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anti-Mouse (Murine) MAPKAP Kinase 5 Antibodies:
anti-Human MAPKAP Kinase 5 Antibodies:
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Human Monoclonal MAPKAP Kinase 5 Primary Antibody for IHC, ELISA - ABIN969362
Paliga, Natale, Watson: p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development. in Biology of the cell / under the auspices of the European Cell Biology Organization 2005
Show all 3 Pubmed References
Human Polyclonal MAPKAP Kinase 5 Primary Antibody for IHC (p), WB - ABIN389587
Daily, Monks, Leggas, Moscow: Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition. in Toxicon : official journal of the International Society on Toxinology 2010
Human Polyclonal MAPKAP Kinase 5 Primary Antibody for ICC, IF - ABIN4347179
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
MK5 is being discussed as a putative novel regulator of cardiac fibroblast function. (Review)
MK5 haplodeficiency attenuated the progression of hypertrophy, reduced collagen type 1 mRNA, and protected diastolic function in response to chronic pressure overload.
An alternative targeting strategy of MK5/PRAK (termed MK5/PRAK-Deltaex6) increased neither tumor incidence in the one step skin carcinogenesis model, nor Ras-induced transformation in primary cells.
MK5 positively regulates Rag transcription via phosphorylation of Foxo1 (show FOXO1 Antibodies) in developing B cells.
observations have demonstrated that PRAK is not required for either the rottlerin-mediated anti-chlamydial activity or rottlerin inhibition of sphingolipid trafficking, suggesting rottlerin may achieve its inhibitory role by targeting other host factors
Results suggest that PRAK may function as a tumor suppressor in multiple types of cancers.
the regulation of neuronal morphogenesis is proposed as the first physiological function of the ERK3 (show RYK Antibodies)/MK5 signaling module
It was shown that the tumor-suppressing and tumor-promoting functions of the p38 (show CRK Antibodies)-PRAK pathway are temporally and spatially separated during cancer development in vivo, relying on the stimulus, and the tissue type and the stage of cancer development.
Rheb (show RHEB Antibodies) inactivation by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
MK5 co-immunoprecipitated ERK3 (show RYK Antibodies), but not ERK4 (show MAPK4 Antibodies) or p38 alpha (show MAPK14 Antibodies), in control and hypertrophying hearts (MK5).
PRAK might be a potential therapeutic target of Alzheimer's disease involved in receptor for advanced glycation end products-mediated cell signaling induced by Abeta (show APP Antibodies)
Plasma MAPKAPK5 protein was found to positively associate with the 10-year change in paired associates learning assessment in asymptomatic older twins.
Data highlight that DJ-1 (show PARK7 Antibodies) is the downstream interacting target for PRAK, and in response to oxidative stress PRAK may exert a cytoprotective effect by facilitating DJ-1 (show PARK7 Antibodies) to sequester Daxx (show DAXX Antibodies) in the nucleus, thus preventing cell death.
Data indicate that the structurally most flexible regions during molecular dynamics (MD) simulations of the native mitogen-activated protein kinase (show MAPK1 Antibodies)-activated protein kinase (show CDK7 Antibodies) MK5 model were the loop regions.
Studies with specific phosphoantibodies indicate that MK5 phosphorylates Hsp40/DnaJB1 (show DNAJB1 Antibodies) in vivo at Ser (show SIGLEC1 Antibodies)-149 or/and Ser (show SIGLEC1 Antibodies)-151 and Ser (show SIGLEC1 Antibodies)-171 in the C-terminal domain of Hsp40/DnaJB1 (show DNAJB1 Antibodies).
study shows Tip60 (show KAT5 Antibodies) plays an essential role in oncogenic ras-induced senescence; revealed a cascade of posttranslational modifications involving p38 (show CRK Antibodies), Tip60 (show KAT5 Antibodies) and PRAK, 3 proteins essential for ras-induced senescence; these modifications are critical for prosenescent function of Tip60 (show KAT5 Antibodies) and PRAK
these results firstly demonstrate that MK5 is degraded in response to doxorubicin and negatively regulates doxorubicin-induced apoptosis, providing novel insights into the molecular mechanism of doxorubicin resistance in hepatoma cells.
IGF2BP1 promotes the velocity and directionality of tumor-derived cell migration by determining the cytoplasmic fate of two novel target mRNAs: MAPK4 and PTEN
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
mitogen-activated protein kinase-activated protein kinase 5
, MAP kinase-activated protein kinase 5
, MAP kinase-activated protein kinase 5-like
, MAPK-activated protein kinase 5
, MAPKAP kinase 5
, p38-regulated/activated protein kinase