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CYP19A1 is involved in sperm fertility and its expression in sperm plays an important role in fertilization.
P450arom was expressed in all layers of the arterial and venous vessels of the spermatic cord with higher intensity of staining in June long daylight) compared to December(short daylight).
Decreased estradiol production via suppression of aromatase may be one of the mechanisms by which miR (show MYLIP Proteins)-378 regulates the maturation of cumulus-oocyte complexes.
show that micro-RNA378 (miR (show MYLIP Proteins)-378) is spatiotemporally expressed in porcine granulosa cells, the cells that generate estradiol in the ovary during follicular development, in an inverse manner compared with the expression of aromatase
Pig ejaculated spermatozoa express aromatase.
The presence of aromatase and 11beta-HSD 2 (show HSD11B2 Proteins) in Leydig cells increased, together with germ and Sertoli cell numbers.
This study demonstrates that transferrin (show Tf Proteins) had a dose-dependent inhibitory effect on follicle stimulating hormone-stimulated aromatase activity.
C-Jun (show JUN Proteins) and CREB (show CREB1 Proteins) are recruited to ESR2 (show ESR2 Proteins) or CYP19A1 promoter by IGF-I (show IGF1 Proteins) stimulation.
The results of the present study suggest that AhR (show AHR Proteins) stimulates estrogen-dependent progression of breast carcinoma by inducing aromatase expression under some conditions. These results provide new insights on the possible roles of environmental toxins in breast cancer development.
In the postmortem study, the amount of PVN aromatase immunoreactivity decreased significantly in the major depressive disorder group compared to the controls
Results show that aromatase protein expression is increased in bladder neoplasm tissue and may be associated with advanced tumor stage.
Polymorphism of CYP19 is associated with breast cancer.
The combination of high carbohydrate intake and the heterozygote (CG) of CYP19A1 rs4441215 showed a higher serum estradiol level in postmenopausal Japanese women.
Leptin (show LEP Proteins) increased aromatase expression in breast cancer cells, which was correlated with COX-2 upregulation.
Immunohistochemical analysis of 221 invasive breast cancer cases indicated that 87.3% (193/221) had at least 5% aromatase positive cells.
CYP19A1 amplification caused increased aromatase activity.
The reduction of DHT obese homozygotic twins could be linked to its increased degradation by AKR1C2 (show AKR1C2 Proteins) and HSD11B1 (show HSD11B1 Proteins), and increased estrogen levels could be linked to increased adiposity-related expression of aromatase in adipose tissue.
in granulosa cells of dominant follicles the concentration of CYP19P1 mRNA was very low compared to CYP19A1 mRNA. CONCLUSIONS: CYP19P1 and CYP19A1 transcripts might interfere in placental cotyledons
These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2 (show FOXL2 Proteins), which does not appear to be the case in the human and rat.
This study evaluated the relationships among aromatase, IGF-1 (show IGF1 Proteins), IGF2R (show IGF2R Proteins), and FSH (show BRD2 Proteins) levels expressed in ovarian follicles of cattle selected for twin pregnancies.
Data indicated de novo DNA methylation (show HELLS Proteins) fter the luteinizing hormone-induced down-regulation of CYP19A1 expression, suggesting that DNA methylation (show HELLS Proteins) might play a role for permanent silencing of previously down-regulated genes.
P450(AROM) is localized in the cytoplasm and only seldom present in the fine extensions of the cells in frontal cortex.
Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1 (show HSD3B1 Proteins), and CYP17A1 (show CYP17A1 Proteins) transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
DNA methylation (show HELLS Proteins) may have a role in the permanent shutdown of promoter 2-directed cytochrome P450 19A1(CYP19A1) expression in large (granulosa derived) lutein cells
fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
granulosa cell clustering is accompanied by marked increases in FSHr (show FSHR Proteins), IGF-1r (show IGF1R Proteins), and p450 arom expression, and precedes induction and subsequent peak E2 production
demonstrates that cattle and sheep use different promoters to direct aromatase(Cyp19) expression during pregnancy
Increased adipose tissue aromatase activity reduces adipose tissue inflammation and improves insulin (show INS Proteins) sensitivity in male mice.
Aromatase-knockout (ArKO) mice cannot synthesize estrogens in vivo. Male ArKO mice developed hepatic steatosis accompanied by high testosterone levels.
results show that the Aha1 (show AHSA1 Proteins)-Hsp90 (show HSP90 Proteins)-PKM2/HIF-1alpha (show HIF1A Proteins) axis mediates the induction of aromatase in Li-Fraumeni Syndrome (show TP53 Proteins).
aromatase could modulate pituitary LH-positive cells in males through local estradiol synthesis.
Findings indicate that sex chromosome factors determine sex differences in aromatase expression in the stria terminalis and in the anterior amygdaloid area of mouse embryos.
CELF1 (show CELF1 Proteins) downregulates Cyp19a1 (Aromatase) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.
Aromatase plays an important role in the survival of metastatic ERalpha (show ESR1 Proteins) breast cancer cells by suppressing anoikis.
aromatase may play a key role in the pathogenesis of Sjogren syndrome-like lesions by controlling the target organ and adipose tissue-associated macrophage; increased MPC1 (show BRP44L Proteins) protein expression has a role in adiposity
The protective effect of female gender on abdominal aortic aneurysms is due to estrogen synthesis and requires the presence of both ovarian and extragonadal/peripheral aromatase.
Aromatase signaling is common in the mouse brain; locally synthesized brain estrogens could mediate biological effects by activating pre- and post-synaptic estrogen alpha and beta receptors, and androgen receptors.
co-localization of estrogen receotirs with aromatase in horse trophoblast suggests auto- or intracrine functions of oestrogens in this cell type
Relative mRNA expression for insulin (show INS Proteins) and FSH (show BRD2 Proteins) receptors and cytochrome P450 aromatase in cultured follicles.
We found that cyp19a1 expression is highly regionalized in the brains of both sexes.
Cyp19a1 expression leads to female sex determination in Xenopus laevis.
brain-specific (show CALY Proteins) promoter/exon I.f of the cyp19a1 has cis (show CISH Proteins)-elements for several transcriptional factors
binding sequences to a specific trans-activating factor upstream of the p450 (show POR Proteins) aromatase promoter II
The ontogenetic patterns of Aro, Srd5a1 (show SRD5A1 Proteins) and Srd5a2 (show SRD5A2 Proteins) suggest that these genes are involved in sexual differentiation of gonads and brain already in early developmental stages.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity\; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
, cytochrome P450 aromatase
, cytochrome P-450AROM
, cytochrome P450 19 type I
, cytochrome P450, family19, subfamily A, polypeptide 1
, estrogen synthase
, aromatase cytochrome P450
, cytochrome P450 19 type III
, cytochrome P450, family 19, subfamily A, polypeptide 3
, type I cytochrome p450 aromatase
, cytochrome P450 19A1
, estrogen synthetase
, cytochrome P450, subfamily XIX (aromatization of androgens)
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, Cytochrome P450, 19, aromatase
, cytochrome P450 family 19 subfamily a
, cytochrome P450, subfamily 19
, cytochrome P450, family XIX (conversion of androgen to estrogen), aromatase
, cytochrome P450, 19, aromatase
, cytochrome P450 17-alpha
, Cytochrome P-450AROM
, Cytochrome P450 19A1
, Estrogen synthase
, p450 aromatase A