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Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor (show AR Proteins) and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (show DPT Proteins) mice
observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes
The induction of Srd5a2 through SREBP-2 (show SREBF2 Proteins) provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies.
The study described in this article shows that selected SRD5A1 (show SRD5A1 Proteins) and SRD5A2 polymorphisms can alter the levels of metabolic and hormonal parameters in patients with BPH (show GLI3 Proteins). Special attention should be paid to the SDR5A2 rs12470143 polymorphism, which is associated with a change in lipid profile, as well as with the inheritance and incidence rate of MetS (show ETV3 Proteins) among these patients.
mutations of the SRD5A2 gene are the main causes of posterior hypospadias
Findings suggest that 5alpha-reductases (5-AR) isoenzymes could be explored as a therapeutic target for urothelial bladder cancer (UBC) with 5alpha-reductase inhibitors (5-ARI).
Lack of SRD5A2 expression in the prostate induces an androgenic to oestrogenic switch in human benign prostatic tissues.
deficiency of 5-alpha reductase type 2 was considered and SRD5A2 was sequenced. This identified homozygous pathogenic variants in SRD5A2 (p. Pro212Arg), which confirmed a diagnosis of deficiency of 5-alpha reductase type 2
Chromosomal anomalies and mutations of the SRD5A2 gene are associated with hypospadias.
Polymorphism in the SRD5A2 gene is associated with hypospadias.
In a recent study we reported associations between ALTs and single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptor 1 (ESR1 (show ESR1 Proteins)), steroid-5-alpha-reductase, type 2 (SRD5A2) and sex hormone-binding globulin (SHBG (show SHBG Proteins)). No associations between the previously associated SNPs in the genes ESR1 (show ESR1 Proteins) and SRD5A2 and autistic-like traits could be seen in the large replication sample.
Studies indicate that enhanced 5alpha-reductase activity in subjects with polycystic ovary syndrome (PCOS) was associated with insulin (show INS Proteins) resistance (IR) rather than obesity.
Mutations in the SRD5A2 cause a disorder of 46,XY sex development, termed 5alpha-reductase type 2 deficiency. (Review)
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
3-oxo-5-alpha-steroid 4-dehydrogenase 2
, steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
, steroid-5-alpha-reductase alpha polypeptide 2
, 5 alpha-SR2
, SR type 2
, steroid 5 alpha reductase type2
, steroid 5-alpha-reductase 2
, S5AR 2
, type II 5-alpha reductase
, prostatic steroid 5-alpha-reductase type II