Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

Alternative names and synonyms associated with CYP27B1

• cytochrome P450 family 27 subfamily B member 1 (cyp27b1) antibody
• cytochrome P450 family 27 subfamily B member 1 (CYP27B1) antibody
• cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27B1) antibody
• cytochrome P450, family 27, subfamily b, polypeptide 1 (Cyp27b1) antibody

• Cp2b antibody
• Cyp1 antibody
• CYP1alpha antibody
• Cyp27b antibody
• Cyp40 antibody
• Show all synonym aliases
• P450c1 antibody
• Pddr antibody
• Vdd1 antibody
• Vddr antibody
• VddrI antibody
• Vdr antibody

Protein level used designations for CYP27B1

cytochrome P450, family 27, subfamily B, polypeptide 1 , 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial , mitochondrial 25 hydroxyvitamin D3-1alpha-hydroxylase , 1alpha(OH)ase , 25 hydroxyvitamin D3-1-alpha hydroxylase , 25-OHD-1 alpha-hydroxylase , VD3 1A hydroxylase , calcidiol 1-monooxygenase , cytochrome P450 subfamily XXVIIB polypeptide 1 , cytochrome P450C1 alpha , cytochrome P450VD1-alpha , cytochrome p450 27B1 , 25-hydroxyvitamin D(3) 1-alpha-hydroxylase , P450C1 alpha , P450VD1-alpha , cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase) , cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1 , cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase) , cytochrome P450, subfamily 27b, polypeptide 1 , 25(OH)D 1alpha-hydroxylase , 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha) , 25-hydroxyvitamin D3 1alpha-hydroxylase , P450VD1alpha , cytochrome P450, 27b1