Browse our anti-CYP11A1 (CYP11A1) Antibodies

Mouse (Murine) Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) interaction partners

1. melatonin not only elevated progesterone (P) secretion, but also upregulated expressions of StAR and Cyp11a1 and also had an increased Ihh (show IHH Antibodies) expression in endometrium.

2. The results demonstrated that ZnT7 (show SLC30A7 Antibodies) gene silencing downregulated the expression of StAR, P450scc and 3beta-HSD (show HAL Antibodies) as well as progesterone concentrations in the human chorionic gonadotrophin-stimulated Leydig tumor cells.

3. 1,25D3 modulates CD8 (show CD8A Antibodies)+ T cell phenotype via recruitment of the VDR (show CYP27B1 Antibodies) transcription factor to the promoter region of Cyp11a1 leading to prevention of lung allergic responses.

4. Data from Cyp11a1 transgenic mice suggest that overexpression of Cyp11a1 results in reduced pregnancy rate, impaired implantation/placentation, decreased litter size, and stillbirth; overexpression of Cyp11a1 disrupts development of corpus luteum.

5. Cyp11a1 plays an important role in the development of peanut allergy, regulating peanut-induced allergic responses through effects on steroidogenesis, an essential pathway in T(H)2 differentiation.

6. Cyp11a1 controls the phenotypic conversion of CD8 (show CD8A Antibodies)(+) T cells from IFN-gamma (show IFNG Antibodies) to IL-13 (show IL13 Antibodies) production, linking steroidogenesis in CD8 (show CD8A Antibodies)(+) T cells, a nonclassical steroidogenic tissue, to a proallergic differentiation pathway

7. Sodium fluoride inhibited expression of StAR and P450scc in mouse Leydig tumor cells, which inhibited progesterone secretion.

8. LH/hCG (show CGA Antibodies) tightly regulates MKP-2 (show DUSP4 Antibodies) expression, which modulates the induction of CYP11A1 by 8Br-cAMP.

9. Cyp11a1 null embryos had adrenal medulla with abnormal mitochondria. Cells did not synthesized no epinephrine. Decreased diencephalon Hsd11b1 (show HSD11B1 Antibodies), increased Crh (show CRH Antibodies), and increased pituitary Pomc (show POMC Antibodies) expression, thus higher plasma ACTH (show POMC Antibodies)

10. Data suggest that the 5' flanking region of CYP11A gene contains sequences between 2.5 and 5 kb that are necessary for expression of mouse CYP11A in Leydig cells but not in adrenal cells. [REVIEW]

Cow (Bovine) Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) interaction partners

1. We constructed cDNA including genes of the bovine cholesterol hydroxylase/lyase (CHL (show CHRDL1 Antibodies)) system proteins-cytochrome P450scc (CYP11A1), adrenodoxin (Adx (show FDX1 Antibodies)) and adrenodoxin reductase (AdR (show FDXR Antibodies)), that are fused into a single ORF using FMDV 2A nucleotide sequences.

2. Data indicate a role of cytochrome P450 11A1 (CYP11A1 in sterol metabolism.

3. Bovine CYP11A1 manifests 2beta- and 16beta-hydroxylase activity.

4. Data suggest that the upstream region of gene encoding CYP11A contains unique cAMP-responsive sequence and appears to bind unique nuclear proteins or transcription factors in adrenal cortex.

5. Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 (show POR Antibodies) CYP27A1 (show CYP27A1 Antibodies) and CYP11A1.

6. Kinetic and optical biosensor study of adrenodoxin mutant AdxS112W displaying an enhanced interaction towards the cholesterol side chain cleavage enzyme (CYP11A1).

7. Focimatrix may potentially regulate CYP11A1 expression, and the regulation of both could be important in ovarian follicular dominance.

8. Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.

9. Data show that a deletion of 20 amino acids comprising parts of the F-G loop results in an enzyme with a three-fold increased solubility, the highest solubility of a CYP11A1 variant obtained so far.

10. kinetic analysis of CYP11A1

Pig (Porcine) Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) interaction partners

1. We have shown, for the first time to our knowledge, the expression of CYP11A1 gene in the porcine endometrium and myometrium during early pregnancy and the oestrous cycle.

2. Leptin (show LEP Antibodies) in elevated doses, by stimulatory effect on CYP11A1 and 17b-HSD (show HAL Antibodies) protein expression resulting in elevated P(4) and testosterone secretions could be an independent risk factor for cyst formation in both prepubertal and cycling pigs.

3. Tissues expressing P450scc can metabolize 7-dehydrocholesterol to biologically active 7-dehydropregnenolone.

4. Data suggest that gonadotropin-induced accumulation of P450scc mRNA results from increased transcription, and that this stimulation, at least in part, is protein synthesis-dependent.

5. Testicular expression of CYP11A1 is not solely responsible for the QTL influencing boar fat androstenone levels.

6. Under hypoxia reoxygenation or ischemia and reperfusion, StAR and CYP11A1 protein and gene expression was reduced without apparent relation to TSPO changes.