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anti-Mouse (Murine) MAPKAP Kinase 2 Antibodies:
anti-Human MAPKAP Kinase 2 Antibodies:
anti-Rat (Rattus) MAPKAP Kinase 2 Antibodies:
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Human Monoclonal MAPKAP Kinase 2 Primary Antibody for ICS - ABIN1177087
Ben-Levy, Leighton, Doza, Attwood, Morrice, Marshall, Cohen: Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. in The EMBO journal 1996
Show all 8 Pubmed References
Human Monoclonal MAPKAP Kinase 2 Primary Antibody for ICS - ABIN1177089
Clifton, Young, Cohen: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. in FEBS letters 1996
Show all 8 Pubmed References
Human Monoclonal MAPKAP Kinase 2 Primary Antibody for ICS - ABIN1177088
Engel, Kotlyarov, Gaestel: Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. in The EMBO journal 1998
Show all 7 Pubmed References
Cow (Bovine) Polyclonal MAPKAP Kinase 2 Primary Antibody for IF (p), IHC (p) - ABIN681523
Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012
Show all 2 Pubmed References
Human Polyclonal MAPKAP Kinase 2 Primary Antibody for DB, IHC (p) - ABIN389585
Xu, Zhou, Xiong, Zou, Deng, Ganaie, Kleiboeker, Peng, Liu, Wang, Ye, Qiu: Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway. in PLoS pathogens 2017
a p38 MAPKAPK2 kinase cascade modulates the activity of F-actin at the yolk cell margin circumference allowing the gradual closure of the blastopore as epiboly progresses
MK2 (show KCNA2 Antibodies) promotes polarization of tumor-associated macrophages into protumorigenic, proangiogenic M2-like macrophages.
Phosphorylation of inhibitory PAS domain protein (IPAS (show HIF3A Antibodies)) at Ser184 by MAPK-activated protein kinase 2 (MK2 or MAPKAPK2) enhances the proapoptotic function of IPAS (show HIF3A Antibodies).
MK2 (show KCNA2 Antibodies)-mediated RIPK1 (show RIPK1 Antibodies) phosphorylation is an important molecular mechanism limiting the sensitivity of the cells to the cytotoxic effects of TNF (show TNF Antibodies).
p38MAPK (show MAPK14 Antibodies)/MK2 (show KCNA2 Antibodies) phosphorylation of RIPK1 (show RIPK1 Antibodies) is a crucial checkpoint for cell fate in inflammation and infection that determines the outcome of bacteria-host cell interaction.
MK2 (show KCNA2 Antibodies)-mediated phosphorylation of RIPK1 (show RIPK1 Antibodies) serves as a checkpoint within the TNF (show TNF Antibodies) signaling pathway that integrates cell survival and cytokine production.
this study shows that the loss of MK2 (show KCNA2 Antibodies) in mast cells decreases the IL-33 (show IL33 Antibodies)-induced leukocyte recruitment and the resulting skin inflammation
MK2 (show KCNA2 Antibodies) signaling differentially regulated CCL3 (show CCL3 Antibodies) and CCL4 (show CCL4 Antibodies).
In silico analyses and experimental validation demonstrated that the kinase activity of p38(MAPK (show MAPK14 Antibodies)) determines signal amplitude, whereas phosphatase activity affects both signal amplitude and duration. p38(MAPK (show MAPK14 Antibodies)) and MK2 (show KCNA2 Antibodies) concentrations and responsiveness toward IL-1beta (show IL1B Antibodies) were quantitatively compared between hepatocytes and macrophages
MK2 (show KCNA2 Antibodies)-activating peptide (MK2 (show KCNA2 Antibodies)-AP) blocks the effects of anthrax lethal toxin on endothelial barriers in cultured cells and reduces pulmonary vascular leak in rats.
MK2 (show KCNA2 Antibodies) regulates postnatal arteriogenesis by controlling vascular recruitment of monocytes/macrophages in dual manner: regulation of endothelial MCP-1 (show CPT1B Antibodies) expression in response to hemodynamic and inflammatory forces as well as MCP-1 (show CPT1B Antibodies) dependent monocyte migration
The novel MK2 (show KCNA2 Antibodies) substrates have emerged in the DNA damage response, autophagy, and obesity, making MK2 (show KCNA2 Antibodies) a multifunctional kinase at the crossroads of stress response and cell death.
According to the information mentioned above, we now report the design and synthesis of some series of new urea derivatives that were then evaluated for their inhibitory activities against MAPKAPK2, TNF-a (show TNF Antibodies), and p38a (show MAPK14 Antibodies)
MK2 (show KCNA2 Antibodies) post-transcriptionally regulates TNF-alpha (show TNF Antibodies)-induced ICAM-1 (show ICAM1 Antibodies) expression by altering the cytoplasmic localization of HuR (show ELAVL1 Antibodies) in human lung microvascular endothelial cells.
MK2 (show KCNA2 Antibodies) overexpression is associated with primary liver tumors.
CEP131 (show AZI1 Antibodies) is the key regulatory target of MK2 (show KCNA2 Antibodies) and 14-3-3 (show YWHAQ Antibodies) in centriolar satellite remodeling.
mTOR (show FRAP1 Antibodies) controls the senescence-associated secretory phenotype by differentially regulating the translation of the MK2 (show KCNA2 Antibodies) (also known as MAPKAPK2).
analysis of signaling cooperation between p38-MAPK (show MAPK14 Antibodies)/MAPKAP-2/Hsp27 (show HSPB1 Antibodies) and intracellular calcium release in AA-induced HBEC apoptosis
findings reveal MK2 (show KCNA2 Antibodies)/MK3 (show KCNA3 Antibodies) as crucial stress-responsive kinases that promote autophagy through Beclin 1 (show BECN1 Antibodies) S90 phosphorylation
The protein expression of both HMGB1 (show HMGB1 Antibodies) and MAPKAPK2 were increased in KLM1-R cells.
Data indicate the binding mode and molecular mechanism of action of MAPK-activated protein kinase-2 (MK2) and inhibitors.
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
MAP kinase-activated protein kinase 2
, betty boop
, mitogen-activated protein kinase-activated protein kinase 2
, MAPK-activated protein kinase 2
, MAPKAP kinase 2
, map kinase activated protein kinase-2