Browse our Paxillin Proteins (PXN)

Human Paxillin (PXN) interaction partners

1. Glucosamine affects signaling pathway activation of NK-92 immune cells, changing the phosphorylation of FOXO1, paxillin, and the ERK map kinase pathway

2. Data suggest that FGFR3 with mutation found in patients with SADDAN (but not FGFR3 with mutation found in patients with TDII) affects cytoskeleton organization in chondrocytes by inducing tyrosine hyperphosphorylation of paxillin. (FGFR3 = fibroblast growth factor receptor 3; SADDAN = Severe Achondroplasia with Developmental Delay and Acanthosis Nigricans; TDII = Thanatophoric Dysplasia type II)

3. overexpression of Paxillin significantly decreased tumor volume of colorectal cancer; miR-24 was overexpressed in natural killer cells and inhibited paxillin expression.

4. XIST positively regulated PXN levels by sponging miR-137 in vitro and in vivo. Collectively, our study provided the evidence for the cross-talk between XIST, miR-137, and PXN, shedding light on the therapy for non-small cell lung cancer .

5. we herein demonstrated that frequent overexpression of PXN in cervical cancer was associated with advanced tumor stage, poor differentiation and metastasis, and poor predictive outcomes

6. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.

7. we collected paraffin specimens from 85 GBM patients and evaluated the expression pattern of paxillin. Notably, we found that discernable paxillin signals were detected in 67 out of 85 samples. Given that leading edge is critical for cancer cell migration, we propose that NA treatment may be developed into a potential therapy for malignant glioma

8. Pxn binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8(+) T-cell migratory behavior and effector functions.

9. FAK-Src-Paxillin system is a marker of unfavorable prognosis for human Neuroblastoma patients but also a promising therapeutic target.

10. Studies suggest that signaling pathways downstream of activated FAK including paxillin will be important to study in the context of FAK inhibition and other therapeutics to identify novel biomarkers.

11. REVIEW of the functions of paxillin in pathological conditions, particularly in cell migration

12. This study showed that the PXN plays as an oncogene in glioma progression and suggests a new potential biotarget for therapy

13. Recruitment of Paxillin, Cdc42 and N-WASP is necessary for cell adhesion, migration and invasion induced by Estradiol in breast cancer cells.

14. the administration of 10(-6) M retinoic acid (10-20 min) induces the activation of the migration-related proteins Moesin, FAK, and Paxillin in T-47D breast cancer cells.

15. The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing paxillin expression through the alternative splicing of lncRNA-PXN-AS1.

16. These data suggest that paxillin appears to influence major cell functions in a diverse range of prostate and breast cancer models. The responsiveness of cells to environmental factors such as HGF or BME may be influenced by paxillin status, although this seems to be dependent on cell type

17. Knocking out FAK (also known as PTK2) and vinculin caused an increase in nuclear paxillin. This could be reversed by rescue with wild-type FAK but not by FAK with a mutated FAT domain, which inhibits paxillin binding.

18. The role of paxillin in the aging process of skin cells is reviewed.

19. interactions between Cat-1 and its binding partner paxillin are necessary to ensure sufficient Akt activation so that cancer cells are able to grow under anchorage-independent conditions

20. FAK/SRC and paxillin play a role in the pathophysiological aspects of mobile tongue squamous cell carcinoma and could constitute therapeutic targets

Mouse (Murine) Paxillin (PXN) interaction partners

1. the focal adhesion component paxillin is a cytoplasmic substrate of Ccnd1.Cdk4.

2. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.

3. Kindlin-2 is a key protein that couples cell adhesion by activating integrins and the induction of membrane protrusions by activating Rac1 and supplying Rac1 with the Arp2/3 complex.

4. paxillin and FAK function cell-autonomously to control migrating neuron morphology and speed during cortical development.

5. paxillin interacts with processed LC3 through a conserved LIR motif in the amino-terminal end of paxillin and that this interaction is regulated by oncogenic SRC activity.

6. Data show that actomyosin cytoskeletal contractility is required for paxillin localization to developing somite boundaries.

7. paxillin and Hic-5 have both redundant and distinctive functions in invadosome formation.

8. Fyn mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin phosphorylation

9. Lithium therapy abrogated GSK3beta overactivity, blunted paxillin hyperphosphorylation, and reinstated actin cytoskeleton integrity in glomeruli associated with an early attenuation of podocyte foot process effacement.

10. Suggest paxillin up-regulation and phosphorylation as an important mechanism of vascular remodelling underlying pulmonary hypertension.

11. LPS-induced paxillin phosphorylation at Y31 and Y118 was mediated by c-Abl tyrosine kinase

12. Study provides evidence that phosphorylation of PXN is required for cisplatin resistance in lung cancer cells.

13. MELK promotes cell migration and invasion via the FAK/Paxillin pathway, and plays an important role in the occurrence and development of gastric cancer.

14. FAK-paxillin interactions are indispensable for cell adhesion, migration and invasion processes.

15. paxillin and zyxin are LIM-domain adaptor proteins that are recruited to stress fiber strain sites

16. Data indicate that CD45 functions to regulate Pyk2/FAK activity, likely through the activity of Src family kinases, which in turn regulates the levels of paxillin to modulate macrophage adhesion and migration.

17. SLK phosphorylates the adhesion adapter protein paxillin on serine 250. Serine 250 phosphorylation is required for paxillin redistribution and cell motility.

18. Paxillin is critical for integrating physical cues from the ECM with chemical motility signals by spatially constraining where cells form motile processes, and thereby regulates directional migration.

19. Paxillin is a new regulator protein of pulmonary arterial smooth muscle cell growth.

20. The paxillin is the substrate of JNK in Schwann cell migration but JNK targets other than paxillin may be involved in the signaling pathways.

Fruit Fly (Drosophila melanogaster) Paxillin (PXN) interaction partners

1. Data indicate that tramtrack69 regulates ovary epithelial tube morphogenesis through Paxillin, Dynamin, and the homeobox protein Mirror.

2. New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone

3. Results identify a link between the focal adhesion protein paxillin and the Atg1 kinase, which has been previously implicated in autophagy.

4. Data show that Pax genes are involved in the development of the anterior/posterior brain boundary zone during embryonic CNS development in Drosophila.

Xenopus laevis Paxillin (PXN) interaction partners

1. Paxillin has a role in meiosis and may be a general modulator of mitogen-activated protein kinase signaling

2. RING finger protein XRNF185, which physically binds to paxillin and the proteasome. XRNF185 destabilizes paxillin at focal adhesions and promotes mesodermal cell migration during convergent extension.

Zebrafish Paxillin (PXN) interaction partners

1. paxillin may function in adhesion during the morphogenesis of the early zebrafish embryo

Pig (Porcine) Paxillin (PXN) interaction partners

1. Role of Y118 paxillin phosphorylation and stimulated actin polymerization in carotid artery contraction.