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is an active metalloenzyme, and AGB1 and ARD1 both control embryonic hypocotyl length by modulating cell division; they also may contribute to the production of ethylene, a product of the methionine salvage pathway.
High ADI1 expression is associated with malignant glioma.
The thermal stability of the HsARD isozymes is a function of the metal ion identity, with Ni2+-bound HsARD being the most stable followed by Co2+ and Fe2+, and Mn2+-bound HsARD being the least stable.
In summary, clinical and cell-based experiments suggested that physical interaction between MT1-MMP and ADI1 led to suppression of hepatitis C virus infection. This inhibitory effect could be reversed by ADI1 overexpression.
Data elucidate a new role for MTCBP-1 regulating the intracellular function of MT1-MMP-mediated autophagy. Their inverse expression correlation with brain tumor grades could also contribute to the decreased autophagic index observed in high-grade tumors.
MTCBP-1 is a new member of the Cupin superfamily with a role as an invasion suppressor down-regulated in tumors
nucleo-cytoplasmic transport of hADI1 is regulated by a non-canonical nuclear export signal (NES) located in the N-terminal region of hADI1.
ADI1 may check prostate cancer progression through apoptosis by an activity that does not require metal binding.
293-ADI1-CD81 cells are permissive for serum-derived HCV infection.
This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20.
, aci-reductone dioxygenase
, acireductone dioxygenase (Fe(2+)-requiring)
, acireductone dioxygenase (Ni(2+)-requiring)
, membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1
, acireductone dioxygenase 1
, acireductone dioxygenase 1-like
, MT1-MMP cytoplasmic tail-binding protein-1
, membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1
, submergence induced protein 2
, submergence-induced protein-like factor
, aci-reductone dioxygenase (ARD)-like protein 1
, androgen-responsive ARD-like protein 1
, androgen-responsive gene encoding an ARD-like protein