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Results showed that RGS1 expression was significantly higher in melanoma than that noted in nevus tissue and correlated with reduced diseasespecific survival. Also, RGS1 expression was also found to be related to the proliferation and migration of melanoma cells through regulation of Galphasmediated inactivation of AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins).
The rs12022418 in RGS1 showed novel associations in IgA nephropathy.
High RGS1 immunohistochemistry expression associates with poor overall survival in diffuse large B cell lymphoma
RGS1 expression may be a prognostic marker for risk stratification and a promising target for the development of a new multiple myeloma therapy.
Regulator of G-protein signaling 1 rs2816316 was negatively associated with celiac disease .
RGS1 as a potential marker of CRC (show CALR Proteins) tissue quality
RGS1 suppresses CXCL12 (show CXCL12 Proteins)-mediated migration and AKT (show AKT1 Proteins) activation in cultured human plasmacytoma cells and plasmablasts.
Rgs1 has a role in leukocyte trafficking and vascular inflammation
RGS1 and TNFRSF1A (show TNFRSF1A Proteins) polymorphisms tended to be associated with reduced attack severity in Multiple sclerosis.
RGS1 is largely upregulated, whereas RGS2 (show RGS2 Proteins) is downregulated in the majority of solid tumors, whereas RGS5 (show RGS5 Proteins) transcripts are greatly increased in eight subtypes of lymphoma with no reports of downregulation in hematological malignancies
Erk1/2 signalling and calcium influx are major effectors of Rgs1-mediated vascular contractile responses.
Rgs1 knockdown increased the size of germinal centers, but decreased the frequency of T follicular helper cells.
Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs.
RGS1 can modulate the expression of costimulatory molecules and cytokine secretion, and interrupt Toll (show TLR4 Proteins) like receptor signal pathways, which suggest that RGS1 may play a role in regulating immune responses.
Rgs1(-/-) mice possess B cells that respond excessively and desensitize improperly to the chemokines CXCL12 (show CXCL12 Proteins) and CXCL13 (show CXCL13 Proteins). Many of the B-cell follicles in the spleens of Rgs1(-/-) mice have germinal centers even in the absence of immune stimulation.
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
B-cell activation protein BL34
, early response protein 1R20
, immediate-early response 1, B-cell specific
, regulator of G-protein signalling 1
, regulator of G-protein signaling 1
, Regulator of G-protein signaling 1-like protein