrotic response, which was modulated by the combination of glycopyrronium and indacaterol.
In the current study, five structures of the ERK5 kinase domain co-crystallized with ERK5 inhibitors are reported. Interestingly, three of the compounds bind at a novel allosteric binding site in ERK5, while the other two bind at the typical ATP-binding site.
the data revealed that puerarin inhibited the monocyte adhesion in vitro and in vivo and thus reduced atherosclerotic lesions in apoE (show APOE Proteins)-/- mice; the protective effects were mediated by activation of ERK5/KLF2 (show KLF2 Proteins) signaling pathway.
Extracellular-signal-regulated kinase 5 plays an essential role in the gestational augmentation of beta-cell proliferation.
This study was undertaken to explore the mechanism whereby ERK5 inhibition instigates pancreatic beta-cell apoptosis via an endoplasmic reticulum stress-dependent signaling pathway.
the present study demonstrated that ERK5 positively regulates TS-induced urocystic EMT (show ITK Proteins) in vivo. These findings indicate the important role of ERK5 in TS-associated carcinogenesis and provide a potential strategy for the search of a novel interventional target in TS-associated bladder tumorigenesis.
These findings define an antagonistic function of ATM (show ATM Proteins) and MAPK7 in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 inhibits thymic lymphoma growth in Atm (show ATM Proteins)-/- mice by partially restoring the DNA damage response in thymocytes.
Erk5 role in the cardiac mitochondria and the Pgc-1alpha regulation
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
Using compound selectivity engineering and CRISPR/Cas9 genome editing, distinct functions for Erk5 and Brd4 (show BRD4 Proteins) in pluripotency regulation of mouse embryonic stem cells have been revealed.
These results suggest that YAP (show YAP1 Proteins) promotes muscle differentiation by activating the Abl (show ABL1 Proteins)/Src (show SRC Proteins)/MEKK3 (show MAP3K3 Proteins)/MEK5 (show MAP2K5 Proteins)/ERK5 kinase cascade.
Data showed that expression of the MKK7 (show MAP2K7 Proteins) gene in wild-type plants is induced by pathogen infection. Reducing mRNA levels of MKK7 (show MAP2K7 Proteins) by antisense RNA expression not only compromises basal resistance, but also blocks the induction of SAR (show SRL Proteins).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
, BMK1 kinase
, MAP kinase 7
, MAPK 7
, big MAP kinase 1
, extracellular signal-regulated kinase 5
, extracellular-signal-regulated kinase 5
, extracellular signal regulated kinase 5
, mitogen activated protein kinase 7
, mitogen-activated kinase 7
, Big MAP kinase 1
, Extracellular signal-regulated kinase 5
, LOW QUALITY PROTEIN: mitogen-activated protein kinase 7
, bmk I
, mitogen-activated protein kinase 7 L homeolog