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Jnk2-deficient mice were more likely to develop features of glaucomatous neurodegeneration than DBA/2J mice expressing Jnk2.
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these pathological and molecular changes induced by diabetes were eliminated in JNK2(-/-) diabetic mice compared to JNK2(-/-) control mice, and C66 treatment did not further affect these parameters in JNK2(-/-) diabetic mice. Our results indicate that C66 ameliorates diabetic cardiomyopathy by inhibiting JNK2 relative pathways.
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the role of MAPK8/9 in autophagy may be context-dependent and more complex than previously considered.
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JNK2 activates CaMKII, a critical proarrhythmic molecule in cardiac muscle.
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JNK2 activation up-regulates CaMKIIdelta expression in the aged atrium and may promote the occurrence of cardiac arrhythmias.
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These data suggest that JNK2 signaling activation is necessary for the atherosclerosis and hypertension induced by vitamin D deficiency
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The up-regulation of HMGB1 was thought to be modified by dual channels: in the transcriptional level, it was regulated by JNK1/JNK2-ATF2 axis; post-transcriptionally, it was regulated by the microRNA (miR)-200 family, especially miR-429. miR-429 liver conditional knockout mice (miR-429(Deltahep)), fed either a normal diet or an HFD, showed severe liver inflammation and dysfunction, accompanied by greater expression of ...
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these results identify a protective role of epithelial JNK2 signaling to maintain mucosal barrier function, epithelial cell integrity, and mucus layer production in the event of inflammatory tissue damage
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The MAP kinase JNK2 mediates cigarette smoke-induced tissue factor activation, arterial thrombosis and reactive oxygen species production.
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activation of JNK in the endoplasmic reticulum stress response precedes activation of XBP1.
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JNK-2 regulates aggrecan degradation in cultured murine cartilage and surgically induced osteoarthritis in vivo following mechanical destabilization of the knee joint.
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activation of astrocyte MMP2/JNK1/2 contributes to the pathogenesis of pain hypersensitivity in the complex regional pain syndrome model
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JNK1/2-dependent regulation of p66ShcS36 phosphorylation, is reported.
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This study demonstrated that the disruption of JNK2 appears to have a greater impact on tolerance than the other isoforms in the tail-flick but not the hot-plate test.
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In hepatocytes, JNK1 and JNK2 appear to have combined effects in protecting from drug-induced liver injury.
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although JNK activation and RIP3 expression are induced by FS, neither contributes to the liver injury.
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morphine activated JNK2 through an arrestin-independent Src- and PKC-dependent mechanism, whereas fentanyl activated JNK2 through a Src-GRK3/arrestin-2-dependent and PKC-independent mechanism.
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studies herein support that JNK2 inhibits cell differentiation in normal and cancer-derived mammary cells
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Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release.
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gene deficient mice displayed defective mitophagy, which resulted in tissue damage under hypoxic stress, and increased sepsis