Browse our Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Proteins (CYP19A1)

Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

1. this study illustrated that the brain-specific (show CALY Proteins) alternate promoter PI.f derived CYP19 expression can be regulated by DNA methylation (show HELLS Proteins).

2. sex steroid hormones and sex hormone binding globulin (show SHBG Proteins) levels, CYP17 (show CYP17A1 Proteins) MSP (show MSMB Proteins) AI (-34T:C) and CYP19 codon 39 (Trp:Arg) variants in children with developmental stuttering

3. RET (show RET Proteins) inhibitors could both impair primary tumor growth and tumor dissemination, thereby providing a potential therapeutic advantage when used in combination with aromatase inhibitors in postmenopausal ER+ breast cancers.

4. We suggest from these studies that overexpression of aromatase in breast tissue and its resultant increase in estradiol levels may contribute to the later development of breast cancer in women with atypical ductal hyperplasia

5. As regards the CYP19A1 variant, genotype 11 (del/del) was more frequent in patients than in controls (OR=1.85; 95% CI 1.06-3.22; P=0.03).

6. C-Jun (show JUN Proteins) and CREB (show CREB1 Proteins) are recruited to ESR2 (show ESR2 Proteins) or CYP19A1 promoter by IGF-I (show IGF1 Proteins) stimulation.

7. The results of the present study suggest that AhR (show AHR Proteins) stimulates estrogen-dependent progression of breast carcinoma by inducing aromatase expression under some conditions. These results provide new insights on the possible roles of environmental toxins in breast cancer development.

8. In the postmortem study, the amount of PVN aromatase immunoreactivity decreased significantly in the major depressive disorder group compared to the controls

9. Results show that aromatase protein expression is increased in bladder neoplasm tissue and may be associated with advanced tumor stage.

10. Polymorphism of CYP19 is associated with breast cancer.

Xenopus laevis Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

1. We found that cyp19a1 expression is highly regionalized in the brains of both sexes.

2. Cyp19a1 expression leads to female sex determination in Xenopus laevis.

3. brain-specific (show CALY Proteins) promoter/exon I.f of the cyp19a1 has cis (show CISH Proteins)-elements for several transcriptional factors

4. binding sequences to a specific trans-activating factor upstream of the p450 (show POR Proteins) aromatase promoter II

5. The ontogenetic patterns of Aro, Srd5a1 (show SRD5A1 Proteins) and Srd5a2 (show SRD5A2 Proteins) suggest that these genes are involved in sexual differentiation of gonads and brain already in early developmental stages.

Horse (Equine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

1. co-localization of estrogen receotirs with aromatase in horse trophoblast suggests auto- or intracrine functions of oestrogens in this cell type

Pig (Porcine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

1. CYP19A1 is involved in sperm fertility and its expression in sperm plays an important role in fertilization.

2. P450arom was expressed in all layers of the arterial and venous vessels of the spermatic cord with higher intensity of staining in June long daylight) compared to December(short daylight).

3. Decreased estradiol production via suppression of aromatase may be one of the mechanisms by which miR (show MYLIP Proteins)-378 regulates the maturation of cumulus-oocyte complexes.

4. show that micro-RNA378 (miR (show MYLIP Proteins)-378) is spatiotemporally expressed in porcine granulosa cells, the cells that generate estradiol in the ovary during follicular development, in an inverse manner compared with the expression of aromatase

5. Pig ejaculated spermatozoa express aromatase.

6. The presence of aromatase and 11beta-HSD 2 (show HSD11B2 Proteins) in Leydig cells increased, together with germ and Sertoli cell numbers.

7. This study demonstrates that transferrin (show Tf Proteins) had a dose-dependent inhibitory effect on follicle stimulating hormone-stimulated aromatase activity.

Mouse (Murine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

1. Increased adipose tissue aromatase activity reduces adipose tissue inflammation and improves insulin (show INS Proteins) sensitivity in male mice.

2. Aromatase-knockout (ArKO) mice cannot synthesize estrogens in vivo. Male ArKO mice developed hepatic steatosis accompanied by high testosterone levels.

3. results show that the Aha1 (show AHSA1 Proteins)-Hsp90 (show HSP90 Proteins)-PKM2/HIF-1alpha (show HIF1A Proteins) axis mediates the induction of aromatase in Li-Fraumeni Syndrome (show TP53 Proteins).

4. aromatase could modulate pituitary LH-positive cells in males through local estradiol synthesis.

