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Human Paxillin Protein expressed in HEK-293 Cells - ABIN2728328
Wilson, Bradley, Shaw, Wagenmakers: Paxillin and focal adhesion kinase colocalise in human skeletal muscle and its associated microvasculature. in Histochemistry and cell biology 2014
Show all 2 Pubmed References
Human Paxillin Protein expressed in Wheat germ - ABIN1316962
Wang, Wang, Downey, Plotnikov, McCulloch: A ternary complex comprising FAK, PTPα and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts. in The Biochemical journal 2016
Pxn binding to the CD103 (show ITGAE Proteins) cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8 (show CD8A Proteins)(+) T-cell migratory behavior and effector functions.
FAK (show PTK2 Proteins)-Src (show SRC Proteins)-Paxillin system is a marker of unfavorable prognosis for human Neuroblastoma (show ARHGEF16 Proteins) patients but also a promising therapeutic target.
Studies suggest that signaling pathways downstream of activated FAK (show PTK2 Proteins) including paxillin will be important to study in the context of FAK (show PTK2 Proteins) inhibition and other therapeutics to identify novel biomarkers.
REVIEW of the functions of paxillin in pathological conditions, particularly in cell migration
This study showed that the PXN plays as an oncogene (show RAB1A Proteins) in glioma progression and suggests a new potential biotarget for therapy
Recruitment of Paxillin, Cdc42 and N-WASP is necessary for cell adhesion, migration and invasion induced by Estradiol in breast cancer cells.
the administration of 10(-6) M retinoic acid (10-20 min) induces the activation of the migration-related proteins Moesin (show MSN Proteins), FAK (show PTK2 Proteins), and Paxillin in T-47D breast cancer cells.
The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing paxillin expression through the alternative splicing of lncRNA-PXN-AS1.
These data suggest that paxillin appears to influence major cell functions in a diverse range of prostate and breast cancer models. The responsiveness of cells to environmental factors such as HGF (show HGF Proteins) or BME may be influenced by paxillin status, although this seems to be dependent on cell type
Knocking out FAK (show PTK2 Proteins) (also known as PTK2 (show PTK2 Proteins)) and vinculin (show VCL Proteins) caused an increase in nuclear paxillin. This could be reversed by rescue with wild-type FAK (show PTK2 Proteins) but not by FAK (show PTK2 Proteins) with a mutated FAT domain, which inhibits paxillin binding.
Kindlin-2 (show FERMT2 Proteins) is a key protein that couples cell adhesion by activating integrins and the induction of membrane protrusions by activating Rac1 and supplying Rac1 with the Arp2 (show AICDA Proteins)/3 complex.
paxillin and FAK (show PTK2 Proteins) function cell-autonomously to control migrating neuron morphology and speed during cortical development.
paxillin interacts with processed LC3 (show MAP1LC3A Proteins) through a conserved LIR (show CD300C Proteins) motif in the amino-terminal end of paxillin and that this interaction is regulated by oncogenic SRC (show SRC Proteins) activity.
Data show that actomyosin cytoskeletal contractility is required for paxillin localization to developing somite boundaries.
paxillin and Hic-5 (show TGFB1I1 Proteins) have both redundant and distinctive functions in invadosome formation.
Fyn (show FYN Proteins) mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin phosphorylation
Lithium therapy abrogated GSK3beta overactivity, blunted paxillin hyperphosphorylation, and reinstated actin cytoskeleton integrity in glomeruli associated with an early attenuation of podocyte foot process effacement.
Suggest paxillin up-regulation and phosphorylation as an important mechanism of vascular remodelling underlying pulmonary hypertension.
LPS-induced paxillin phosphorylation at Y31 and Y118 was mediated by c-Abl tyrosine kinase
Study provides evidence that phosphorylation of PXN is required for cisplatin resistance in lung cancer cells.
Data indicate that tramtrack69 regulates ovary epithelial tube morphogenesis through Paxillin, Dynamin (show DNM1 Proteins), and the homeobox protein (show HOXA1 Proteins) Mirror.
New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone
Results identify a link between the focal adhesion protein paxillin and the Atg1 (show ULK1 Proteins) kinase, which has been previously implicated in autophagy.
Data show that Pax genes are involved in the development of the anterior/posterior brain boundary zone during embryonic CNS development in Drosophila.
Paxillin has a role in meiosis and may be a general modulator of mitogen-activated protein kinase (show MAPK1 Proteins) signaling
RING finger protein (show TRIM31 Proteins) XRNF185 (show RNF185 Proteins), which physically binds to paxillin and the proteasome. XRNF185 (show RNF185 Proteins) destabilizes paxillin at focal adhesions and promotes mesodermal cell migration during convergent extension.
paxillin may function in adhesion during the morphogenesis of the early zebrafish embryo
Role of Y118 paxillin phosphorylation and stimulated actin polymerization in carotid artery contraction.
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445).
, Paxillin-derived LIM-only protein
, myocardial ischemic preconditioning associated protein 7