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Human POMC Protein expressed in Wheat germ - ABIN1315730
La Rosa, Uccella, Dainese, Marchet, Placidi, Vigetti, Capella: Characterization of c-kit (CD117) expression in human normal pituitary cells and pituitary adenomas. in Endocrine pathology 2008
We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.
Hypothalamic pro-opiomelanocortin and AgRP (show AGRP Proteins) neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
cloning and characterization of the pro-opiomelanocortin gene
Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.
Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.
Glutamate transporter (show SLC1A1 Proteins)-associated protein 3 (show HSPB3 Proteins)-18 (GTRAP3-18 (show Arl6ip5 Proteins)), an anchor protein (show CELSR3 Proteins) that retains interacting proteins in the endoplasmic reticulum, is a critical regulator of food intake and body weight by interacting with POMC. GTRAP3-18 (show Arl6ip5 Proteins)-deficient mice showed hypophagia, lean bodies, and lower blood glucose, insulin (show INS Proteins), and leptin (show LEP Proteins) levels with increased serum and brain alpha-MSH levels, leading to AMPK (show PRKAA1 Proteins) inhibition.
Immunostaining of serial sections of the hypothalamus revealed that POMC-expressing neurons were smaller in WNK1 (show WNK1 Proteins) TG mice than in WT mice.
Selenoprotein T (show SELT Proteins) is a novel oligosaccharyltransferase subunit that regulates unfolded protein response signaling and ACTH secretion.
Study shows that alpha melanocyte stimulating hormone and forkhead box C2 protein promote fatty acid oxidation through C/EBPbeta (show CEBPB Proteins) negative transcription in mice adipose tissue.
Our findings demonstrate alphaMSH plays a key role in the prevention of adipose inflammation and inflammatory diseases by down-regulating Akt (show AKT1 Proteins)/JNK (show MAPK8 Proteins) signal pathway and negatively interacting with FoxOs, which brings up alphaMSH as a novel candidate factor in the adipose anti-inflammation process in obesity.
Data indicate the regulation of energy balance in BMPR1A (show BMPR1A Proteins)-mediated appetite regulation in POMC neurons.
POMC and AgRP (show AGRP Proteins) neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1 (show KISS1 Proteins)(ARC (show NOL3 Proteins)) neurons in male mice
Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.(
disruption of this hippocampal POMC/MC4R (show MC4R Proteins) circuit might contribute to synaptic dysfunction observed in Alzheimer's disease.
The data show that somatic MORs in POMC neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
Data suggest that the stress of intermittent hypoxia up-regulates expression of mRNA and protein for POMC and CART in neuronal cell lines; GATA2 (show GATA2 Proteins) and GATA3 (show GATA3 Proteins) appear to be involved in these stress mechanisms. (POMC = proopiomelanocortin; CART = cocaine- and amphetamine-regulated transcript protein (show CARTPT Proteins); GATA2 (show GATA2 Proteins) = endothelial transcription factor GATA-2 (show GATA2 Proteins); GATA3 (show GATA3 Proteins) = T-cell-specific transcription factor GATA-3 (show GATA3 Proteins))
Mutation in POMC gene is associated with severe obesity, hypothyroidism, adrenal insufficiency and abnormal reddish hair pigmentation.
In both melanoma cell lines, alphaMSH determined the reduction of proliferation through the PI(4,5)P2/PLC (show HSPG2 Proteins) pathway, employing PPARgamma (show PPARG Proteins) as an effector element. These evidence could offer perspectives for new therapeutic approaches for melanoma.
The human beta-endorphin amyloid was studied in detail, exploiting solid-state NMR spectroscopy and TEM (show CYLD Proteins) analyses.
POMC and MC1R were significantly lower in vitiligo (show MITF Proteins) lesional skin than in non-lesional skin as well as in controls and they were significantly higher in non-lesional skin than in the skin of the controls.
POMC has played an extraordinary role in the development of molecular endo-crinology and has clearly not yet given up all its secrets.
E2F1 (show E2F1 Proteins)-mediated hPOMC transcription is a potential target for suppressing ACTH production in ectopic Cushing's syndrome.
Elevated ACTH secretion is associated with Cushing's syndrome.
a novel p53 (show TP53 Proteins)/POMC/Galphas (show GNAS Proteins)/SASH1 (show SASH1 Proteins) autoregulatory positive feedback loop is regulated by SASH1 (show SASH1 Proteins) mutations to induce pathological hyperpigmentation phenotype.
Data suggest that alpha-MSH enhances cell adhesion to fibronectin (show FN1 Proteins) in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF (show TNF Proteins), IL-6 (show IL6 Proteins) and IL-8 (show IL8 Proteins)) in such synoviocyte cultures.
The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK (show PENK Proteins)) and prodynorphin (PDYN (show PDYN Proteins)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
The association has been reported between polymorphisms of the CRH (show CRH Proteins) and POMC genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC c.288C>T with start-of-finishing weight (SOF (show GJA1 Proteins) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (show PHB2 Proteins); P = 0.03) and marbling
The polymorphism of POMC gene is associated with the growth traits of Nanyang cattle.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
, adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, proopiomelanocortin, beta (endorphin, beta)
, proopoimelanocortin, beta (endorphin, beta)
, beta-melanocyte stimulating hormone
, pro-opiomelanocortin a-1
, pro-opiomelanocortin a-2
, pro-opiomelanocortin b-1
, pro-opiomelanocortin b-2