5. Findings indicate that sex chromosome factors determine sex differences in aromatase expression in the stria terminalis and in the anterior amygdaloid area of mouse embryos.

6. CELF1 (show CELF1 Proteins) downregulates Cyp19a1 (Aromatase) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.

7. Aromatase plays an important role in the survival of metastatic ERalpha (show ESR1 Proteins) breast cancer cells by suppressing anoikis.

8. aromatase may play a key role in the pathogenesis of Sjogren syndrome-like lesions by controlling the target organ and adipose tissue-associated macrophage; increased MPC1 (show BRP44L Proteins) protein expression has a role in adiposity

9. The protective effect of female gender on abdominal aortic aneurysms is due to estrogen synthesis and requires the presence of both ovarian and extragonadal/peripheral aromatase.

10. Aromatase signaling is common in the mouse brain; locally synthesized brain estrogens could mediate biological effects by activating pre- and post-synaptic estrogen alpha and beta receptors, and androgen receptors.

Cow (Bovine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

1. in granulosa cells of dominant follicles the concentration of CYP19P1 mRNA was very low compared to CYP19A1 mRNA. CONCLUSIONS: CYP19P1 and CYP19A1 transcripts might interfere in placental cotyledons

2. These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2 (show FOXL2 Proteins), which does not appear to be the case in the human and rat.

3. This study evaluated the relationships among aromatase, IGF-1 (show IGF1 Proteins), IGF2R (show IGF2R Proteins), and FSH (show BRD2 Proteins) levels expressed in ovarian follicles of cattle selected for twin pregnancies.

4. Data indicated de novo DNA methylation (show HELLS Proteins) fter the luteinizing hormone-induced down-regulation of CYP19A1 expression, suggesting that DNA methylation (show HELLS Proteins) might play a role for permanent silencing of previously down-regulated genes.

5. P450(AROM) is localized in the cytoplasm and only seldom present in the fine extensions of the cells in frontal cortex.

6. Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1 (show HSD3B1 Proteins), and CYP17A1 (show CYP17A1 Proteins) transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.

7. DNA methylation (show HELLS Proteins) may have a role in the permanent shutdown of promoter 2-directed cytochrome P450 19A1(CYP19A1) expression in large (granulosa derived) lutein cells

8. fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary

9. granulosa cell clustering is accompanied by marked increases in FSHr (show FSHR Proteins), IGF-1r (show IGF1R Proteins), and p450 arom expression, and precedes induction and subsequent peak E2 production

10. demonstrates that cattle and sheep use different promoters to direct aromatase(Cyp19) expression during pregnancy

Goat Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

1. These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2 (show FOXL2 Proteins), which does not appear to be the case in the human and rat.

2. Relative mRNA expression for insulin (show INS Proteins) and FSH (show BRD2 Proteins) receptors and cytochrome P450 aromatase in cultured follicles.

Zebrafish Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

1. Dual functions of the cyp19a1a gene during sex differentiation: cyp19a1a is not only indispensable for female sex differentiation but also required for male sex differentiation.

2. The whole-body androgen levels, follicle-stimulating hormone beta (show FSHB Proteins) and luteinizing hormone beta (show LHB Proteins) protein levels in the pituitary, and transcript levels of genes known to be involved in spermatogenesis and steroidogenesis in the testes were significantly higher in the cyp19a1a mutant and aromatase double-mutant males than in the wild-type and cyp19a1b mutant male.

3. The results from the present study strongly suggest that DNA methylation is one of mechanisms that is involved in the regulation of cyp19a1a gene expression during folliculogenesis

4. Data show that cytochrome P450 enzymes Cyp17 (show CYP17A1 Proteins)-I, Cyp11c1 (show CYP11B2 Proteins), Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein (show FOXO4 Proteins) Foxl2a were detected both in the testis and ovary.

5. Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).

6. The differential expression of the aromatase genes, particularly CYP19A2 in the brain, suggests that the two aromatase genes play different roles in the reproductive behavior and/or physiology of bony fish.

7. zebrafish Anti-Mullerian hormone (Amh (show AMH Proteins)) is regulated by sox9a, sox9b, and cyp19a1a during gonad development

8. These results demonstrate seasonal and sex differences in brain aromatase mRNA expression in a teleost fish and suggest a role for aromatase in the expression of vocal-acoustic and alternative male reproductive phenotypes.

9. These analyses suggest that variants of CYP19 are not associated with risk of breast cancer.

10. amh is a candidate gene down-regulating cyp19a1a, leading to "juvenile ovary-to-testis" transformation.