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Elevated levels of p-Mnk1, p-eIF4E (show EIF4E Proteins) and p-p70S6K (show RPS6KB1 Proteins) proteins are associated with tumor recurrence and poor prognosis in astrocytomas. Overexpression of p-eIF4E (show EIF4E Proteins) and co-expression of p-Mnk1, p-eIF4E (show EIF4E Proteins) and p-p70S6K (show RPS6KB1 Proteins) proteins could be used as novel independent poor prognostic biomarkers for patients with astrocytomas.
MNK-1 controls chemokine (show CCL1 Proteins) secretion and proliferation in human airway smooth muscle cells.
MNK1 encodes a Ser/Thr protein kinase that interacts with extracellular signal-regulated kinase 1 (show MAPK3 Proteins) and p38 mitogen-activated protein kinase (show MAPK14 Proteins), a pathway that is involved in Blood Pressure regulation through norepinephrine and angiotensin II.
Data show that galeterone (gal (show GAL Proteins)) and VNPT55 inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression via antagonizing the Mnk1/2-eIF4E (show EIF4E Proteins) axis.
data suggest a physiological role for MNK1a-Ser (show SIGLEC1 Proteins)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E (show EIF4E Proteins) phosphorylation in vitro and in vivo.
Data suggest MNK1/MNK2 (show MKNK2 Proteins) stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (show EIF4E Proteins) (via decreased binding to eIF4G (show EIF4G1 Proteins)).
Simultaneous targeting of androgen receptor (show AR Proteins) and MNK1 by novel retinamides inhibits growth of human prostate cancer cell lines.
MNK1 and MNK2 (show MKNK2 Proteins) inhibition ablates eIF4E1 (show EIF4E Proteins) phosphorylation and concurrently enhances eIF4E3 (show EIF4E3 Proteins) expression in diffuse large B-cell lymphoma.
Data show that interferon-gamma (show IFNG Proteins) regulated the metabolism and mRNA translation of macrophages by targeting the kinases mTORC1 and MNK1/2, both of which converge on the selective regulator of translation initiation eukaryotic initiation factor-4E (eIF4E (show EIF4E Proteins)).
Data suggest that a combined pharmacologic inhibition of mTORC1 and Mnk1/2 kinases offers a therapeutic opportunity in blast crisis-chronic myeloid leukemia (BC-CML).
Betacellulin (show BTC Proteins) promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1 (show MAPK3 Proteins)/Erk2 (show MAPK1 Proteins).
North American ginseng inhibits myocardial NOX2 (show CYBB Proteins)-ERK1/2-TNF-alpha (show TNF Proteins) signaling pathway and improves cardiac function in endotoxemia, suggesting that NA ginseng may have the potential in the prevention of clinical sepsis.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (show GFAP Proteins)-positive astrocytes for normal neurodevelopment.
These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 (show MAPK3 Proteins) or Erk2 (show MAPK1 Proteins) significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (show CD44 Proteins) expression, and increased CD44 (show CD44 Proteins) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (show ICAM1 Proteins) and VCAM-1 (show VCAM1 Proteins) by activating the ERK1/2 pathway, resulting in the expression of ETB (show EDNRB Proteins) receptors and the enhancement of contractile function in vascular smooth muscle.
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (show NFkBP65 Proteins), ERK1 (show MAPK3 Proteins), ERK2 (show MAPK1 Proteins) and STAT1 (show STAT1 Proteins) pathways.
MAPK3 (show MAPK3 Proteins)/1 participates in primordial follicle activation through mTORC1-KITL (show KITLG Proteins) signaling.
At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 pathway.
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.
MAP kinase signal-integrating kinase 1
, MAP kinase-interacting serine/threonine-protein kinase 1
, MAPK signal-integrating kinase 1
, MAP kinase interacting serine/threonine kinase 1
, MAP kinase-interacting kinase 1