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anti-Human MKNK1 Antibodies:
anti-Mouse (Murine) MKNK1 Antibodies:
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Human Polyclonal MKNK1 Primary Antibody for WB - ABIN2801944
Fukunaga, Hunter: MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. in The EMBO journal 1997
Show all 4 Pubmed References
High expression of MNK1 is frequent in HCC (show FAM126A Antibodies) tissues, which promotes tumor proliferation and invasion, and is correlated with a poor overall survival.
High MNK1 expression in epithelial ovarian cancer tissues indicates poor clinical outcomes
these data show that NDRG1 (show NDRG1 Antibodies) is regulated by the oncogenic MAP kinase (show MAPK1 Antibodies)-interacting kinase pathway, a target for cancer therapy
MKNK1 polymorphism was associated with treatment response in metastatic colorectal cancer.
Elevated levels of p-Mnk1, p-eIF4E (show EIF4E Antibodies) and p-p70S6K (show RPS6KB1 Antibodies) proteins are associated with tumor recurrence and poor prognosis in astrocytomas. Overexpression of p-eIF4E (show EIF4E Antibodies) and co-expression of p-Mnk1, p-eIF4E (show EIF4E Antibodies) and p-p70S6K (show RPS6KB1 Antibodies) proteins could be used as novel independent poor prognostic biomarkers for patients with astrocytomas.
MNK-1 controls chemokine (show CCL1 Antibodies) secretion and proliferation in human airway smooth muscle cells.
MNK1 encodes a Ser/Thr protein kinase that interacts with extracellular signal-regulated kinase 1 (show MAPK3 Antibodies) and p38 mitogen-activated protein kinase (show MAPK14 Antibodies), a pathway that is involved in Blood Pressure regulation through norepinephrine and angiotensin II.
Data show that galeterone (gal (show GAL Antibodies)) and VNPT55 inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression via antagonizing the Mnk1/2-eIF4E (show EIF4E Antibodies) axis.
data suggest a physiological role for MNK1a-Ser (show SIGLEC1 Antibodies)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E (show EIF4E Antibodies) phosphorylation in vitro and in vivo.
Data suggest MNK1/MNK2 (show MKNK2 Antibodies) stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (show EIF4E Antibodies) (via decreased binding to eIF4G (show EIF4G1 Antibodies)).
MNK1 participates in mediating high-fat diet-induced insulin (show INS Antibodies) resistance. Our findings reveal distinct roles for the MNKs in a novel area of disease biology
Mnk1 is a novel pancreatic acinar cell-specific stress response kinase that regulates digestive enzyme abundance and eIF4E (show EIF4E Antibodies) phosphorylation.
Long-term potentiation (LTP (show SCP2 Antibodies)) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF (show BDNF Antibodies)-TrkB (show NTRK2 Antibodies) signaling and from TrkB (show NTRK2 Antibodies) to MAP-kinase (show MAPK1 Antibodies)-interacting kinase.
Data suggest that Mnk1 and Mnk2 (show MKNK2 Antibodies) regulate cell migration/wound healing, expression of vimentin (show VIM Antibodies), stability of vimentin (show VIM Antibodies) protein, and binding of eIF4E (eukaryotic translation initiation factor 4E (show EIF4E Antibodies)) and Cyfip1 (cytoplasmic FMR1 interacting protein 1 (show CYFIP1 Antibodies)).
Mnk1/2 has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 (show HAND1 Antibodies) and Th17 differentiation in vivo.
oncogenic role for Mnk1/2 in tumor development
Mnk1 phosphorylation by caspase (show CASP3 Antibodies)-activated Pak2/gamma-PAK (show PAK2 Antibodies) inhibits phosphorylation and interaction of eIF4G (show EIF4G1 Antibodies) with Mnk (show ATP7A Antibodies)
Mnk2 (show MKNK2 Antibodies) and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E (show EIF4EBP2 Antibodies) but not for cell growth or development
Mnk (show ATP7A Antibodies) activation by oxidative stress leading to enhanced eIF4E (show EIF4E Antibodies) phosphorylation may play a role in promoting stress-induced hyperproliferative diseases, such as smooth muscle cell proliferation and hypertrophy in cardiovascular disease.
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.
MAP kinase signal-integrating kinase 1
, MAP kinase-interacting serine/threonine-protein kinase 1
, MAPK signal-integrating kinase 1
, MAP kinase interacting serine/threonine kinase 1
, MAP kinase-interacting kinase 1