Browse our anti-CYP27B1 (CYP27B1) Antibodies

Cow (Bovine) Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) interaction partners

1. Data show that in tissue and secreted cells from the infected mammary glands, 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-OHase; CYP27B1) gene expression was significantly increased compared to expression in tissue and cells from the healthy mammary tissue.

Human Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) interaction partners

1. Transmission disequilibrium of CYP27B1 allele T of rs4646536 is associated with vitamin D deficiency.

2. Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of high-fat diet fed mice.

3. In a Central European Slovak population, the rs703842 variant in CYP27B1 was a protective factor against multiple sclerosis development.

4. Study found no statistically significant associations of HCV infection outcomes with CYP27B1 gene.

5. analysis of the role of CYP27A1, CYP27B1, and CYP24A1 in non-melanoma skin cancer reveals that the expression of CYP27A1 and CYP24A1, but not CYP27B1 is changed in malignant cells

6. Seven novel mutations of CYP27B1 gene were identified in seven Chinese pseudovitamin D-deficiency rickets families.

7. rs10877012 SNP was associated with asthma risk in a Tunisian population.

8. expression in uterine leiomyoma comparable to expression in normal myometrium

9. These results suggested CYP28B1 gene polymorphisms may be independently associated with the efficacy of IFN in HBeAg-positive patients.

10. Expression analysis showed significant CYP27B1 upregulation in epileptic male patients aged between 30 and 40.

11. We showed that the AA genotype of VDR polymorphism is associated with Familial Mediterranean fever in males but not in females

12. We observed associations between VDR, GC, and CYP27B1 variants and maternal 25-hydroxyvitamin D concentration. Our results provide additional support for a possible role of genetic variation in vitamin D metabolism genes on vitamin D status during pregnancy.

13. detected in chondrocytes of healthy-looking knee cartilage in osteoarthritis patients

14. colorectal cancer (CRC) patients had a higher frequence of insufficient vitamin D and a higher concentration of active vitamin D. These concentration were higher between patients with polymorphic genotypes variants of ApaI and BsmI, CYP24A1 and CYP27B1. Polymorphic genotypes cause a lower correlation between the forms of vitamin D.

15. This Mendelian randomization study provides no evidence that circulating 25OHD concentration plays a major role in the development of PD in individuals of European ancestry.

16. in teens with positive recto-vaginal group B streptococcus colonization, placental mRNA expression of CYP27B1 is lower compared to those who tested negative for this infection

17. Dietary habits, lifestyle, and polymorphisms in VDR (ApaI), CYP24A1 (rs6013897, rs158552, rs17217119) and CYP27B1 (rs10877012) were associated with a higher risk of colorectal cancer

18. primary human osteoblasts in the presence of high calcium concentrations increase their CYP27B1 mRNA levels by 1.3-fold

19. The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli.

20. Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1alpha-Hydroxylase Expression in Vascular Smooth Muscle Cells

Mouse (Murine) Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) interaction partners

1. Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of high-fat diet fed mice.

2. Absence of calcitriol does not impair post-lactation bone recovery in Cyp27b1 null mice.

3. AQP-1 was decreased in renal papilla and AQP-4 expressions were increased in proximal tubule by suppressing renin activity or supplement of Vitamin D analogue. After injecting renin into the lateral ventricle of the 1alpha(OH)ase knockout mice, the renin expression level was decreased in the kidney, followed by the decrease of AQP-1 in renal papilla and increase of AQP-4 in proximal tubule

4. Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1alpha-Hydroxylase Expression in Vascular Smooth Muscle Cells

5. These results reveal that differential regulation of Cyp27b1 expression represents a mechanism whereby 1,25(OH)2D3 can fulfill separate functional roles, first in the kidney to control mineral homeostasis and second in extra-renal cells to regulate target genes linked to specific biological responses.

6. The data indicate that abnormal osteoclastogenesis due to the absence of CYP27B1 expression, consistent with the notion that endogenous metabolism of 25-hydroxyvitamin D optimizes osteoclastogenesis and ameliorates the resulting activity of mature osteoclasts.

7. The absence of 25-hydroxyvitamin D3-1alpha-hydroxylase potentiates the suppression of EAE in mice by ultraviolet light.

8. Cyp27b1(-/-) mice exhibited hypocalcemia, growth defects, and skeletogenesis dysfunction, similar to Vdr(-/-) mice, but do not display alopecia

9. Findings demonstrate that in-tumor CYP27B1 1-alpha-hydroxylase activity plays a crucial role in controlling early oncogene-mediated mammary carcinogenesis events, at least in part by modulating tumoral cell NF-kappaB p65 nuclear translocation.

10. the effect of 25-hydroxyvitamin D-1-alpha-hydroxylase on the atherosclerosis disease both in apolipoprotein (apo) E-/- mice and wild-type mice, was investigated.

11. P450C1 alpha deficiency results in abnormal calcium handling and cardiac dysfunction in mice with defective vitamin D signaling.

12. Throughout the male reproductive tract specific bands of CYP27B1 are determined.

13. observed a 3- to 10-fold increase in CYP27B1 mRNA abundance in the lung, spleen, aorta and testis of FGF-23 null/1alpha-Luc mice

14. Data show that the absence of either of the two key hydroxylases, vitamin D 25-hydroxylase (CYP2R1) or vitamin D 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)neither inhibits nor enhances the development of experimental autoimmune encephalomyelitis (EAE).

15. These results confirm the expression of vitamin D receptor and Cyp27b1 in vivo and suggest a potential role for vitamin D(3) in skeletal muscle regeneration following injury.

16. Bone formation parameters were increased significantly in all pups fed by dams on the rescue diet but were still lower in 1alpha(OH)ase(-/-) pups than in 1alpha(OH)ase(+/-) pups.

17. 1alpha-hydroxylase may have a role in enhanced radiosensitivity

18. regulation of bone CYP27B1 is unique from that in the kidney, and may play an important role in bone formation

19. study shows CYP27B1 can hydroxylate 25-hydroxyvitamin D2 & 25-hydroxyvitamin D3 associated with phospholipid membranes; low activity found at higher membrane levels of 25-hydroxyvitamin D; substrate inhibition may contribute to enzyme activity regulation

20. findings demonstrate that regulation of both the 25-hydroxyvitamin D-1 alpha-hydroxylase and 25-hydroxyvitamin D-24-hydroxylase genes by phosphorus is disordered in hypophosphatemic mice at the level of renal mRNA expression